1,720,984 research outputs found
Activated human NK and CD8+ T cells express both TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptors, but are resistant to TRAIL-mediated cytotoxicity
No full textObesity and Protein kinase Cε epsilon expression in peripheral blood cells
No full textThe so-called Metabolic Syndrome is a clustering of metabolic disorders, including insulin resistance, obesity, hyperglycemia, dyslipidemia, and hypertension, mainly caused by overnutrition and sedentary lifestyles particularly in developed countries as well as genetic predisposition. Obesity, insulin resistance and type 2 diabetes are associated and caused by the upregulation of the protein kinase C (PKC)e expression in hepatic, adipose, pancreatic and skeletal tissue. It is well known that PKCe affects insulin receptor (IR) singaling and regulates both insulin secretion and clearance. Here, we have studied the expression levels of PKCe and IR in peripheral blood cells of obese children. Moreover, we have analyzed the correlation between PKCe/IR ratio with the BMI in adult underwent to high caloric food diet. As a final point, the role of PKCe as therapeutic target for management of obesity was discussed
Obesity and Protein kinase Cε epsilon expression in peripheral blood cells
No full textThe so-called Metabolic Syndrome is a clustering of metabolic disorders, including insulin resistance, obesity, hyperglycemia, dyslipidemia, and hypertension, mainly caused by overnutrition and sedentary lifestyles particularly in developed countries as well as genetic predisposition. Obesity, insulin resistance and type 2 diabetes are associated and caused by the upregulation of the protein kinase C (PKC)e expression in hepatic, adipose, pancreatic and skeletal tissue. It is well known that PKCe affects insulin receptor (IR) singaling and regulates both insulin secretion and clearance. Here, we have studied the expression levels of PKCe and IR in peripheral blood cells of obese children. Moreover, we have analyzed the correlation between PKCe/IR ratio with the BMI in adult underwent to high caloric food diet. As a final point, the role of PKCe as therapeutic target for management of obesity was discussed
TNF-related apoptosis-inducing ligand (TRAIL) and erythropoiesis: a role for PKCepsilon.
No full textThe regulation of the hematopoietic stem cell pool size and the processes of cell differentiation along the hematopoietic lineages involve apoptosis. Among the different factors with a recognized activity on blood progenitor cells, TRAIL - a member of the TNF family of cytokines - has an emerging role in the modulation of normal hematopoiesis.PKC(epsilon) levels are regulated by EPO in differentiating erythroid progenitors and control the protection against the apoptogenic effect of TRAIL. EPO-induced erythroid CD34 cells are insensitive to the apoptogenic effect of TRAIL between day 0 and day 3, due to the lack of specific surface receptors expression. Death receptors appear after day 3 of differentiation and consequently erythroid cells become sensitive to TRAIL up to day 9/10, when the EPO-driven up-regulation of PKC epsilon intracellular levels inhibits the TRAIL-mediated apoptosis, via Bcl-2. In the time interval between day 3 and 9, therefore, the number of erythroid progenitors can be limited by the presence of soluble or membrane-bound TRAIL present in the bone marrow microenvironment
Hypoxia-induced down-modulation of pkc epsilon increases trail-mediated apoptosis of tumor cells
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