1,721,042 research outputs found
capitolo 35 Leucemie
No full textSiamo giunti alla terza edizione del nostro testo italiano originale di oncologia.
La medicina in generale non è statica e ogni testo subisce velocemente il logorio legato al tempo che trascorre.
L’oncologia è una delle discipline veterinarie a più rapido sviluppo e, per soddisfare una clientela sempre più incline a intraprendere un percorso diagnostico e terapeutico delle malattie tumorali, è necessario che il medico veterinario abbia un’adeguata preparazione per poter consigliare al meglio i proprietari.
Pertanto, pur conservando gli obbiettivi originari, questa terza edizione è stata profondamente rinnovata per soddisfare le diverse esigenze dei lettori, dando maggior spazio agli aspetti interdisciplinari propri dell’oncologia, tra cui la chirurgia, e affrontando in modo rinnovato le metodiche e le terapie attualmente disponibili, per gestire al meglio il paziente oncologico.
L’opera illustra i princìpi generali che guidano le indagini diagnostiche e le modalità di trattamento delle malattie tumorali, fornendo approfondimenti per le neoplasie dei singoli apparati e offrendo una rilevante parte iconografica e schemi decisionali chiari e semplici.
L’oncologia è indubbiamente una materia complessa, dove la vita e la morte si intrecciano. Quest’opera non ha la pretesa di trovare soluzione a tutti i quesiti, ma ha l’ambizione di accendere una luce e di suggerire un approccio in un campo della medicina veterinaria che, da sempre, è un po’ oscuro.
Curatori e autori sono una squadra di professionisti che, con grande competenza e capacità comunicativa, hanno saputo cogliere lo spirito interdisciplinare dell’opera, trasferendo nozioni e novità in campo medico-veterinario, rendendo questo testo una guida rivolta non solo al neofita, ma anche a chi ha esperienza specifica, e fornendo al medico veterinario tutti gli strumenti necessari per affrontare il paziente oncologico con un approccio sistematico
Prognostic evaluation of flow cytometry on post-chemotherapy lymph nodes in dogs with large B-cell lymphoma in complete clinical remission and its impact on time to relapse.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Minimal Residual Disease assessment based on IgH rearrangements and flow cytometry in canine Diffuse Large B-cell Lymphoma
No full textIntroduction
Canine diffuse large B-cell lymphoma (cDLBCL) accounts for 30-40% of lymphoma cases. The persistence of cells unidentifiable through cytology is termed Minimal Residual Disease (MRD). Currently, MRD is measured by flow-cytometry (FC). The aim of the study was to determine the diagnostic and prognostic role of rearranged IgH (PARR analysis) in the lymph node (LN), peripheral blood (PB) and bone marrow (BM) in cDLBCL compared with FC.
Materials and methods
PB, BM aspirate and LN tissue from 17 DLBCL were available for PARR analysis at diagnosis (T0) and at the end of treatment (T1). The concordance between PARR and FC was analyzed for LN, PB and BM.
Results
At T0, the B-cell origin of the lymphomas was confirmed by IgH Major rearrangements in the LN of all dogs. Eleven dogs (64.7%) showed simultaneous IgH rearrangements in BM and PB, whereas 6 dogs (35.3%) had no rearrangements in none of the samples. At T1, IgH monoclonal rearrangement was found in 13 (81%), 8 (50%) and 6 dogs (38%) in LN, PB and BM, respectively.
At T0, the concordance rate between FC and PARR was 100%, 82% and 47% for LN, PB and BM, respectively. The highest concordance rate was obtained in LNs (PARR-positive/FC-positive), whereas the highest discordance was obtained in BM (PARR-positive/FC-negative).
At T1, the concordance rate was overall reduced, accounting for 47%, 50%, and 63% in LN, PB and BM, respectively. The highest discordance rate was found in LNs (PARR-positive/FC-negative), whereas the highest concordance was found in BM (PARR-negative/FC-negative).
Discussion
We propose the use of both, PARR and FC, in tandem to offset the possibility of false-negative MRD assessment; in case of discrepant results, dogs should be closely monitored to detect a possible early recurrence. The concordance rate was largely dependent on the time point, being higher in T0. The discordance between PARR and FC results in dogs in clinical remission may be due to the limited number of available cells, which reduces the sensitivity of FC
The dog as a possible animal model for human non-Hodgkin lymphoma: a review
No full textLymphoma represents the most frequent hematopoietic cancer in dogs, and it shows significant overlap with the human disease. Several environmental factors have been associated with canine lymphoma, suggesting that they may contribute to lymphomagenesis. Canine lymphoma often presents in advanced stage (III-V) at diagnosis and, most commonly, has an aggressive clinical course requiring prompt treatment, which relies on the use of polychemotherapy. In this review, we will summarize the state-of-the-art of canine lymphoma epidemiology, pathobiology, diagnostic work-up and therapy, and will highlight the links to the corresponding human disease, providing evidence for the use of dog as an animal model of spontaneous disease
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