1,720,961 research outputs found
Melanoma thickness and skin thickness ratio as the prognostic factor of sentinel lymph node metastasis
No full textSentinel limfni čvor najvažniji je prognostički pokazatelj melanoma koji je pozitivan u 20% bolesnika. Postoje brojni prognostički pokazatelji metastaza u sentinel limfnome čvoru, ali ne uzimaju u obzir odnos debljine kože i debljine melanoma.
U 120 bolesnika s melanomom kože od 2005. do 2009. godine uz standardne prognostičke pokazatelje melanoma određivana je i debljina kože, te omjer debljine melanoma i debljine kože. Analiziran je utjecaj prognostičkih pokazatelja na metastaze u sentinel limfnome čvoru.
U bolesnika (M-59, Ž-61) srednje dobi 55,9 godina, najčešće lokalizacije melanoma su na trupu (50,8%), prosječne debljine melanoma 3,11 mm. Ulceracija je prisutna u 40 (33,3%), regresija tumora u 2 (1,7%), vaskularna invazija u 7 (5,8%), limfocitna infiltracija tumora u 14 (11,7%), više od 1 mitoze/mm2 u 3 (2,5%) bolesnika. U 97 (80,8%) bolesnika bila je samo jedna regija u kojoj se nalazio sentinel limfni čvor, dok je u preostalih 23 (19,2%) bolesnika bilo dvije ili više drenažnih limfnih regija. U prosjeku je odstranjen 1,61 limfni čvor po bolesniku. U 27 (22,5%) bolesnika metastaze su bile prisutne u sentinel limfnom čvoru, a u 11 (9,2%) bolesnika izolirane tumorske stanice. Na prisutnost metastaze u sentinel limfnome čvoru univarijatnom analizom statistički su bile značajne debljina melanoma (p=0,00001), omjer debljine melanoma i debljine kože (p=0,00022) te ulceracija (p=0,007). U multivarijatnoj analizi niti jedan parametar nije bio statistički značajan. Analizom omjera specifičnosti i senzitivnosti debljina melanoma je veće specifičnosti i senzitivnosti (0,781) nego omjer debljine melanoma i debljine kože (0,723).
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Zaključno, univarijatnom analizom omjer debljine melanoma i debljine kože statistički je značajan prognostički pokazatelj prisutnosti metastaze u sentinel limfnome čvoru. Debljina melanoma je najznačajniji pokazatelj metastaza u sentinel limfnome čvoru, a i ulceracija je statistički značajan pokazatelj, iako s manjom statističkom značajnošću nego prethodna dva.Sentinel lymph node is the most significant prognostic factor in melanoma, that harbors metastasis in 20% of cases. There is no prognostic factor that takes into consideration skin thickness and melanoma thickness.
In 120 patients treated for melanoma from 2005 to 2009, along with standard melanoma prognostic factors, skin thickness was measured and ratio of melanoma thickness and skin thickness was calculated. Influence of melanoma prognostic factors were analyzed on sentinel lymph node positivity.
120 patients (59-M, 61-F) average age 55,9 years had most of melanomas localized on trunk (50,8%). Average melanoma thickness was 3,11 mm, ulceration was present in 40 (33,3%), regression in 2 (1,7%), vascular invasion in 7 (5,8%), tumor infiltrating lymphocytes in 14 (11,7%), more than 1 mitosis/mm2 in 3 (2,5%) patients. In 97 patients (80,8%) there was single, while in 23 patients (19,2%) 2 or more draining lymph basains contained sentinel lymph node. 1,61 sentinel lymph node was removed per patient. In 27 (22,5%) patients sentinel lymph node harbored metastasis, in 11 (9,2%) patients isolated tumor cells were found. Melanoma thickness was most significant predictor of metastasis in sentinel lymph node (p=0,00001), followed by melanoma thickness and skin thickness ratio (p=0,00022) and ulceration (p=0,007) in univariate analysis. In multivariate analysis no prognostic factor was significant. ROC analysis showed more specificity and sensitivity for
97
melanoma thickness (0,781) than for melanoma thickness and skin thickness ratio (0,723).
