13,714 research outputs found
Lo spirito dello haiku
No full textNel primo saggio che compone questo volume, Lo spirito dello haiku, Torahiko Terada esalta la qualità del componimento poetico breve, capace di evocare un mondo in poche righe. Quelli che agli occidentali possono apparire come semplici quadretti naturalistici sono in realtà il tentativo di tradurre in versi un’immagine, una sensazione fugace, risvegliando nella mente del lettore una serie infinita di associazioni. La rigorosa struttura formale non è percepita come un limite, ma come un dispositivo attraverso il quale affinare la capacità di percepire la natura e riflettere su sé stessi.
Ne I miei ricordi del professor Natsume Sōseki, Terada fa rivivere la figura del maestro, dagli anni di scuola fino alla sua morte. Sōseki non è soltanto il professore di inglese: è soprattutto la guida che lo accompagna nell’arte dello haiku e nella vita. È il confidente a cui chiedere consiglio nei momenti di sconforto e difficoltà, ma anche un intellettuale anticonformista, a tratti permaloso, capace di stimolare la curiosità e l’interesse degli allievi che lo circondano. Ne risulta un ritratto spontaneo e vivace, affettuoso e ironico insieme, di uno dei massimi scrittori giapponesi contemporanei
N-acetyl-l-cysteine fosters inactivation and transfer to endolysosomes of c-Src
No full textThe non-receptor-protein tyrosine kinase c-Src is overexpressed and activated in a large number of human
cancers, in which it is associated with tumor development and progression. Canonical regulation takes place
by means of an alternative phosphorylation of tyrosine residues Tyr419 for activation and Tyr530 for
inactivation. An independent redox regulation mechanism, involving cysteine residues, has also been
proposed, in which oxidation activates the enzyme. Here we present a kinetic analysis of the effect of
N-acetyl-l-cysteine (NAC) on c-Src, demonstrating that reduction reverts the oxidation-driven activation. In
cancer cells, we show that NAC treatment produces an increase in specifically labeled reduced thiols of c-Src
cysteines, thus confirming a redox transition. In addition to a decrease in Tyr419 phosphorylation, this leads
to a massive shift of c-Src from plasma membranes where its active form is located to endolysosomal
compartments. With the objective of deciphering the complex issue of c-Src regulation and of devising new
strategies to revert its activation in cancers, redox regulation thus emerges as a promising area for study
CpG oligodeoxinucleotides promote phospholipase D despendent phagolysosome maturation and intracellular mycobacterial killing in M. tubercolosis infected type II alveolar epithelial cells
No full textCpG oligodeoxynucleotides have been previously shown to enhance antimycobacterial response in
human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides
to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen
intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent
intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing
that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial
immune response
Ingegno creativo e spirito dell'infanzia
No full textLo spirito dell'infanzia come straordinaria capacità di stupirsi, pensare e creare, che accomuna il ragazzo allo scienziato al filosofo. Tra gli autori trattati Nietzsche, Freud, Darwin, Einstein, Newton. Confronti e parallelli anche con i fumetti di Disney, Hergé, Jacobs e altri
Folco Martinazzoli, La « successio » di Marco Aurelio. Struttura e spirito del primo libro dei « Pensieri »
No full textMertens Paul. Folco Martinazzoli, La « successio » di Marco Aurelio. Struttura e spirito del primo libro dei « Pensieri ». In: L'antiquité classique, Tome 21, fasc. 2, 1952. pp. 447-449
Folco Martinazzoli, La « successio » di Marco Aurelio. Struttura e spirito del primo libro dei « Pensieri »
No full textMertens Paul. Folco Martinazzoli, La « successio » di Marco Aurelio. Struttura e spirito del primo libro dei « Pensieri ». In: L'antiquité classique, Tome 21, fasc. 2, 1952. pp. 447-449
Topological properties of semigroup primes of a commutative ring
No full textA semigroup prime of a commutative ring R is a prime ideal of the semigroup (R, ·). One of the purposes of this paper is to study, from a topological point of view, the space S(R) of prime semigroups of R. We show that, under a natural topology introduced by B. Olberding in 2010, S(R) is a spectral space (after Hochster), spectral extension of Spec(R) , and that the assignment R⦠S(R) induces a contravariant functor. We then relateâin the case R is an integral domainâthe topology on S(R) with the Zariski topology on the set of overrings of R. Furthermore, we investigate the relationship between S(R) and the space X(R) consisting of all nonempty inverse-closed subspaces of Spec(R) , which has been introduced and studied in Finocchiaro et al. (submitted). In this context, we show that S(R) is a spectral retract of X(R) and we characterize when S(R) is canonically homeomorphic to X(R) , both in general and when Spec(R) is a Noetherian space. In particular, we obtain that, when R is a Bézout domain, S(R) is canonically homeomorphic both to X(R) and to the space Overr(R) of the overrings of R (endowed with the Zariski topology). Finally, we compare the space X(R) with the space S(R(T)) of semigroup primes of the Nagata ring R(T), providing a canonical spectral embedding X(R) âa S(R(T)) which makes X(R) a spectral retract of S(R(T))
Physical Properties of the Zona Pellucida
No full textThe zona pellucida (ZP) is the extracellular coat that surrounds the mammalian oocyte. It forms a spherical shell of remarkably uniform thickness (5-10 mm in eutherian mammals) composed of three glycosylated proteins (ZP1, ZP2 and ZP3). Penetration of this shell by spermatozoa plays a crucial role in mammalian fertilization and any inability of spermatozoa to penetrate the ZP inevitably leads to infertility. The purpose of this work is to shed light to the three-dimensional structure of the ZP, its construction and its properties as a polymer. By means of the Atomic Force Microscopy (force-distance curves) we have determined for the first time several ZP structural properties (elasticity, plasticity,
adhesion, etc.) during the ovulatory, periovulatory and fertilized phase.
Moreover information about single polymers interactions has been obtained by means detachment experiments (pull-off curves)
Lo "spirito di Assisi" alla prova della storia
No full textIl saggio indaga le origini e lo sviluppo del cosiddetto "spirito di Assisi", nato dalla convocazione nella città umbra dei leader religiosi mondiali da parte di Giovanni Paolo II nel 1986. Si trattò di un evento inedito dalla rilevanza non solo religiosa e interna ai mondi della fede ma pure storica e geopolitica. In uno scenario ancora segnato dalla guerra fredda le religioni desolidarizzano dalla guerra e dal ricorso alla violenza proclamando il valore della pace
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