125,046 research outputs found
First Captain Howard B. Sprinkle, Class of 1959, with Regimental Staff, fall 1958
No full textCadet First Captain Howard B. Sprinkle, Class of 1959 with members of the Regimental Staff for the 1958-59 academic year, ca. 1958. Left to right behind Sprinkle: Billy H. Kornegay, S-1; James J. Masotti, S-3; Leo A. Kramer, S-4, all Class of 1959.Folder contains additional photo
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Formulation Development of Modafinil Granules as Sprinkle Dosage Form
No full textModafinil were prepared by adding lactose monohydrate and partially pregelatinized starch in the intragranular stage. PVP was dissolved in purified water as a granulating agent and added the prepared solution to the dry mix blend which is suitable for granules form.
MCC was added, and most commonly used diluent for the solid oral dosage form. MCC was added in extragranular to enhance the flow property of the granules. Croscarmellose sodium was added as super disintegrant to enhance the disintegration time of the granules. Talc (0.5%) were used as anti-adherent in the investigation. It has good flow ability, high density and irregular surface property.
CHAPTER I:
In this introduction chapter discussed about sprinkle formulations, Types of sprinkle formulations, Tablets, Powders, Granules, Immediate Release capsules, Extended Release capsules, Delayed Release capsules and Multi-particulate drug delivery system, Preparation of Inclusion complex, Granulation and wet granulation.
CHAPTER II:
In this Chapter the literature related to this work was surveyed and a brief discussion had been given on each literature.
CHAPTER III:
The objective of present investigation was to develop the modafinil sprinkle dosage form by wet technique. Modafinil is mainly used as cocaine dependence with the dose of 100mg and BCS II drug with Low solubility and High Permeability. The oral route was chosen because of its excellent accessibility.
CHAPTER IV:
This Chapter gives an idea for the proposed plan of work that has to be carried out.
CHAPTER V& VI:
In this chapter information about the drug and the excipients used in the study was given.
CHAPTER VII & VIII:
This chapter deals with the materials and methods used in the study. This chapter covers the details including evaluation of preformulation, in vitro evaluation, and release kinetics in vitro, finally stability studies. Modafinil sprinkle were prepared by wet granulation technique. Accurately weighed solubilizer (HPβ-CD) and drug were transferred in the mortar and triturated the material for sufficient time (30 mins) and binder (PVP) were used as a granulating fluid and prepared the granules. The wet mass granules was then placed on the oven for sufficient time. Then added the MCC and CCS in the extragranular to enhance the flow property and disintegration time of the granules. According to that modafinil sprinkle were loaded on the sachet. The results were shown in Chapter 9.
CHAPTER IX & X:
This chapter depicts the results for the all tests indicated in the chapter VIII. The results for all the parameter to be evaluated for the prepared modafinil sprinkle. Modafinil were given in this chapter. The in-vitro & in use analysis testing evaluation of the optimized formulation were available. These chapters deal with the optimization of the formulation among the 5 batches of Modafinil sprinkle dosage form. The best values of the different evaluation test were found and presented in it. Dissolution studies of different formulation is tabulated and stability study was given. The chapter discussion involves in discussion of the better fit values of the different evaluation test to optimize the best fit values. A total of 5 trial formulations of modafinil sprinkle were proposed by using different molar ratio of HPβ-CD. The ratio of the drug and HPβ-CD differs for each batch the drug release were calculated by dissolution profile. Based on the observed dissolution data, the optimized formulation was identified and its evaluated by in vitro drug release the final formulation F5 were optimized. The influences of main effects (factors) on responses investigated optimized formulation fitted with selectively Peppas model to calculate the value of sum of squared residuals (SSR) and Akaike information criterion (AIC), best goodness-of-fit test (R2). High value of Mean selection criterion (MSE) was taken as criteria for selecting the most appropriate model. Accordingly, optimized formulation fitted with dissolution model and the values found to be (Table: 43) values found to be followed Korsemeyer - Peppas kinetics (Table: 47, 48, 49).
