2,077 research outputs found
Does inhibiting Sur1 complement rtPA in cerebral ischemia?
No full textHemorrhagic transformation (HT) associated with recombinant tissue plasminogen activator (rt-PA) complicates and limits its use in stroke. Here, we provide a focused review on the involvement of matrix metalloproteinase 9 (MMP-9) in rt-PA-associated HT in cerebral ischemia, and we review emerging evidence that the selective inhibitor of the sulfonylurea receptor 1 (Sur1), glibenclamide (U.S. adopted name, glyburide), may provide protection against rt-PA-associated HT in cerebral ischemia. Glyburide inhibits activation of MMP-9, ameliorates edema formation, swelling, and symptomatic hemorrhagic transformation, and improves preclinical outcomes in several clinically relevant models of stroke, both without and with rt-PA treatment. A retrospective clinical study comparing outcomes in diabetic patients with stroke treated with rt-PA showed that those who were previously on and were maintained on a sulfonylurea fared significantly better than those whose diabetes was managed without sulfonylureas. Inhibition of Sur1 with injectable glyburide holds promise for ameliorating rt-PA-associated HT in stroke
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Experimental and statistical reevaluation provides no evidence for Drosophila courtship song rhythms
No full textFrom 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previously performed automated segmentation of songs but failed to detect the proposed rhythm [Arthur BJ, et al. (2013) BMC Biol 11:11; Stern DL (2014) BMC Biol 12:38]. Kyriacou et al. [Kyriacou CP, et al. (2017) Proc Natl Acad Sci USA 114:1970–1975] report that we failed to detect song rhythms because (i) our flies did not sing enough and (ii) our segmenter did not identify many of the song pulses. Kyriacou et al. manually annotated a subset of our recordings and reported that two strains displayed rhythms with genotype-specific periodicity, in agreement with their original reports. We cannot replicate this finding and show that the manually annotated data, the original automatically segmented data, and a new dataset provide no evidence for either the existence of song rhythms or song periodicity differences between genotypes. Furthermore, we have reexamined our methods and analysis and find that our automated segmentation method was not biased to prevent detection of putative song periodicity. We conclude that there is no evidence for the existence of Drosophila courtship song rhythms
Oregon serious crime survey
No full textauthor, survey administration and data processing: Stan WoodwellCaption titleThis archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposesBureau of Justice Statistics, United States Department of Justice 80-BJ-CX-K009 82-BJ-CX-0002 82-BJ-CX-0014Mode of access: Internet from the Oregon Government Publications CollectionText in Englis
BJ-TSA-9, a Novel Human Tumor-Specific Gene, Has Potential as a Biomarker of Lung Cancer
No full textAbstractUsing bioinformatics, we have identified a novel tumorspecific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcriptionpolymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (68.8%). To explore the potential application of BJ-TSA-9 for the detection of circulating cancer cells in lung cancer patients, nested RT-PCR was performed. The overall positive detection rate was 34.3% (24 of 70) in peripheral blood mononuclear cells (PBMCs) of patients with various types of lung cancers and was 53.6% (15 of 28) in PBMCs of lung adenocarcinoma patients. In combination with the detection of two known marker genes SCC and LUNX, the detection rate was increased to 81.4%. A follow-up study was performed in 37 patients after surgical removal of tumor mass. Among nine patients with persistent detection of two to three tumor marker transcripts in PBMCs, six patients had recurrence/metastasis. In contrast, 28 patients with transient detection of one tumor marker or without detection of any tumor marker were all in remission. Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients
Bj: Physical Parts Bj
No full textComments are invited and should be directed to the author at the address listed below. Please do not reproduce in any way without the permission of the authors. A complet
Estimation of the number of periodic orbits
No full textThe main theme of this paper is to estimate, for self-maps f : X --> X of compact polyhedra, the asymptotic Nielsen number N-infinity(f) which is defined to be the growth rate of the sequence {N(f(n))} of the Nielsen numbers of the iterates of f. The asymptotic Nielsen number provides a homotopy invariant lower bound to the topological entropy h(f). To introduce our main tool, the Lefschetz zeta function, we develop the Nielsen theory of periodic orbits. Compared to the existing Nielsen theory of periodic points, it features the mapping torus approach, thus brings deeper geometric insight and simpler algebraic formulation. The important cases of homeomorphisms of surfaces and punctured surfaces are analysed. Examples show that the computation involved is straightforward and feasible. Applications to dynamics, including improvements of several results in the recent literature, demonstrate the usefulness of the asymptotic Nielsen number.MathematicsSCI(E)19ARTICLE1151-18517
Who invented vaccination?