Melanoma thickness and skin thickness ratio is significant prognostic factor in melanoma, although melanoma thickness is the most significant prognostic factor in melanoma, ulceration is important prognostic factor but not so significant as former two
Melanoma thickness and skin thickness ratio as the prognostic factor of sentinel lymph node metastasis
No full textSentinel limfni čvor najvažniji je prognostički pokazatelj melanoma koji je pozitivan u 20% bolesnika. Postoje brojni prognostički pokazatelji metastaza u sentinel limfnome čvoru, ali ne uzimaju u obzir odnos debljine kože i debljine melanoma.
U 120 bolesnika s melanomom kože od 2005. do 2009. godine uz standardne prognostičke pokazatelje melanoma određivana je i debljina kože, te omjer debljine melanoma i debljine kože. Analiziran je utjecaj prognostičkih pokazatelja na metastaze u sentinel limfnome čvoru.
U bolesnika (M-59, Ž-61) srednje dobi 55,9 godina, najčešće lokalizacije melanoma su na trupu (50,8%), prosječne debljine melanoma 3,11 mm. Ulceracija je prisutna u 40 (33,3%), regresija tumora u 2 (1,7%), vaskularna invazija u 7 (5,8%), limfocitna infiltracija tumora u 14 (11,7%), više od 1 mitoze/mm2 u 3 (2,5%) bolesnika. U 97 (80,8%) bolesnika bila je samo jedna regija u kojoj se nalazio sentinel limfni čvor, dok je u preostalih 23 (19,2%) bolesnika bilo dvije ili više drenažnih limfnih regija. U prosjeku je odstranjen 1,61 limfni čvor po bolesniku. U 27 (22,5%) bolesnika metastaze su bile prisutne u sentinel limfnom čvoru, a u 11 (9,2%) bolesnika izolirane tumorske stanice. Na prisutnost metastaze u sentinel limfnome čvoru univarijatnom analizom statistički su bile značajne debljina melanoma (p=0,00001), omjer debljine melanoma i debljine kože (p=0,00022) te ulceracija (p=0,007). U multivarijatnoj analizi niti jedan parametar nije bio statistički značajan. Analizom omjera specifičnosti i senzitivnosti debljina melanoma je veće specifičnosti i senzitivnosti (0,781) nego omjer debljine melanoma i debljine kože (0,723).
95
Zaključno, univarijatnom analizom omjer debljine melanoma i debljine kože statistički je značajan prognostički pokazatelj prisutnosti metastaze u sentinel limfnome čvoru. Debljina melanoma je najznačajniji pokazatelj metastaza u sentinel limfnome čvoru, a i ulceracija je statistički značajan pokazatelj, iako s manjom statističkom značajnošću nego prethodna dva.Sentinel lymph node is the most significant prognostic factor in melanoma, that harbors metastasis in 20% of cases. There is no prognostic factor that takes into consideration skin thickness and melanoma thickness.
In 120 patients treated for melanoma from 2005 to 2009, along with standard melanoma prognostic factors, skin thickness was measured and ratio of melanoma thickness and skin thickness was calculated. Influence of melanoma prognostic factors were analyzed on sentinel lymph node positivity.
120 patients (59-M, 61-F) average age 55,9 years had most of melanomas localized on trunk (50,8%). Average melanoma thickness was 3,11 mm, ulceration was present in 40 (33,3%), regression in 2 (1,7%), vascular invasion in 7 (5,8%), tumor infiltrating lymphocytes in 14 (11,7%), more than 1 mitosis/mm2 in 3 (2,5%) patients. In 97 patients (80,8%) there was single, while in 23 patients (19,2%) 2 or more draining lymph basains contained sentinel lymph node. 1,61 sentinel lymph node was removed per patient. In 27 (22,5%) patients sentinel lymph node harbored metastasis, in 11 (9,2%) patients isolated tumor cells were found. Melanoma thickness was most significant predictor of metastasis in sentinel lymph node (p=0,00001), followed by melanoma thickness and skin thickness ratio (p=0,00022) and ulceration (p=0,007) in univariate analysis. In multivariate analysis no prognostic factor was significant. ROC analysis showed more specificity and sensitivity for
97
melanoma thickness (0,781) than for melanoma thickness and skin thickness ratio (0,723).
