95 research outputs found
Sviluppo di piante bioreattore per la produzione di polipeptidi elastino-simili
No full textCon questo progetto si è inteso valutare le capacità produttive di una specie modello, Oryza sativa, nell'espressione e produzione del polimero elastino-simile HELP (Human Elastin-Like Polypeptide) che ricalca il motivo esapeptidico VAPGVG della tropoelastina umana. Sono state definite le procedure di estrazione di HELP-R da farina di riso e condotti studi di caratterizzazione del polimero prodotto intervenendo sui fattori che ne determinano la transazione di fase: temperatura, forza ionica e p
Archange Tuccaro, ‘un comico virtuoso e studioso’ à la cour d’Henri IV
No full textThe treatise by Archange Tuccaro : Trois dialogues de l9exercice de sauter et de voltiger en l9air
was dedicated to king Henri IV by the author in 1599. The book represents the fruits of the meeting of two
cultures : the French and the Italian ones. By showing the utility of physical education for young aristocrats
as a form of civilité, and by explaining the method of performing leaping and tumbling, the author
contributes to contemporary debates about dignity of dance and he gives legitimacy to actors, dancers and to
their art. The many learned sources corroborate this aim which places Tuccaro among the defenders of
virtuous work of actors during the age of Counter-Reformation
"Figure e intersezioni: tra danza e letteratura. Con un saggio di J. Lotman inedito in Italia", Quarto quaderno del Dottorato in Letterature Straniere e Scienze della Letteratura, Università di Verona, a cura di Laura Colombo e Stefano Genetti, Verona, Edizioni Fiorini, 2010,
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Napoleone Martinuzzi per la chiesa di Santa Maria di Lourdes a Mestre
No full textReading the impressive plaster sculptural group of Martinuzzi (1963, signed) inside the Santa Maria of
Lourdes Church, at Mestre – an unicum in the artistic production of our sculptor – the author finds stylistic
references to the long course of the venetian plastic art, from Byzantine influences to that 15th century ones,
and more recent formal consonances to the main avant-garde movements of the 1900 first decades
The distinct role of the flexible polymer matrix in catalytic conversions over immobilised nanoparticles
No full textPolymer resins with immobilized metal nanoparticles represent highly promising materials for attaining intelligent and ecologically friendly catalysts. Control of the dynamic swelling behaviour of the polymer resins enables the on/off-switching of the activity of the encapsulated metal nanoparticles, thereby allowing conversion and selectivity to be controlled at a specific time of the chemical reaction. This paper presents a study on the distinct role of the polymer support. Here, the hydrogenation of nitrobenzene was chosen as a model reaction, and nanoparticles of different metals were taken into account. The course of the reaction revealed the essential role of the polymer resins in controlling the diffusion, in particular of the reagents, to and from the catalytically active sites on the surface of the nanoparticles thereby influencing the catalytic activity of the metal and opening up a new approach to catalytic engineering
Electrochemical impedance spectroscopy and fluorescence lifetime imaging of lipid mixtures self-assembled on mercury
No full textAccelerating the transition batch to continuous in pharmaceutically relevant hydrogenation processes
