1,568 research outputs found
Paper Illustrations with Author Lindsay Ward
No full textMeet Lindsay Ward, author and illustratior of When Blue Met Egg . Lindsay will talk about her children\u27s book and then show kids in grades 3-5, how to create illustrations out of cut paper and mixed media. Bring her book if you would like an autograph
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling
Get PDFLindsay C Spender, Gareth J Inman Division of Cancer Research, Medical Research Institute, Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK Abstract: Burkitt's lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proliferation tempered by high levels of apoptosis. Despite the high levels of cell death, the net effect is one of rapid tumor growth. The tumor arises within the germinal centers of secondary lymphoid tissues and is identifiable by translocation of the c-MYC gene into the immunoglobulin gene loci, resulting in deregulation of the proto-oncogene. Many of the major players involved in determining the development of BL have been characterized in human BL cell lines or in mouse models of MYC-driven lymphomagenesis. Both systems have been useful so far in characterizing the role of tumor suppressor genes (for example, p53), prosurvival signaling pathways, and members of the B-cell lymphoma-2 family of apoptosis regulators in determining the fate of c-MYC overexpressing B-cells, and ultimately in regulating lymphoma development. Signaling through phosphoinositide (PI)3-kinase stands out as being critical for BL cell survival. Recurrent mutations in ID3 or TCF3 (E2A) that promote signaling through PI3-kinase have recently been identified in human BL samples, and new therapeutic strategies based on coordinately targeting both the prosurvival factor, B-cell lymphoma-XL, and the PI3-kinase/AKT/mammalian target of rapamycin (mTOR) signaling pathway to synergistically induced BL apoptosis have been proposed. Now, engineering both constitutive c-MYC expression and PI3-kinase activity, specifically in murine B-cells undergoing the germinal center reaction, has revealed that there is synergistic cooperation between c-MYC and PI3-kinase during BL development. The resulting tumors phenocopy the human malignancy, and acquire tertiary mutations also present in human tumors. This model may, therefore, prove useful in further studies to identify functionally relevant mutational events necessary for BL pathogenesis. This review discusses these cooperating interactions, the possible influence of BL tumor-associated viruses, and highlights potential new opportunities for therapeutic intervention. Keywords: Burkitt's lymphoma, c-MYC, PI3-kinase, AKT, mTOR, Epstein–Barr viru
Longitudinal patterns of behavioral, emotional, and social difficulties and self-concept in adolescents with a history of specific language impairment
Get PDFPurpose: This study explored the prevalence and stability of behavioral difficulties and self-concepts between 8 and 17 years in a sample of children with a history of specific language impairment (SLI). We investigated whether earlier behavioral, emotional and social difficulties (BESD), self-concepts, language, and literacy abilities predicted behavioral difficulties and self-concepts at 16/17 years.
Method: In this prospective longitudinal study, 65 students were followed up with teacher behavior ratings and individual assessments of language, literacy, and self-concepts at 8, 10, 12, 16, and 17 years.
Results: The students had consistently higher levels of five domains of BESD, which had different trajectories over time, and poorer scholastic competence, whose trajectory also varied over time. Earlier language ability did not predict later behavioral difficulties or self-concepts but the prediction of academic self-concept at 16 by literacy at 10 years approached significance.
Conclusions: We demonstrate the importance of distinguishing domains of behavioral difficulties and self-concept. Language, when measured at 8 or 10 years, was not a predictor of behavior or self-concepts at 16 years, or of self-concepts at 17 years. The study stresses the importance of practitioners addressing academic abilities and different social-behavioral domains in delivering support for adolescents with SLI
Dr. Katherine Lindsay
No full textPhotograph of Dr. Katherine "Kate" Lindsay standing next to a rose bush. According to a verso note, this photograph was taken at a Sanitarium in Boulder, Colorado.
Katharine “Kate” Lindsay was the first female Seventh-day Adventist physician and medical missionary. An educator, professor, and author, Lindsay was a leader in the development of the first Seventh-day Adventist school of nursing.
At the age of eighteen, she enrolled in an institution in New Jersey that provided training to nurses. She graduated two years later and went on to the University of Michigan where she graduated with a medical degree around 1875. Lindsay went on an overseas mission to South Africa, where she assisted medical and nursing staff. When she returned to the United States in 1900, Lindsay was called to serve at the Colorado Sanitarium in Boulder, Colorado. For twenty years, she was an active member
of the sanitarium medical staff and faculty. Lindsay was eighty years old when she died in her home on March 31, 1923.
