2,446 research outputs found
'Turm in Flammen' – Ausstellung im Tübinger Hölderlinturm
No full textUnser Thema heute: Der Brand im Tübinger Hölderlinturm am 14. Dezember 1875. Ulrich Hägele hat dazu zwei Gäste ins Studio eingeladen. Sie sind diesem alten Kriminalfall auf der Spur gewesen: Florian Mittelhammer, Leiter des Museums im Hölderlinturm und Steffi Schleicher. Sie studiert Medienwissenschaft im Master und hat im Hölderlinmuseum ein wissenschaftliches Praktikum absolviert. Zu sehen sind die Ergebnisse der Recherchen im Hölderlinturm in der Ausstellung »Turm in Flammen die Fahndungsakte Feuerteufel«.
Der Dichter Friedrich Hölderlin hatte in dem Gebäude von 1807 bis zu seinem Tod 1843 gelebt. Die Inneneinrichtung war vor dem Brand 1875 noch weitgehend erhalten.
Die Gerüchte um eine mutmaßliche Brandstiftung, die sich kurze Zeit nach der Tat in Tübingen herumsprachen, beflügelten die Fantasie des Schriftstellers Bruno Wille (1860-1928). Als Jugendlicher hatte er den Brand miterlebt. Später erlangte er unter anderem als Gründer der Berliner Volksbühne Berühmtheit.
In seinem autofiktionalen Roman »Der Glasberg« erinnerte sich Wille an seine Jugendjahre in Tübingen. Er beschreibt akkurat die Vorkommnisse der Brandnacht und erzählt, wenn auch in etwas abgewandelter Form, vom Streit zwischen Eberhardt (im Roman Spengler), der im Haus wohnte und dem Nachbarn Bez, der vis-à-vis in der Bursagasse eine Gastwirtschaft mit Brauerei betrieb. Im zweiten Teil der Sendung zu hören ist eine Passage aus dem Roman »Der Glasberg«, bearbeitet von Florian Mittelhammer und Steffi Schleicher. Es sprechen Gilbert Mieroph und Ulrich Hägele
Interferon-λ4 (IFNL4) transcript expression in human liver tissue samples.
No full textEradication of hepatitis C virus (HCV) infection, both spontaneous and treatment-induced, is marked by the wildtype allele C of a single nucleotide polymorphism upstream of the IL28B gene, rs12979860. This favorable allele was recently described to be in linkage disequilibrium with the wildtype allele TT of a dinucleotide polymorphism, ss469415590, located within a new protein-coding gene. While the TT allele introduces a frame-shift and disrupts the open reading frame, only the variant allele, ΔG, creates a novel type III interferon (IFN) protein, IFN-λ4/IFNL4. Absence of IFNL4 is thus supposed to favor resolution of HCV infection. As to date IFNL4 mRNA transcription has only been investigated in polyI:C-stimulated primary human hepatocytes and not yet in HCV infection in vivo, this study analyzed IFNL4 mRNA expression in human liver biopsy specimens. Samples were obtained from patients with a broad panel of disorders including no liver disease, liver diseases of non-viral etiology, chronic hepatitis B and chronic hepatitis C. Hepatic IFNL4 transcripts were detectable exclusively in a subgroup of chronic hepatitis C patients (24/45). Their amounts were positively related to liver HCV RNA copy numbers (p = 0.0023, r = 0.56) suggesting that the hepatic viral load influences IFNL4 transcription irrespective of IFNL4 governing genotype. Both, the IFNL4 creating allele ΔG (p<0.0001) and actual IFNL4 transcription (p = 0.0015) were found to be correlated to the activation of IFN stimulatory genes (ISGs). By contrast, IFNL4 ss469415590 genotypes were not found to be related to IFN-λ2/3/IL28 or IFN-λ1/IL29 gene expression. In conclusion, this study is the first report on intrahepatic transcript levels of the recently discovered IFNL4 gene. Data indicate that HCV infection in particular might activate IFNL4 transcription in the liver. It provides a possible explanation as to why hepatitis C patients show ISG stimulation in their livers in the apparent absence of an induction of other IFN subtypes
Does the interferon-lambda rather than the interferon-alpha pathway determine the outcome of hepatitis C virus infection?
