511 research outputs found
Cicinnus magnapuncta Kaye 1901
No full text<i>Cicinnus magnapuncta</i> (Kaye, 1901) <p>(Figs. 6, 9, 10, 31)</p> <p> <b>Type locality.</b> Trinidad, Tabaquite [NHMUK, syntype examined, designated here as lectotype] <i>Perophora magnapuncta</i> Kaye, 1901: Kaye (1901); Kaye & Lamont (1927).</p> <p> <i>Cicinnus magnapuncta</i> was described and illustrated implicitly from one (but possibly more) specimens collected at Tabaquite, central Trinidad, in June 1898 by W.J. Kaye (Kaye 1901, Kaye & Lamont 1927). Kaye (1901) does not indicate the sex of the type material but his illustration and the single specimen recognized as a type in the NHMUK is female (Fig. 31). The syntype in the NHMUK lacks a collecting data label, though it does bear a label reading “Trinidad, Kaye” and the accession number 1901-72. On the reverse of the accession label, <i>Perophora magnapuncta</i> Kaye is handwritten, in a style similar to that seen for other Kaye types from 1901 in NHMUK, although different from Kaye’s characteristic writing on later types. A red edged type label is also present on the specimen, along with a genitalia preparation label (the genitalia are apparently missing because the slide only contains the terminal two abdominal segments). We therefore believe that this specimen is a syntype, and here designate it as the lectotype with the following labels: C, magnapuncta Keyes [<i>recte</i> Kaye] Type genit.pr. No 6 Mimallonidae / BMNH(E) #805414/ NHMUK010588329/ Type [red edged circular label]/ Trinidad Kaye 1901 -72 [number after 1901 unclear, 72 or 92, written on upper surface of label]; <i>Perophora magnapuncta</i> Kaye [written on lower surface of label]/ LECTOTYPE ♀ <i>Perophora magnapuncta</i> Kaye designated by St Laurent and Cock, 2017 [red handwritten label].</p> <p> <i>Cicinnus magnapuncta</i> was the only mimallonid species described from Trinidad until <i>C. trini</i> described above. Although <i>C. magnapuncta</i> seemed to be endemic to the island, a single male specimen from French Guiana in the MNHN (Fig. 9) may be this species considering the similarities in external appearance to the females and the close affinity of Trinidad Mimallonidae with those of French Guiana. However, due to the lack of males from Trinidad, it is not possible to definitively state at this time that the two populations are conspecific. Interestingly, so far only females of <i>C. magnapuncta</i> have been collected or photographed in Trinidad, thus males seem to either not be strongly attracted to light or are potentially diurnal or crepuscular whereas the females arrive late (23.51 h and 0 0.44 h) at light (K. Sookdeo pers. comm.).</p> <p> Several similar <i>Cicinnus</i> species are known from mainland South America, namely: <i>C. bactriana</i> (Butler, 1878), <i>C. callipius</i> Schaus, 1928, <i>C. candacus</i> Schaus, 1928, <i>C. gaujoni</i> (Dognin, 1922), and <i>C. marona</i> Schaus, 1905. Primary types of all species have been examined by the first author. <i>Cicinnus magnapuncta</i> is unique in having weak maculation, particularly submarginally, such that there is a complete absence of dark petiolate scales. The relatively faint postmedial lines and discal spots, as well as light brown to fawn ground coloration, also can be used to distinguish <i>C. magnapuncta</i> from other species listed previously, which are darker brown or nearly orange in the case of <i>C. marona</i>, and nearly always have stronger maculation.</p> <p> Prior to this work, <i>C. magnapuncta</i> was only known from a single location in Trinidad, therefore we report several new locations for this species, and figure actual specimens (not a painted illustration) for the first time. This species is restricted to forested areas of Trinidad, though the previously mentioned specimen from French Guiana may be this species. In addition to the lectotype collected from Tabaquite in the Central Range, <i>C. magnapuncta</i> has been found on the slopes of the Northern Range.</p> <p> <b>Material examined.</b> (1 ♂ *, 6 ♀ total) <b>TRINIDAD</b>: 2 ♀, Brasso Seco: 14.III.2015 (K. Sookdeo photograph, not collected). 1 ♀, Cumaca Road 0.5 mi: 27.X.1980, M.J.W. Cock [<i>leg.</i>], at MV Light (UWIZM CABI.2457). 3 ♀, Cumaca Road, 4.6 mi: 21.X.1982, M.J.W. Cock [<i>leg.</i>], at MV light (2 ♀ MWJC, 1 ♀ to be deposited USNM). 1 ♀, [Tabaquite]: [VI.1898], Kaye 1901, [lecto] type, BMNH (E)# 805414, NHMUK 010588329 (NHMUK). <b>FRENCH GUIANA:</b> 1 ♂, St. Jean du Maroni: 2.I.1978, T. Porion <i>leg.</i> [*provisionally identified as this species] (MNHN).</p>Published as part of <i>St Laurent, Ryan A. & Cock, Matthew J. W., 2017, Annotated list of Mimallonidae (Lepidoptera, Mimallonoidea) from Trinidad and Tobago, with the description of a new species of Cicinnus Blanchard, 1852 and taxonomic notes, pp. 53-70 in Zootaxa 4268 (1)</i> on pages 60-62, DOI: 10.11646/zootaxa.4268.1.3, <a href="http://zenodo.org/record/579898">http://zenodo.org/record/579898</a>
Early growth response gene-2 (Egr-2) regulates the development of B and T cells
No full textThe study was supported by Arthritis Research UK.
