1,720,956 research outputs found
Investigation of water-soluble coenzyme-Q10 combined with root extract of ashwagandha as a potential therapy for Alzheimer's Disease
No full textViable, Healthy and Safe CommunitiesAlzheimer's Disease (AD) is the most common form of dementia in Canada, currently affecting more than 500,000 Canadians. It is associated with a decline in neurocognitive function affecting memory and ability to perform daily tasks leading to severe morbidity. While therapies to reduce AD symptoms exist, there are no treatments that prevent its progression. Associated biochemical causes of AD include: increased oxidative stress, inflammation, mitochondrial dysfunction and accumulation dysfunctional protein leading to formation of plaques and neurofibrillary tangles. Current therapies are chemo-modulators where extended use has adverse effects. A multifaceted approach to treatment using natural compounds and extracts that can target multiple pathways simultaneously should be preferable. We hypothesize that combining Ubisol-Q10 and ashwagandha root extract to target mitochondrial dysfunction, oxidative stress, and inflammation could block the progression of AD. We propose to accomplish this using a double transgenic mouse model for AD, containing two defective genes (TgAPEswe, PSEN1dE9) that develop memory deficit and symptoms of AD. Four groups with the following feeding regiments 1) water 2) water-Ubisol-Q10 3) water-ashwagandha extract 4) water-UbisolQ10-ashwagandha extract will be maintained for 15 months. Animals will be tested for memory-related behaviour and will be sacrificed. Brain tissue will be analyzed by immunohistochemistry. Based on previous work, mice in group 4 should have improved memory. The brain tissues of these animals will be sectioned and stained for amyloid beta plaques. In addition, tissues will also be analyzed for oxidative stress, autophagy, and inflammation-related markers using specific antibodies. Ubisol-Q10 leads to significant loss of amyloid beta plaques and improvement in memory-related behaviour (previous results). The combination treatment should have a better outcome. If treatment with Ubisol-Q10 and ashwagandha extract shows better neuroprotective efficacy in the double transgenic AD mouse model, the combination should prove to be a promising therapeutic for those suffering from AD
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Experiential Learning is the Key to Enriching Student Success and Advancing Cancer Research Education
No full textN/ACancer is the leading cause of death in Canada, transcending all ages, genders, ethnicities, and socioeconomic status. However, many Canadians are unaware that cancer is a diverse set of diseases that require different diagnostic tools and treatment strategies. Thus, public education focusing on cancer research is critical to change the current conversation around the disease. The development of educational tools that engage and clearly illustrate the mechanisms of cancer research is a justified social need that requires proper training. It is hypothesized that university students immersed in cancer research and education through experiential learning become effective community educators. The Windsor Cancer Research Group (WCRG) offers many experiential learning opportunities for undergraduate and graduate students by connecting them to local researchers, health care professionals, patients and caretakers. To obtain an empirical measure of the program's success and needs for improvement, a survey was developed that investigates how these opportunities enrich technical and transferable skills, reinforce interest in biomedical careers, encourage students to be community educators and build self-efficacy. The survey has been distributed to current and past student participants of WCRG's experiential learning opportunities. After two weeks, results will be collected and assessed to obtain a better understanding of the effects of experiential learning while also demonstrating the impact of enhancing academic programs through experiential learning. Creating an accessible platform for the public to learn more about cancer research, and its impact on patient care also addresses a clear social need that promotes healthy and safe communities within Windsor-Essex
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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