No full textThe molecular mechanisms that link IFN-lambda 3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-lambda and of the specific IFN-lambda receptor chain (IFN-lambda R1) in 122 liver biopsies of patients with CHC and 53 control samples. The IFN-lambda 3 genotype was not associated with differential expression of IFN-lambda, but rather IFN-lambda R1. In a series of 30 primary human hepatocyte (PHH) samples, IFN-lambda R1 expression was low but could be induced with IFN-alpha. IFN-alpha-induced IFN-lambda R1 expression was significantly stronger in PHHs carrying the minor IFN-lambda 3 allele. The analysis of liver biopsies of patients with CHC revealed a strong association of high IFN-lambda R1 expression with elevated ISG expression, with IFN-lambda 3 minor alleles, and with nonresponse to pegylated IFN-alpha and ribavirin. The findings provide a missing link between the IFN-lambda 3 genotype and the associated phenotype of treatment nonresponse
Ulrich von Wilamowitz-Moellendorff, Il tramonto dell’Antichità
No full textAgli anni immediatamente successivi alla Grande guerra risalgono le riflessioni di Ulrich von Wilamowitz-Moellendorff sulle cause che determinarono la decadenza della civiltà classica greco-romana. Il testo più significativo al proposito è la conferenza intitolata "Der Untergang des Altertums" (Il tramonto dell'antichità), tenuta in più occasioni e pubblicata nel 1926. In questa conferenza, tradotta in italiano, il grande filologo classico si muove nel solco di una tradizione di studi che aveva avuto nel "Tramonto dell'occidente" di Oswald Spengler il vertice più influente e controverso. La particolarità dell'analisi di Wilamowitz sul declino del mondo antico è data dal costante confronto analogico con l'attualità. Vi si riflettono i suoi sentimenti di totale disillusione e profonda frustrazione generati dalla catastrofe bellica del popolo tedesco, dal crollo dell'impero guglielmino e dall'avvento di un'epoca nuova in cui egli non poteva riconoscersi
Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum
No full textTRACTATIO IURIS PUBLICI DE SERENISSIMIS POTENTISSIMISQUE DUCIBUS BRUNSVICENSIBUS ET LUNEBURGENSIBUS / D.O.M.A. PRAESIDE ... DN. JOH. ULRICO PREGIZERO ... IN ILLUSTRI COLLEGIO AD DIEM 10. DECEMBR. PLACIDO ERUDITORUM EXAMINI SISTIT AUTHOR CHRISTIAN ULRICH BLUM
Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum (1)
Titelblatt (1)
Prooemium. (3)
Caput I. (5)
Caput II. (9)
Caput III. (12)
Caput IV. (22)
Caput V. (29)
Caput VI. (47)
I. - V. (54
Johann Fischart. Sämtliche Werke. Bd. II: Eulenspiegel reimenweis
No full textSeelbach U, Spengler WE, eds. Johann Fischart. Sämtliche Werke. Bd. II: Eulenspiegel reimenweis. Stuttgart-Bad Cannstatt: Frommann-Holzboog; 2002
Zum Verhältnis zwischen Harry Graf Kessler, Oswald Spengler und dem Nietzsche-Archiv
No full textSaggio sul rapporto tra Harry Graf Kessler, Oswald Spengler e il Nietzsche-Archiv
sj-pdf-1-erp-10.1177_08902070211062326 – Supplemental Material for The longitudinal interplay of personality and school experiences in adolescence
No full textSupplemental Material, sj-pdf-1-erp-10.1177_08902070211062326 for The longitudinal interplay of personality and school experiences in adolescence by Anne Israel, Naemi D Brandt, Marion Spengler, Richard Göllner, Oliver Lüdtke, Ulrich Trautwein and Jenny Wagner in European Journal of Personality</p
Ulrich von Wilamowitz-Moellendorff, Il tramonto dell’Antichità e altri scritti, a cura di G. Ugolini e E. Simeone
No full textTra il 1920 e il 1922 Ulrich von Wilamowitz, tra i più grandi filologici classici di tutti i tempi, tenne una serie di conferenze sul tramonto dell’antichità. Il tema era certo molto attuale. Intellettuali e studiosi europei, già prima che iniziasse il primo conflitto mondiale, avevano indagato la fine del mondo antico (Otto Seeck, per esempio, ma anche Eduard Meyer e Eduard Schwartz): nel primo dopoguerra, in seguito all’uscita dell’opera di Spengler, la decadenza dell’antichità era ormai diventata il paradigma della fine della civiltà occidentale. Wilamowitz ne è consapevole, e non manca di alludere, con una certa ironia, al Tramonto dell’Occidente di Spengler. Per il filologo classico, il crollo cominciò con Augusto; e a uccidere l’impero non furono gli assalti esterni, quelli dei barbari, bensì l’esaurimento della vitalità interna, determinato dall’estinzione del tradizionale ceto senatorio, sostituito nella funzione di leadership da esponenti dei ceti bassi che riuscirono ad affermarsi negli apparati della burocrazia militare e amministrativa. È innegabile che il prussiano Wilamowitz sappia cogliere, nella Spätantike, numerose analogie con la temperie presente, come è altrettanto innegabile che, nelle sue analisi e nelle sue analogie, tradisca motivi ideologici di inizio Novecento: in primis il disprezzo per le masse e per la democrazia
Supplementary movies of the dynamic rupture and tsunami models published in Ulrich et al. (2019)
No full text<p>Supplementary movies of the dynamic rupture and tsunami models published in Ulrich et al. (2019)</p>
<p>movie_Sulawesi_SR-cp.mov: Absolute slip rate (m/s) across the fault network during the earthquake. Author: Thomas Ulrich</p>
<p>movie_Sulawesi_wavefield-cp.mov: Absolute slip rate (m/s) and wavefield (absolute particle velocity in m/s) across the fault network during the earthquake. Author: Thomas Ulrich</p>
<p>SulawesiTanioka.mp4: Sea surface height (m) predicted by the tsunami scenario. Author: Stefan Vater</p>
<p>reference: Ulrich, T., Vater, S., Madden, E. H., Behrens, J., van Dinther, Y., van Zelst, I., Fielding, E. J., Liang, C. & Gabriel, A. A. (2019). Coupled, Physics-based Modeling Reveals Earthquake Displacements are Critical to the 2018 Palu, Sulawesi Tsunami. doi: 10.31223/osf.io/3bwqa.</p>
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