Copyright @ 2011 Li et al.BACKGROUND: Understanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development. METHODS AND FINDINGS: The expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2+ lymphocytes resulted in a severe reduction of CD4+CD8+ (DP) cells in thymus and pro-B cells in bone marrow, which was associated with reduced expression of Notch1 in ISP thymocytes and Pax5 in pro-B cells, suggesting that retraction of Egr-2 at the ISP and pro-B cell stages is important for the activation of lineage differentiation programs. In contrast to reduction of DP and pro-B cells, Egr-2 enhanced the maturation of DP cells into single positive (SP) T and NKT cells in thymus, and immature B cells into mature B cells in bone marrow. CONCLUSIONS: Our results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells.This article is provided by the Brunel Open Access publishing fund
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Long-Term Care Facility Residents with Dementia: Their COVID-19 Infection Hospitalization Outcomes
No full textLong-term care facilities (LTCF) were impacted disproportionately by the coronavirus (COVID-19), suggesting their high risk for community-spread pandemics. This three-article dissertation with publications aims to a) aggregate the emerging research evidence of factors for nursing home residents' COVID-19 infections; b) explore hospitalizations due to COVID-19 among emergency admissions and length of hospital stays for long-term care facility (LTCF) residents with dementia; and c). investigate how comorbidity index score mediates the relationship between COVID-19 hospitalization and discharge outcomes among LTCF residents with dementia. This dissertation consists of a three-article format: a mixed-methods systematic review and two retrospective cohort studies. The first study is a systematic review to summarize major factors of nursing home residents' COVID-19 infections over the pandemic period (January 1, 2020, to October 31, 2022) in the United States providing a context for the two empirical studies on COVID-19 hospitalization outcomes for LTCF residents with dementia. The second study is a cross-sectional study and utilizes Texas Inpatient Public Use Data File (PUDF) to compare COVID-19 hospitalization outcomes for LTCF residents with dementia aged over 60 years (n = 1,413) and those without dementia (n = 1,674) during period January 2020 to October 2022. Logistic regression is used to predict emergency admissions and length of hospital stay, with pre-existing conditions mediating the relationship. The third is a cross-sectional study and uses the same dataset and criterion from the second study. Logistic regression, mediation analysis, and moderation analysis are used to investigate the effect of comorbidity index score and health insurance status on the association between dementia status and place of live discharge, while controlling for sociodemographic factors such as age cohort, race, and gender. Findings from the mix-method systematic review of 48 articles yielded evidence to suggest risk factors associated with COVID-19 infections among nursing home residents in the USA by geography, demography, type of nursing home, staffing, resident's status, and COVID-19 vaccination status through 48 articles. The second study found that with COVID-19 hospitalization, a diagnosis of dementia and preexisting conditions was significantly associated with emergency admission (OR = 1.70; 95%CI = 1.40-2.06) and shorter hospital stays (OR = 0.64; 95%CI = 0.55-0.74) when considering, adjusting for confounders such as demographics, health insurance, and lifestyle. In the third study, dementia diagnosis with COVID-19 hospitalization increased the likelihood of discharge to hospice care (OR = 1.44, 95% CI = 1.16-1.80), followed by LTCF (OR = 1.42, 95% CI = 1.23-1.65), but decreased the likelihood of discharge to recovery hospitals (OR = 0.70, 95% CI = 0.52-0.94). The findings highlight the increased risk of COVID-19 hospitalization disparities among individuals with dementia. Targeted health support programs for LTCF residents with dementia would enhance their COVID-19 hospitalization outcomes. Discharge plans for COVID-19 patients with dementia should be customized to their care needs, including hospice care, to minimize healthcare disparities compared to other residents. Further study is needed as to why recovery hospitals are less preferred for live discharge of COVID-19 patients with dementia diagnosis
Drug resistance in ovarian cancer: The emerging importance of gene transcription and spatio-temporal regulation of resistance
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Clinical Applications in Molecular Targeted Therapy Timothy A Yap, Debashis Sarker, Stan B Kaye, and
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RoMEO Studies 2: How academics wish to protect their open-access research paper
No full textThis paper is the second in a series of studies (see Gadd, E., C. Oppenheim, and S. Probets. RoMEO Studies 1: The impact of copyright ownership on author-self-archiving. Journal of Documentation. 59(3) 243-277) emanating from the UK JISC-funded RoMEO Project (Rights Metadata for Open-archiving). It considers the protection for research papers afforded by UK copyright law, and by e-journal licences. It compares this with the protection required by academic authors for open-access research papers as discovered by the RoMEO academic author survey. The survey used the Open Digital Rights Language (ODRL) as a framework for collecting views from 542 academics as to the permissions, restrictions, and conditions they wanted to assert over their works. Responses from self-archivers and non-archivers are compared. Concludes that most academic authors are primarily interested in preserving their moral rights, and that the protection offered research papers by copyright law is way in excess of that required by most academics. It also raises concerns about the level of protection enforced by e-journal licence agreement
Parameter optimization of differential evolution algorithm for automatic playlist generation problem
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