1,733,939 research outputs found
Frontiers in Mechanochemistry and Mechanical Alloying
No full textThe book Frontiers in Mechanochemistry and Mechanical Alloying [ISBN : 97881-87053-69-8] (Rakesh Kumar, Srinivasan Srikanth and Surya Pratap Mehrotra (Eds.))is a compilation of papers presented in the VI International Conference on Mechanochemistry and Mechanical Alloying (INCOME) held at CSIR-National Metallurgical Laboratory (CSIR-NML), Jamshedpur (India) during December 1-4,2008 under the aegis of International Mechanochemistry Association (IMA). Fifty three papers (334 pp) included in this book are written by experts from all over the world
Proteolytic rewiring of the mitochondria in hypoxia
No full textMolecular oxygen sustains intracellular bioenergetics and is consumed by more than 400 biochemical reactions, making it essential for most species on Earth. Reduced oxygen concentration (hypoxia) is a major stressor that generally subverts life of aerobic species and is a prominent feature of pathological states encountered in inflammation, bacterial infection, cardiovascular defects, wounds, and cancer. Despite the fundamental importance of oxygen in human physiology and disease, we currently lack a complete understanding of how the mitochondrial proteome adapts fluctuations in oxygen tensions. We recently identify a mTORC1-LIPIN1-lipid signaling cascade that activates the i-AAA protease YME1L in hypoxia to ensure pyrimidine synthesis. Here, we determined protein turnover rates of mitochondrial proteins in hypoxia. The mitochondrial m-AAA protease AFG3L2 was found to reshape the mitochondrial matrix and inner mitochondrial membrane (IMM) proteome in hypoxia. This proteolytic rewiring affects various biological pathways, such as lipid metabolism, protein import, OXPHOS and metabolism. Hypoxia is one of the main stressors of the mTORC1, we investigated the role of mTORC1 in AFG3L2 dependent proteolytic rewiring. In nutrient starvation mTORC1 is inhibited and activates AFG3L2-dependent proteolytic rewiring, whereas active mTORC1 inhibits AFG3L2 activity. NCLX is a Na+/Ca2+ exchanger, which effluxes Ca2+ from the matrix in exchange for Na+ from the intermembrane space and loss of NCLX activates AFG3L2 -dependent proteolysis. We show that in hypoxia changes protein turnover, the mitochondrial m-AAA protease AFG3L2 reshapes the mitochondrial proteome to adapt to hypoxia
Correction to: Short- and long-term outcomes in infective endocarditis patients: a systematic review and meta-analysis
No full textCorrection Unfortunately, after publication of this article [1], it was noticed that the name of the fifth author was incorrectly displayed as Akshaya Srikanth Bahagavathula. The correct name is Akshaya Srikanth Bhagavathula and can be seen in the corrected author list above. The original article has also been updated to correct this error
A Robust Version of Heged\H{u}s's Lemma, with Applications
No full textHeged\H{u}s's lemma is the following combinatorial statement regarding
polynomials over finite fields. Over a field of characteristic and for a power of , the lemma says that any multilinear polynomial
of degree less than that vanishes at all
points in of some fixed Hamming weight must also
vanish at all points in of weight . This lemma was used by
Heged\H{u}s (2009) to give a solution to \emph{Galvin's problem}, an extremal
problem about set systems; by Alon, Kumar and Volk (2018) to improve the
best-known multilinear circuit lower bounds; and by Hrube\v{s}, Ramamoorthy,
Rao and Yehudayoff (2019) to prove optimal lower bounds against depth-
threshold circuits for computing some symmetric functions.
In this paper, we formulate a robust version of Heged\H{u}s's lemma.
Informally, this version says that if a polynomial of degree vanishes at
most points of weight , then it vanishes at many points of weight . We
prove this lemma and give three different applications.Comment: Published in STOC 2020. Changed affiliation in v2. v3: Revised in
accordance with comments from referees for TheoretiC
Frontiers in Mechanochemistry and Mechanical Alloying
No full textThe book Frontiers in Mechanochemistry and Mechanical Alloying [ISBN : 97881-87053-69-8] (Rakesh Kumar, Srinivasan Srikanth and Surya Pratap Mehrotra (Eds.))is a compilation of papers presented in the VI International Conference on Mechanochemistry and Mechanical Alloying (INCOME) held at CSIR-National Metallurgical Laboratory (CSIR-NML), Jamshedpur (India) during December 1-4,2008 under the aegis of International Mechanochemistry Association (IMA). Fifty three papers (334 pp) included in this book are written by experts from all over the world
Incidental Restrictions of Speech and the First Amendment: A Motive-Based Rationalization of the Supreme Court's Jurisprudence.
No full textSrinivasan, Srikanth. (1995). Incidental Restrictions of Speech and the First Amendment: A Motive-Based Rationalization of the Supreme Court's Jurisprudence.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/167238
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