No full textEdward Jenner, whose ‘Inquiry’ (1798)1 was the first published report of vaccination against smallpox, is widely seen as the inventor of vaccination. However, other individuals could lay claim to this title, notably his contemporaries, Benjamin Jesty and John Fewster. Jesty, a Dorset farmer, performed vaccinations in 1774, 22 years before Jenner’s first vaccination in 1796. Fewster, an apothecary-surgeon who knew Jenner personally, is also reported to have performed the procedure several years before Jenner. However, neither Jesty nor Fewster published or publicised their work and both were recognised retrospectively, notably by critics of Jenner. This article compares the contributions of these three putative ‘inventors’ of vaccination.peer-reviewe
Sarcoidosis of the hypothalamus and pituitary stalk
No full textWe report a rare case of sarcoidosis of the hypothalamic and suprasellar region, with clinical course and the magnetic resonance imaging follow-up
Desain Interior Hotel BJ. Perdana Berkonsep Modern dengan Sentuhan Budaya Pasuruan
No full textHotel merupakan salah satu bentuk akomodasi yang dikelola secara komersial, yang disediakan bagi setiap orang untuk memperoleh pelayanan, penginapan berikut makanan dan minuman. Provinsi Jawa Timur, sebagai salah satu wilayah tujuan wisata di Indonesia, menawarkan berbagai macam obyek wisata baik obyek wisata alam, budaya, maupun buatan. Salah satu daerah tujuan wisata di Jawa Timur yang menawarkan keindahan alam yaitu pemandangan alam pegunungan yang salah satunya ada di Kota Pasuruan. Oleh karena itu, diperlukannya sarana akomodasi yang baik secara kualitas dan kuantitas. BJ. Perdana merupakan salah satu hotel terbaik di Kota Pasuruan, letak dari hotel tersebut cukup strategis dan banyak diminati oleh pengunjung. Namun sayang interior hotel tersebut belum tertatat cukup baik, dan tidak menyimbolkan bahwa hotel tersebut berada di kota Pasuruan.
Pada tugas akhir ini penulis meredsain hotel BJ. Perdana berkonsep modern dengan sentuhan budaya Pasuruan. Penulis juga memberikan informasi mengenai budaya yang ada di kota Pasuruan dengan cara di tuangkan dalam desain interiornya. Dengan menerapkan beberapa bentukan hasil budaya serta warna yang menjadi ciri khas kota Pasuruan. Ini bertujuan agar pengunjung tau akan budaya dan ciri khas dari Kota Pasuruan itu sendiri. Dan juga dapat menjadikan media promosi serta ikut andil dalam program pemerintahan Kota Pasuruan.
Dalam mendesain interior restoran diperlukan metode desain. Metode yang digunakan yaitu pengumpulan data, analisa data, konsep dan pengembangan desain, serta desain akhir. Hasil yang diharapkan adalah sebuah desain interior hotel yang menunjang kebudayaan setempat agar dapat melestarikan budaya setempat serta menjadi media promosi kepada para wisatawan yang berkunjung.
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The hotel is a form of commercially managed accommodation, provided for everyone to get service, with food and drinks. East Java Province, as one of the tourist destinations in Indonesia, offers a variety of attractions both natural attractions, culture, and artificial. One of the tourist destinations in East Java that offers natural beauty that is the natural scenery of the mountains one of which is in Pasuruan. Therefore, the need for good accommodation facilities in quality and quantity. BJ. Perdana is one of the best hotels in Pasuruan City, the location of the hotel is quite strategic and much in demand by visitors. But unfortunately the interior of the hotel has not been recorded well enough, and does not symbolize that the hotel is located in the city of Pasuruan. In this final project the author redesigned the hotel BJ. Perdana modern concept with a touch of Pasuruan culture. The author also provides information about the existing culture in the city of Pasuruan by way of pour in interior design. By applying some formation of cultural and color results that characterize the city of Pasuruan. It aims to let visitors know the culture and characteristics of Pasuruan City itself. And also can make the media campaign and take part in government program of Pasuruan City. In designing the interior design method is required. The method used is data collection, data analysis, concept and design development, and final design. The expected result is a hotel interior design that supports the local culture in order to preserve the local culture and become a media campaign to the tourists who visit
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