1,747,442 research outputs found
Ecological Goods and Services Survey Summary Prepared for: Lower Souris Watershed Committee
Get PDFAn interview based survey of farm landowners in the south east corner of Saskatchewan was undertaken to evaluate the provision of wildlife habitat by agriculture. Producers were asked to provide management information regarding a piece of their land that was managed as a unit. Within the past ten years there has been a reduction in the conversion of remaining native land to crop land, an increase in conversion of annual crop land to perennial cover crops, an increase in the use of minimum disturbance (no-till) farming, and a decrease in the use of fire on stubble fields and sloughs. Many producers in the area often stated economic reasons for their current land use division. Even ecological reasons (productive capacity of the soil, poor cropping soil, light soil etc.) often had an economic basis. If the land was not productive enough, a management scheme with lower input costs would be adopted. This was commonly demonstrated in this survey by the conversion of marginal land to tame forages. Producers within this region seem willing to adopt farming practices that connect economic sustainability with environmental responsibility. This survey is part of an-on going study of the region.Land Use, Tillage, Crop Production/Industries, Environmental Economics and Policy, Land Economics/Use, Q150, Q240,
Interview with former Michigan Supreme Court Justice Theodore Souris
No full textMichigan Supreme Court Justice Theodore Souris discusses his family history, living in Detroit and then Ann Arbor as a student, joining the Air Force in 1943, and finally returning to the University of Michigan in 1945 to finish his undergraduate degree and complete law school. Souris also talks about knowing Michigan legends G. Mennen Williams and Neil Staebler, practicing law after graduating, being involved in the election recounts of 1950 and 1952, and his unexpected appointment to the Michigan Supreme Court. Souris says that his first weeks on the Court were challenging, but that he worked quickly to initiate needed changes in such matters as the process of acquiring copies of briefs and creating "Window Reports." He also weighs in on the statistical analyses of the Court's work, court processes, writing opinions, the relationships of Justices during his tenure and the work of such colleagues as Justices Talbot Smith and George Edwards. The Michigan Supreme Court confronted many thorny legal issues during his time, Souris says and chief among these were Michigan court reform, the one-man grand jury law, government immunity, presumption of undue influence, summary judgment, and the right of discovery. Souris discusses each and how such cases and court decisions affect the creation and revision of laws.See the Michigan Supreme Court Historical Society website for more information on the life of Theodore Souris.Image courtesy of the Michigan Supreme Court Historical Society.Interviewed by Roger F. Lane at Renaissance Center, Detroit, MI, Nov. 5, 1990.Digital remastering of analog cassettes originally recorded for "Interviews with Michigan Supreme Court Justices," sponsored by the Michigan Supreme Court Historical Society
Les marqueurs de prolifération en oncologie vétérinaire : applications à l'étude pronostique du mastocytome cutané canin
Get PDFLe mastocytome cutané représente un type tumoral dominant de la cancérologie du chien mais demeure l'une des tumeurs canines au comportement clinique les plus imprévisibles. L'auteur évalue dans une étude rétrospective portant sur 120 chiens porteurs de mastocytome cutané, la valeur pronostique de la détection immunohistochimique des marqueurs de prolifération PCNA et Ki-67. Il montre que la détermination de l'expression de l'antigène Ki-67 permet de prédire avec une grande fiabilité l'évolution clinique post-chirurgicale de ce type tumoral
Replication Data for: Laos SavGIS Database
No full textLaos SavGIS database is a geodatabase available for use with SavGIS software for scientific research on Laos
Replication Data for: Europapolitik im föderalen Haus. Abstimmungsverhalten im Ausschuss für Fragen der Europäischen Union des Bundesrates
No full textDer Datensatz enthält 99.200 individuelle Abstimmungsentscheidungen der 16 Länderbeauftragten im EU-Ausschuss des deutschen Bundesrates in 6.220 Abstimmungen über die Empfehlungen zu 2.000 Vorlagen in den drei Wahlperioden des Bundestages (15, 16 und 17) zwischen Oktober 2002 und Oktober 2013
Replication Data for: Laos SavGIS Database
No full textLaos SavGIS database is a geodatabase available for use with SavGIS software for scientific research on Laos
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Russian popular songs : rousskiya pesni / N. Balieff's Chauve-souris company, ens. voc. ; with the Cambridge theatre orchestra ; conducted by Archangelsky. Gipsy caravan / N. Balieff's Chauve-souris company, ens. voc. ; with guit.