In 1936, the College of Medical Evangelists (now Loma Linda University) Board of Trustees, upon recommendation by their School of Nursing faculty, named the original 1910 Loma Linda “girls’ dormitory,” Kate Lindsay Hall.9 x 14 c
Malaysian author Kemala talks with famous Australian poet Professor A.D. Hope during his visit to the Australian National Playwrights Conference in Canberra, 1973 [picture] /
No full textCondition: Good, glued to card.; Inscriptions: "Joint writing venture brings Malaysian author to Australia. Malaysian author Ahmad Kamal Abdulla arrived in Canberra, Australia's national capital, on March 6 as part of a three-week visit to Australia to obtain Australian Government assistance for joint works between Australian and Malaysian writers. During his visit the author, who writes under the name Kamala, held talks with the Australian Council for the Arts and the Australian Commonwealth Literary Fund and met several Australian playwrights and poets who appeared in favour of the idea. In Canberra he attended the Australian National Playwrights Conference at the Australian National University and visited the Canberra College of Advanced Education. Kemala, who is secretary of Gapena, the Malaysian National Writers Federation, also visited Sydney, Melbourne, Adelaide and Perth."--Printed on label on reverse.; News and Information Bureau biographical note attached to record vn3664293.; Title devised by cataloguer from inscription on reverse.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3664392
Dr. Katherine Lindsay
No full textKatharine “Kate” Lindsay was the first female Seventh-day Adventist physician and medical missionary. An educator, professor, and author, Lindsay was a leader in the development of the first Seventh-day Adventist school of nursing.
At the age of eighteen, she enrolled in an institution in New Jersey that provided training to nurses. She graduated two years later and went on to the University of Michigan where she graduated with a medical degree around 1875. Lindsay went on an overseas mission to South Africa, where she assisted medical and nursing staff. When she returned to the United States in 1900, Lindsay was called to serve at the Colorado Sanitarium in Boulder, Colorado. For twenty years, she was an active member of the sanitarium medical staff and faculty. Lindsay was eighty years old when she died in her home on March 31, 1923.
In 1936, the College of Medical Evangelists (now Loma Linda University) Board of Trustees, upon recommendation by their School of Nursing faculty, named the original 1910 Loma Linda “girls’ dormitory,” Kate Lindsay Hall.10.5 x 15 c
Dr. Katherine Lindsay
No full textKatharine “Kate” Lindsay was the first female Seventh-day Adventist physician and medical missionary. An educator, professor, and author, Lindsay was a leader in the development of the first Seventh-day Adventist school of nursing.
At the age of eighteen, she enrolled in an institution in New Jersey that provided training to nurses. She graduated two years later and went on to the University of Michigan where she graduated with a medical degree around 1875. Lindsay went on an overseas mission to South Africa, where she assisted medical and nursing staff. When she returned to the United States in 1900, Lindsay was called to serve at the Colorado Sanitarium in Boulder, Colorado. For twenty years, she was an active member
of the sanitarium medical staff and faculty. Lindsay was eighty years old when she died in her home on March 31, 1923.
In 1936, the College of Medical Evangelists (now Loma Linda University) Board of Trustees, upon recommendation by their School of Nursing faculty, named the original 1910 Loma Linda “girls’ dormitory,” Kate Lindsay Hall.13 x 18 c
Dr. Katherine Lindsay
No full textKatharine “Kate” Lindsay was the first female Seventh-day Adventist physician and medical missionary. An educator, professor, and author, Lindsay was a leader in the development of the first Seventh-day Adventist school of nursing.
At the age of eighteen, she enrolled in an institution in New Jersey that provided training to nurses. She graduated two years later and went on to the University of Michigan where she graduated with a medical degree around 1875. Lindsay went on an overseas mission to South Africa, where she assisted medical and nursing staff. When she returned to the United States in 1900, Lindsay was called to serve at the Colorado Sanitarium in Boulder, Colorado. For twenty years, she was an active member
of the sanitarium medical staff and faculty. Lindsay was eighty years old when she died in her home on March 31, 1923.
In 1936, the College of Medical Evangelists (now Loma Linda University) Board of Trustees, upon recommendation by their School of Nursing faculty, named the original 1910 Loma Linda “girls’ dormitory,” Kate Lindsay Hall.6 x 10.5 c
Alexis Lindsay Interview, October 30, 2013
No full textSUMMARY OF INTERVIEW: In this interview, Claire Davis talks with Alexis Lindsay, the Special Events and Communications Manager at Covenant House Washington. Ms. Lindsay talks about why youth come to Covenant House and the demographics of the homeless youth population in Washington, DC. Ms. Lindsay also reflects on how to end youth homelessness and the types of services that Covenant House Washington provides for youth. PROJECT’S OBJECTIVES: The interviews conducted as part of the DC Oral History and Social Justice Project record how unhoused residents of the greater DC area view the history of homelessness – how did homelessness become such an entrenched part of the city. The interviews will be used to create critical dialogue among people who are currently unhoused in Washington, DC, and then they may be used to assist future advocacy efforts
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