No full textDie Entwicklung von kontinuierlichen Prozessen in den feinchemischen und pharmazeutischen Industrien ist kritisch um schnellere, selektivere, sicherere und automatisierte Prozesse zu gewährleisten. Diese Doktorarbeit behandelt die Anwendung verschiedener Konzepte, wie z.b. die Implementierung von Prozessanalytik, verschiedenen Reaktortechnologien, kinetische Studien und Prozessentwicklungsmethoden. Kapitel 3 konzentriert sich auf die Entwicklung einer 7-schritt Methode zur Entschützung eines komplexen und teuren Oligopeptids. Es wurde gezeigt dass die Entschützung dieses komplexen Moleküls in einem Festbettreaktor mithilfe eines einfachen Modellmoleküls in Anwesenheit von verschiedenen Additiven simuliert werden konnte. Die entwichelte Methode konnte den Verbrauch des eigentlichen Zielmoleküls minimieren und so auch das Risiko von fehlgeschlagenen Versuchen reduzieren. So konnte mit dieser Methode ein kontinuierlichen Prozess zur Entschützung des Oligopeptids mit einer Ausbeute und Reinheit von >95% über einen Zeitraum >6 h entwickelt werden. Kapitel 4 behandelt die Hydrierung von CBD, ∆8-THC und ∆9-THC über verschiedenen metallbeschichteten, katalytischen Mischelementen. Die Ergebnisse zeigten dass Pd/Al2O3, galvanisiertes Pd und Ru/Al2O3 in dieser Reaktion wenig aktiv und unselektiv sind, über Zeit desaktivieren und große Mengen an Nebenprodukten bilden. Bei Verwendung von Pt/Al2O3 konnten hohe Aktivität und Konversation an Verbindungen beobachtet werden. Bei Temperaturen 80 °C konnte lineare Desaktivierung beobachtet werden. Wir führten diese Desaktivierung auf eine Mischung verschiedener Effekte zurück: Probleme mit internem Massentransfer und einer verringerten, effektiven Katalysatoroberfläche. Die Gesamtkinetik der Hydrierung von CBD, sowie die Katalysatordesaktivierung wurden in einem kontinuierlichen Experiment im dynamischen Gleichgewicht untersucht. Kapitel 5 demonstriert die Verwendung dynamischer Durchflussexperimente mit Echtzeitanalytik um den Fortschritt und die Selektivität der komplexen Hydrierung von 4-Hydroxyacetphenon zu modelieren.Die Konzentrationen der Rektanten wurden hierbei mit einem chemometrischen Modell bestimmt. Drei verschiedene Katalysatoren (Pd/Al2O3, Pt/Al2O3 und Ru/Al2O3) zeigten verschiedene Selektivitäten. Batch-angenäherte und Pfropfenströmungsmodelle wurden verwended um die Reaktionskinetik zu studieren, welche eine Quantifizierung des Reaktionsfortschritts ermöglichten. Dieses quantitative Modell wurde dann verwendet um die verschiedenen Selektivitäten zu erklären, sowie weitere in silico Reaktionsoptimierung und Tests zu durchzuführen. Diese Doktorarbeit zeigt dass oftmals eine einzelene Methode nicht fähig ist alle Komplexitäten in der Prozessentwicklung zu addressieren, die Kombination mehrerer Methoden und Technologien ist kritisch um das Problem auf die bestmögliche Art zu lösen.The transition from batch to continuous manufacturing is crucial to deliver faster, more selective, safer and automated processes in the fine chemical and pharmaceutical industry. Among the different approaches that can be used to help this transition, this thesis focuses on the implementation of process analytics, reactor technologies, kinetic studies and the development of protocols. Hydrogenation processes have been selected for their industrial relevance. Chapter 3 focuses on the development of a 7-step workflow for the deprotection of a complex and expensive oligopeptide. It was shown that the deprotection of this complex molecule in a packed bed reactor could be mimicked by using a simpler surrogate compound in the presence of additives. The derived workflow was able to minimize the consumption of the real compound, thus minimizing the perceived risk of failure. For the given compound, the workflow could deliver a process able to continuously deprotect the oligopeptide for >6 h, with a yield and a purity of >95%. Chapter 4 studies the hydrogenation of CBD, ∆8-THC and ∆9-THC over different metal-coated catalytic static mixers. Pd/alumina, Pd-electroplated and Ru/alumina catalytic static mixers (CSMs) displayed low activity, poor selectivity with the formation of impurities, or rapid catalyst deactivation. Pt/alumina CSMs displayed instead high activity in the conversion of all the compounds and we managed to obtain excellent yields of H2CBD (90%), H4CBD (95%) and HHC (98%) at temperatures lower than 80 °C, a pressure of 20 Barg and with short contact times (<544 s). At temperatures above 80 °C we observed