125,119 research outputs found
Commendations of Governor Spry and his Replies, A-B
No full textSeries 2941 | Governor (1909-1917: Spry) | Joseph Hillstrom Correspondence | Commendations of Governor Spry and his Replies, A-BAs chief executive officer of the state, the governor has the authority to commute the sentences of those convicted of crimes. The conviction and execution of Joseph Hillstrom (Joe Hill) became one of the most controversial criminal cases in Utah history; it generated national and international interest. Correspondence is in the form of letters, postcards, and telegrams
B: Sept. 1-15, 1915
No full textSeries 2941 | Governor (1909-1917: Spry) | Joseph Hillstrom Correspondence | B: Sept. 1-15, 1915As chief executive officer of the state, the governor has the authority to commute the sentences of those convicted of crimes. The conviction and execution of Joseph Hillstrom (Joe Hill) became one of the most controversial criminal cases in Utah history; it generated national and international interest. Correspondence is in the form of letters, postcards, and telegrams
B: Oct.-Nov. 17, 1915
No full textSeries 2941 | Governor (1909-1917: Spry) | Joseph Hillstrom Correspondence | B: Oct.-Nov. 17, 1915As chief executive officer of the state, the governor has the authority to commute the sentences of those convicted of crimes. The conviction and execution of Joseph Hillstrom (Joe Hill) became one of the most controversial criminal cases in Utah history; it generated national and international interest. Correspondence is in the form of letters, postcards, and telegrams
Functional Interplay Between the B-box 2 and the B30.2(SPRY) Domains of TRIM5α
No full textThe retroviral restriction factors, TRIM5α and TRIMCyp, consist of RING and B-box 2 domains separated by a coiled coil from carboxy-terminal domains. These carboxy-terminal domains (the B30.2(SPRY) domain in TRIM5α and the cyclophilin A domain in TRIMCyp) recognize the retroviral capsid. Here we show that some B-box 2 changes in TRIM5α, but not in TRIMCyp, resulted in decreased human immunodeficiency virus (HIV-1) capsid binding. The phenotypic effects of these B-box 2 changes on the restriction of retroviral infection depended on the potency of restriction and the affinity of the TRIM5α interaction with the viral capsid, two properties specified by the B30.2 (SPRY) domain. Thus, some alterations in the TRIM5α B-box 2 domain apparently affect the orientation or conformation of the B30.2(SPRY) domain, influencing capsid recognition
William Spry
No full textWilliam Spry (Republican), shown with Emmeline B. Wells (far left) and other ladies, served as Goveror of Utah from 1909-1917. He is most known for securing funds to build the capitol and for his choice to not intervene in the famous Joe Hill murder case
B: July-Aug. 1914; Jan.-Aug. 1915
No full textSeries 2941 | Governor (1909-1917: Spry) | Joseph Hillstrom Correspondence | B: July-Aug. 1914; Jan.-Aug. 1915As chief executive officer of the state, the governor has the authority to commute the sentences of those convicted of crimes. The conviction and execution of Joseph Hillstrom (Joe Hill) became one of the most controversial criminal cases in Utah history; it generated national and international interest. Correspondence is in the form of letters, postcards, and telegrams
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Development of a European organization for research and treatment of cancer module to assess the quality of life of patients with proctitis after pelvic radiotherapy for malignancy
No full textNigel Spry, Georgia Halkett, Samar Aoun, Jane Spry and Eric Yeohhttp://www.elsevier.com/wps/find/journaldescription.cws_home/525471/description#descriptio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Structural and functional insights into the B30.2/SPRY domain
No full textThe B30.2/SPRY domain is present in similar to 700 eukaryotic (similar to 150 human) proteins, including medically important proteins such as TRIM5 alpha and Pyrin. Nonetheless, the functional role of this modular domain remained unclear. Here, we report the crystal structure of an SPRY-SOCS box family protein GUSTAVUS in complex with Elongins B and C, revealing a highly distorted two-layered beta-sandwich core structure of its B30.2/SPRY domain. Ensuing studies identified one end of the beta-sandwich as the surface interacting with an RNA helicase VASA with a 40 nM dissociation constant. The sequence variation in TRIM5 alpha responsible for HIV-1 restriction and most of the mutations in Pyrin causing familial Mediterranean fever map on this surface, implicating the corresponding region in many B30.2/SPRY domains as the ligand-binding site. The amino acids lining the binding surface are highly variable among the B30.2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif.X11112112sciescopu
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