Melanoma thickness and skin thickness ratio is significant prognostic factor in melanoma, although melanoma thickness is the most significant prognostic factor in melanoma, ulceration is important prognostic factor but not so significant as former two
Melanoma thickness and skin thickness ratio as the prognostic factor of sentinel lymph node metastasis
No full textSentinel limfni čvor najvažniji je prognostički pokazatelj melanoma koji je pozitivan u 20% bolesnika. Postoje brojni prognostički pokazatelji metastaza u sentinel limfnome čvoru, ali ne uzimaju u obzir odnos debljine kože i debljine melanoma.
U 120 bolesnika s melanomom kože od 2005. do 2009. godine uz standardne prognostičke pokazatelje melanoma određivana je i debljina kože, te omjer debljine melanoma i debljine kože. Analiziran je utjecaj prognostičkih pokazatelja na metastaze u sentinel limfnome čvoru.
U bolesnika (M-59, Ž-61) srednje dobi 55,9 godina, najčešće lokalizacije melanoma su na trupu (50,8%), prosječne debljine melanoma 3,11 mm. Ulceracija je prisutna u 40 (33,3%), regresija tumora u 2 (1,7%), vaskularna invazija u 7 (5,8%), limfocitna infiltracija tumora u 14 (11,7%), više od 1 mitoze/mm2 u 3 (2,5%) bolesnika. U 97 (80,8%) bolesnika bila je samo jedna regija u kojoj se nalazio sentinel limfni čvor, dok je u preostalih 23 (19,2%) bolesnika bilo dvije ili više drenažnih limfnih regija. U prosjeku je odstranjen 1,61 limfni čvor po bolesniku. U 27 (22,5%) bolesnika metastaze su bile prisutne u sentinel limfnom čvoru, a u 11 (9,2%) bolesnika izolirane tumorske stanice. Na prisutnost metastaze u sentinel limfnome čvoru univarijatnom analizom statistički su bile značajne debljina melanoma (p=0,00001), omjer debljine melanoma i debljine kože (p=0,00022) te ulceracija (p=0,007). U multivarijatnoj analizi niti jedan parametar nije bio statistički značajan. Analizom omjera specifičnosti i senzitivnosti debljina melanoma je veće specifičnosti i senzitivnosti (0,781) nego omjer debljine melanoma i debljine kože (0,723).
95
Zaključno, univarijatnom analizom omjer debljine melanoma i debljine kože statistički je značajan prognostički pokazatelj prisutnosti metastaze u sentinel limfnome čvoru. Debljina melanoma je najznačajniji pokazatelj metastaza u sentinel limfnome čvoru, a i ulceracija je statistički značajan pokazatelj, iako s manjom statističkom značajnošću nego prethodna dva.Sentinel lymph node is the most significant prognostic factor in melanoma, that harbors metastasis in 20% of cases. There is no prognostic factor that takes into consideration skin thickness and melanoma thickness.
In 120 patients treated for melanoma from 2005 to 2009, along with standard melanoma prognostic factors, skin thickness was measured and ratio of melanoma thickness and skin thickness was calculated. Influence of melanoma prognostic factors were analyzed on sentinel lymph node positivity.
120 patients (59-M, 61-F) average age 55,9 years had most of melanomas localized on trunk (50,8%). Average melanoma thickness was 3,11 mm, ulceration was present in 40 (33,3%), regression in 2 (1,7%), vascular invasion in 7 (5,8%), tumor infiltrating lymphocytes in 14 (11,7%), more than 1 mitosis/mm2 in 3 (2,5%) patients. In 97 patients (80,8%) there was single, while in 23 patients (19,2%) 2 or more draining lymph basains contained sentinel lymph node. 1,61 sentinel lymph node was removed per patient. In 27 (22,5%) patients sentinel lymph node harbored metastasis, in 11 (9,2%) patients isolated tumor cells were found. Melanoma thickness was most significant predictor of metastasis in sentinel lymph node (p=0,00001), followed by melanoma thickness and skin thickness ratio (p=0,00022) and ulceration (p=0,007) in univariate analysis. In multivariate analysis no prognostic factor was significant. ROC analysis showed more specificity and sensitivity for
97
melanoma thickness (0,781) than for melanoma thickness and skin thickness ratio (0,723).
Melanoma thickness and skin thickness ratio is significant prognostic factor in melanoma, although melanoma thickness is the most significant prognostic factor in melanoma, ulceration is important prognostic factor but not so significant as former two
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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