linear deactivation of the CSMs, that we linked to a combination of internal mass transfer limitation and a decrease in the available catalyst surface for the accumulation of both starting material and products. The lump kinetics of the hydrogenation of CBD was finally studied in continuous and at steady state, also including the deactivation of the CSMs. Chapter 5 displays the use of dynamic flow experiments with real-time analytics to rapidly model the progress and selectivity of the complex hydrogenation of 4¬hydroxy acetophenone, whose concentrations were followed with process analytics and partial least squares models. Three different CSMs, Pd/alumina, Pt/alumina and Ru/alumina, displayed different activity and selectivity. Batch-approximated and plug flow models were used to study the kinetics, which was able to provide a quantitative approximation of the reaction progress, explaining the different selectivity and help with a further in silico reaction optimization and testing. This thesis highlights that often a single methodology is not capable of capturing all the aspects of process development, but many tools are available to address the challenges in the best possible way.Stefano Martinuzzi, Dott.Mag.Dott.Enthält LiteraturangabenKumulative Dissertation aus vier ArtikelnDissertation Universität Graz 2025Zusammenfassungen in deutscher, italienischer und englischer SpracheArchivierung/Langzeitarchivierung gewährleistet AT-OeNB pdage
La guirlande de Laura: écritures des femmes et écritures des arts de la Renaissance à l'extrême contemporain. Mélanges offerts à Laura Maria Colombo par ses collègues et amis
No full textIn occasione del pensionamento della Professoressa Laura Maria Colombo, i colleghi e gli amici hanno deciso di comporre per lei questa guirlande di saggi, pensieri e immagini dedicati, per lo più, alle tematiche della sua ricca e intensa attività scientifica: scrittura delle donne, arte, musica e danza, ma anche i colori dell'ailleurs francofono a lei molto caro e al centro delle sue ricerche e della sua appassionata attività didattica. I contributi qui raccolti spaziano dunque dalla letteratura teatrale e narrativa del Cinquecento all'extrême contemporain, senza tralasciare le francofonie e gli studi di carattere linguistico, dai dizionari sulla danza ai dizionari bilingui.
Il volume è stato curato da Rosanna Gorris Camos e da Luca Elfo Jaccond, in collaborazione con Stefano Genetti, Maria Francesca Bonadonna, Paola Perazzolo e Paola Martinuzzi che hanno generosamente collaborato alla rilettura e all'editing dei saggi. Stefano Genetti ha inoltre riunito la Bibliografia di Laura Colombo. Il Prof. Daniele Speziari si è invece occupato dell’edizione digitale dei saggi, con la collaborazione tecnica di Valeria Averoldi e di Luca Elfo Jaccond.
Gli autori: Monica Barsi, Riccardo Benedettini, Anna Bettoni, Maria Francesca Bonadonna, Cristina Brancaglion, Giampaolo Caliari, Lisanna Calvi, Magda Campanini, Gabriela Cultrera, Silvia D’Amico, Béatrice Didier, Paolo Frassi, Stefano Genetti, Maria Teresa Giaveri, Rosanna Gorris Camos, Peter Kofler, Pierluigi Ligas, Anderson Magalhães, Paola Martinuzzi, Tommaso Meldolesi, Alain Montandon, Silvia Monti, Paola Perazzolo, Matteo Pessot, Franco Piva, Alessandra Preda, Massimo Scotti, Giovanni Tallarico, Corrado Viola
Reduction in respiratory exacerbation rate in patients with severe bilateral cerebral palsy following daily PEP-mask therapy: a retrospective study
No full textRespiratory complications caused by the inability to protect the upper airways and ineffective cough represent a major cause of morbidity and mortality in patients with cerebral palsy (CP). Even though the application of Positive End-Expiratory Pressure (PEP) through a face mask has gained large popularity as a technique to prevent bronchial mucous encumbrance, its long term effects on clinical course and respiratory function in individuals with CP have not been investigated
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