346 research outputs found
Interview with Eli Rosenbaum
No full textFor transcript, click the Download button above. For video index, click the link below.
Eli M. Rosenbaum (WG\u2777) served as director of the U.S. DOJ Office of Special Investigations, which was primarily responsible for identifying, denaturalizing, and deporting Nazi war criminals, from 1994 to 2010, when the office was merged into the new Human Rights and Special Prosecution Section. He is now the Director of Human Rights Enforcement Strategy and Policy in the new Department of Justice section. He is the primary author of Betrayal: The Untold Story of the Kurt Waldheim Investigation, which narrates the inquiry he led into Waldheim\u27s involvement in Nazi war crimes. In 1997 he was named an honorary fellow of Penn Law School
How the end begins the road to a nuclear World War III
No full textIn this startling new book, bestselling author Ron Rosenbaum gives us a wake-up call about this new age of peril and delivers a provocative analysis of how close - and how often - the world has come to nuclear annihilation and why we are once again on the brink. Rosenbaum tracks down key characters in our new nuclear drama and probes deeply into their war game strategies, fears, and moral agonie
Differential Cooperation of a Carcinogen with Human Papillomavirus Type 6 and 16 DNAs in in vitro Oncogenic Transformation
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Variable Myopathic Presentation in a Single Family with Novel Skeletal RYR1 Mutation
No full textWe describe an autosomal recessive heterogeneous congenital myopathy in a large consanguineous family. The disease is characterized by variable severity, progressive course in 3 of 4 patients, myopathic face without ophthalmoplegia and proximal muscle weakness. Absence of cores was noted in all patients. Genome wide linkage analysis revealed a single locus on chromosome 19q13 with Zmax = 3.86 at theta = 0.0 and homozygosity of the polymorphic markers at this locus in patients. Direct sequencing of the main candidate gene within the candidate region, RYR1, was performed. A novel homozygous A to G nucleotide substitution (p.Y3016C) within exon 60 of the RYR1 gene was found in patients. ARMS PCR was used to screen for the mutation in all available family members and in an additional 150 healthy individuals. This procedure confirmed sequence analysis and did not reveal the A to G mutation (p.Y3016C) in 300 chromosomes from healthy individuals. Functional analysis on EBV immortalized cell lines showed no effect of the mutation on RyR1 pharmacological activation or the content of intracellular Ca(2+) stores. Western blot analysis demonstrated a significant reduction of the RyR1 protein in the patient's muscle concomitant with a reduction of the DHPRalpha1.1 protein. This novel mutation resulting in RyR1 protein decrease causes heterogeneous clinical presentation, including slow progression course and absence of centrally localized cores on muscle biopsy. We suggest that RYR1 related myopathy should be considered in a wide variety of clinical and pathological presentation in childhood myopathies
The early socioeconomic effects of teenage childbearing
No full textA large body of literature has documented a negative correlation between teenage childbearing and teen mothers’ socioeconomic outcomes, yet researchers continue to disagree as to whether the association represents a true causal effect. This article extends the extant literature by employing propensity score matching with a sensitivity analysis using Rosenbaum bounds. The analysis of recent cohort data from the National Longitudinal Study of Adolescent Health shows that (1) teenage childbearing has modest but significant negative effects on early socioeconomic outcomes and (2) unobserved covariates would have to be more powerful than known covariates to nullify the propensity score matching estimates. The author concludes by suggesting that more research should be done to address unobserved heterogeneity and the long-term effects of teenage childbearing for this young cohort.propensity score matching, Rosenbaum Bounds, selection bias, teen childbearing
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?
No full textHereditary inclusion body myopathy (HIBM) is a rare neuromuscular disorder caused by mutations in GNE, the key enzyme in the biosynthetic pathway of sialic acid. While the mechanism leading from GNE mutations to the HIBM phenotype is not yet understood, we searched for proteins potentially interacting with GNE, which could give some insights about novel putative biological functions of GNE in muscle. We used a Surface Plasmon Resonance (SPR)-Biosensor based assay to search for potential GNE interactors in anion exchanged fractions of human skeletal muscle primary culture cell lysate. Analysis of the positive fractions by in vitro binding assay revealed alpha-actinin 1 as a potential interactor of GNE. The direct interaction of the two proteins was assessed in vitro by SPR-Biosensor based kinetics analysis and in a cellular environment by a co-immunoprecipitation assay in GNE overexpressing 293T cells. Furthermore, immunohistochemistry on stretched mouse muscle suggest that both GNE and alpha-actinin 1 localize to an overlapping but not identical region of the myofibrillar apparatus centered on the Z line. The interaction of GNE with alpha-actinin 1 might point to its involvement in alpha-actinin mediated processes. In addition these studies illustrate for the first time the expression of the non-muscle form of alpha-actinin, alpha-actinin 1, in mature skeletal muscle tissue, opening novel avenues for its specific function in the sarcomere. Although no significant difference could be detected in the binding kinetics of alpha-actinin 1 with either wild type or mutant GNE in our SPR biosensor based analysis, further investigation is needed to determine whether and how the interaction of GNE with alpha-actinin 1 in skeletal muscle is relevant to the putative muscle-specific function of alpha-actinin 1, and to the muscle-restricted pathology of HIBM
International crime victim survey 2005: Criminal victimization in Istanbul households
No full textAkdaş Mitrani, Tevhide Aslı (Dogus Author) -- Conference full title: World Conference on Psychology, Counselling and Guidance, WCPCG-2010; Antalya; Turkey; 22 April 2010 through 25 April 2010This study aimed to explore the nature of criminal victimization in Istanbul. Face-to-face interviews were conducted using the standard ICVS questionnaire to a randomly selected sample of 1242 householders. Five-year victimization rates were found to be the highest for burglary and attempted burglary. One-year victimization rates for these two types of criminal victimization were higher than those for other European cities. It was found that rates of reporting the offenses to the police in Istanbul were comparably lower than in other European cities. Fear of crime was found to be comparably higher. The findings from Istanbul were discussed in the light of the international results.This research was funded by TÜBİTAK, Grant no SBB 104K100
Annotated Translation: Ron Rosenbaum, Explaining Hitler. Harper Perennial, 1999, part of chapter 3.
No full textThe aim of this bachelor thesis is to translate a part of the third chapter of the book Explaining Hitler by the American author Ron Rosenbaum. The selected excerpt discusses the German newspaper the Munich Post that was being published until 1933 and focuses on the crucial role its editors played during Hitler's rise to power. The thesis also includes a translation analysis of the source text, a description of the translation method, a typology of translation procedures and shifts as well as an analysis of the translation problems
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