178,236 research outputs found
New Diamond-α Steffensen-Type Inequalities for Convex Functions over General Time Scale Measure Spaces
No full textIn this paper, we extend some Steffensen-type inequalities to time scales by using the diamond-α-dynamic integral. Further, we prove some new Steffensen-type inequalities for convex functions utilizing positive σ-finite measures in time scale calculus. Moreover, as a special case, we obtain these inequalities for the delta and the nabla integral. By using the relation between calculus on time scales T and differential calculus on R, we obtain already-known Steffensen-type inequalities
Basins of Attraction for Various Steffensen-Type Methods
No full textThe dynamical behavior of different Steffensen-type methods is analyzed. We check the chaotic behaviors alongside the convergence radii (understood as the wideness of the basin of attraction) needed by Steffensen-type methods, that is, derivative-free iteration functions, to converge to a root and compare the results using different numerical tests. We will conclude that the convergence radii (and the stability) of Steffensen-type methods are improved by increasing the convergence order. The computer programming package MATHEMATICA provides a powerful but easy environment for all aspects of numerics. This paper puts on show one of the application of this computer algebra system in finding fixed points of iteration functions
LXR-dependent and -independent effects of oxysterols on immunity and tumor growth.
No full textOxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be independent of LXR activation. LXR-dependent oxysterol effects can be ascribed to the activation of LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional activation or trans-repression of target genes. The prevalent activation of one isoform seems to be cell-, tissue-, or context-specific, as shown in some pathologic processes, i.e., infectious diseases, atherosclerosis, and autoimmunity. Oxysterol-LXR signaling has recently been shown to inhibit antitumor immune responses, as well as to modulate tumor cell growth. Here, we review the mechanisms that link oxysterols to tumor growth, and discuss possible networks at the basis of LXR-dependent and -independent oxysterol effects on immune cells and tumor development
Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn's disease
No full textNo abstract available. Erratum in: Gut. 2007 Dec;56(12):1800. Steffensen, R [added] DOI:10.1136/gut.2006.109504corr1 Udgivelsesdato: 2007-FebNo abstract available. Erratum in: Gut. 2007 Dec;56(12):1800. Steffensen, R [added
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
JOM816179_SM – Supplemental material for Putting the “Management” Back in Human Resource Management: A Review and Agenda for Future Research
No full textSupplemental material, JOM816179_SM for Putting the “Management” Back in Human Resource Management: A Review and Agenda for Future Research by David S. Steffensen, B. Parker Ellen, Gang Wang and Gerald R. Ferris in Journal of Management</p
Emerging role of thyroid hormone metabolites
No full textThyroid hormones (THs) are essential for the regulation of development and metabolism in key organs. THs produce biological effects both by directly affecting gene expression through the interaction with nuclear receptors (genomic effects) and by activating protein kinases and/or ion channels (short-term effects). Such activations can be either direct, in the case of ion channels, or mediated by membrane or cytoplasmic receptors. Short-term-activated signalling pathways often play a role in the regulation of genomic effects. Several TH intermediate metabolites, which were previously considered without biological activity, have now been associated with a broad range of actions, mostly attributable to short-term effects. Here, we give an overview of the physiological roles and mechanisms of action of THs, focusing on the emerging position that TH metabolites are acquiring as important regulators of physiology and metabolism
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Two Weeks
No full textTwo Weeks is a 9-part LGBT web series, created by students in the Masters of Screen Production at Griffith Film School. The series was the first major web series at GFS and won a string of awards on the festival circuit, including the inaugural Best Student Web Series at Melbourne Web Fest. It has gained over 2 million views on its YouTube channel.No Full Tex
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