CONCLUSION:
The aim of the present research work was to develop sprinkle granules of Modafinil. Solubility and bitter taste of Modafinil improved by formation of complex with Hydroxypropyl Betacyclodextrin (HPß-CD). The complex prepared by kneading method. Molar ratio from 1:1 to 1:5 (F1-F5) used and solubility imcreaed from 0.4 μgm to 1.4 mg. Based on saturation solubility study,F3 and F5 batches used for characterization of complex by 1H-NMR , and F1 used for FTIR study, indicated inclusion compound formation was confirmed by the upfield shifts of H3 and H2 protons, located inside the cavity of β-CD and association constant was calculated using a nonlinear least-square regression analysis (0.843). In use analysis test explained F5 found to be compatible with five soft food and gave in vitro dissolution of 94% at 45 mts. Despite F5 batch gave better stability study, further investigation for taste masking using sensor to be carried out
NEW PARABLASTOIDS FROM THE WESTERN UNITED STATES
No full textTwo new genera and two new species of Parablastoidea are described from Early and Middle Ordovician faunas from the western United States. Eurekablastus n. gen. is similar in plating to Blastoidocrinus except that it possesses a conical pelvis with shallow basal cavity restricted to the basal circlet, one to two additional plate sets above the radials, medium to long cataspire slits, and lacks oral and ambulacral crests. Eurekablastus ninemilensis n. sp. from the Lower Ordovician Nimemile Shale of central Nevada and Eurekablastus rozhnovi n. sp. from the Lower Ordovician Wah Wah Limestone and uppermost Fillmore Formation of western Utah differ in thecal proportions, the number and distribution of interbrachial plates, the relative proportions of bibrachials and radials, and the length of the cataspire slits. Parabolablastus n. gen. is erected for Blastoidocrinus?? elongatus (Sprinkle), 1973, based on a mostly complete but crushed theca from the lower Middle Ordovician Antelope Valley Limestone of central Nevada. The plating in Parabolablastus may have been derived from Eurekablastus, but differs by having large parabolic deltoid plates, greatly enlarged bibrachials that form a complete circlet at the top of the pelvis and extend up into the vault interrays, and fewer or smaller plates in the lower pelvis. Blastoidocrinus? rossi Sprinkle, 1973, and B.? nevadensis Sprinkle, 1973, remain questionably assigned to Blastoidocrinus because they appear to have a high, fused, conical or cylindrical oral crest unlike the peristomial cover plates found in Eurekablastus and probably Parabolablastus
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Spectral engineering of LaF3:Ce3+ nanoparticles: The role of Ce3+ in surface sites
No full textDue to the high surface-to-volume ratio, luminescence centers on the surface have relative dominance in the overall spectral response of nanoparticles. The luminescence of LaF3:Ce3+ nanoparticles was investigated in the spectral and temporal domains with a particular focus on the role of Ce3+ on the surface. These nanoparticles present two luminescence bands at 4.10eV and 4.37 eV attributed to Ce3+ transitions from the 5d level to the spin-orbit split 4f ground levels F-2(5/2) and F-2(7/2), in addition to a low-energy band at 3.62 eV that has been attributed to Ce3+ ions residing in perturbed sites. The growth of up to three undoped shells, ca. 0.9 nm thick each, around the core promoted a progressive enhancement of luminescence output, concomitant with an increase in the fluorescence lifetime due to the weakening of energy transfer through multipolar interaction between Ce3+ in the core and quenching defects on the surface. Also, the growth of the first shell led to a decrease in the relative intensity of the low-energy band and a 0.23 eV shift to higher energies. These results were interpreted as being due to the existence of two types of perturbed sites, one on the surface that is eliminated by the growth of the first shell, and another within the volume of the nanoparticle, similar to observations in bulk single crystals. This work demonstrates how surface engineering can affect and control the luminescence behavior of this nanomaterial. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3700343
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