No full text[Traditions. Europe. Russie]Comprend : Russian popular songs / N. Balieff's Chauve-souris company, ens. voc. ; with the Cambridge theatre orchestra ; conducted by Archangelsky ; Gipsy caravan / N. Balieff's Chauve-souris company, ens. voc. ; with guit
Caractérisation génétique et fonctionnelle de la sensibilité et de la résistance innées au virus Zika chez la souris
No full textInfection of humans by Zika virus (ZIKV) can result in variable outcomes, from the absence of clinical symptoms to severe neurological complication or microcephaly after intra-uterine infection. Using the Collaborative cross, a collection of mouse inbred strains with large genetic diversity, my lab has previously demonstrated for the first time the importance of host genetic factors in this clinical variability, and identified CC071 as the most susceptible strain, with high viral loads in the blood, severe symptoms and mortality.During my PhD thesis, I have first investigated the genetic origin of CC071's susceptibility using an in vitro model. Mouse embryonic fibroblasts (MEFs) from CC071 showed enhanced viral replication associated with delayed induction of type-I interferons (IFN-I). A quantitative trait locus (QTL) mapping analysis on MEFs derived from a backcross between CC071 and the resistant strain CC001 led to the identification of a loss of function mutation in the Irf3 gene, specific to CC071. Functional analyses demonstrated that this mutation fully explains the defective IFN-I induction and uncontrolled viral replication in CC071 MEFs. However, after in vivo ZIKV infection, CC071 mice exhibited higher susceptibility than C57BL/6J (B6) Irf3 KO mice, demonstrating the involvement of other susceptibility genes in the disease of CC071 mice in vivo.To identify such genes, I analyzed a backcross between CC071 and B6 Irf3 KO, and an F2 between CC071 and 129/SvPas (129) Ifnar1. Their analysis led to the identification of six significant QTLs and twenty-three suggestive QTLs, associated with the viral load, body weight loss, clinical symptoms, and mortality.I also investigated the loci which modify the susceptibility to ZIKV infection of Ifnar1 KO mice. This KO exists on two genetic backgrounds, and my laboratory previously demonstrated that B6 Ifnar1 KO mice are more susceptible to ZIKV infection, with severe symptoms and mortality, than 129 Ifnar1 KO mice, which show only mild symptoms. To identify the genes responsible for this difference, I produced and analyzed a backcross between the B6 Ifnar1 KO and 129 Ifnar1 KO strains. Eight significant QTLs and nineteen suggestive QTLs were associated with the viral load, mortality, body weight loss and clinical symptoms of backcross mice.To facilitate genetic analysis of the four crosses analyzed in my PhD project, I have developed stuart, an open-source R package which curates whole-genome genotyping data of second generation crosses produced by arrays for subsequent QTL mapping.My work highlighted the genetic factors involved in the susceptibility to ZIKV infection in these mouse models. Future work will refine these QTL intervals to identify and prioritize candidate genes using a combination of approaches described in this work. Identifying genes underlying these QTLs will provide new insight into the mechanisms of pathogenesis of ZIKV infection. Lastly, as the CC071 strain was recently reported to be susceptible to the infection by other viruses, this strain will be increasingly useful for the study of infectious diseases.L'infection par le virus Zika (ZIKV) chez l'Homme peut provoquer de multiples conséquences, de l'absence de symptômes cliniques à des complications neurologiques ou des microcéphalies après des infections intrautérines. En utilisant le Collaborative Cross (CC), une collection de lignées de souris consanguines avec une large diversité génétique, mon laboratoire a précédemment démontré pour la première fois l'importance de la génétique de l'hôte dans la variabilité clinique de la maladie provoquée par ZIKV, et a identifié CC071 comme la lignée la plus sensible, car elle présentait une forte charge viraledans le sang, des symptômes sévères et de la mortalité.Durant ma thèse, j'ai d'abord étudié l'origine génétique de la sensibilité de la lignée CC071 dans un modèle in vitro. Des fibroblastes embryonnaires de souris (MEFs) de CC071 montraient une forte réplication virale associée à une induction des interférons de type I (IFN-I) retardée. Une analyse de quantitative trait locus (QTL) sur des MEFs dérivés d'un backcross entre CC071 et la lignée résistante CC001 a permis l'identification d'une mutation perte de fonction dans le gène Irf3, spécifique de la lignée CC071. Des analyses fonctionnelles ont montré que cette mutation est entièrement responsable pour le défaut d'induction des IFN-I et la forte réplication virale dans les MEFs de CC071. Cependant, après une infection in vivo par le virus ZIKV, les souris CC071 avaient une plus forte sensibilité que des souris C57BL/6J (B6) Irf3 KO, démontrant que d'autres gènes de sensibilité sont impliqués dans la pathologie des souris CC071 après une infection in vivo.Afin d'identifier ces gènes, j'ai analysé un backcross entre CC071 et B6 Irf3 KO, et une F2 entre CC071 et la lignée 129/SvPas (129) Ifnar1 KO. Leur analyse a permis l'identification de six QTLs significatifs et vingt-trois QTLs suggestifs, associés avec la charge virale, perte de poids, symptômes cliniques et mortalité.J'ai aussi étudié les loci qui modifient la sensibilité à l'infection par ZIKV de souris Ifnar1 KO. Ce KO existe sur deux fonds génétiques, et mon laboratoire a précédemment démontré que les souris de la lignées B6 Ifnar1 KO sont plus sensibles à l'infection par ZIKV, avec des symptômes sévères et de la mortalité, que les souris 129 Ifnar1 KO, qui ne montrent que des symptômes légers. Pour identifier les gènes responsables de cette différence, j'ai produit et analysé un backcross entre les lignées B6 Ifnar1 KO et 129 Ifnar1 KO. HuitQTLs significatifs et dix-neuf QTLs suggestifs ont été associés avec la charge virale, la mortalité, la perte de poids et les symptômes cliniques des souris backcross.Pour faciliter l'analyse des quatre croisements étudiés pendant mon projet de thèse, j'ai développé stuart, un package R en accès libre qui permet la curation des données de génotypage génome-entier de croisements à deux générations produits par puce pour une analyse QTL.Mon travail a permis de mettre en évidence les facteurs génétiques impliqués dans la sensibilité à l'infection par le virus ZIKV chez ces modèles souris. De futures études affineront les intervalles des QTLs pour identifier et prioriser des gènes candidats en utilisant une combinaison d'approches décrites dans cette thèse. L'identification des gènes sous-jacents à ces QTLs apportera de nouvelles connaissances sur les mécanismes de pathogénie de l'infection par ZIKV. Enfin, puisqu'il a été récemment démontré que la lignée CC071 est également sensible à l'infection par d'autres virus, cette lignée sera utile dans le futur pour les études sur les maladies infectieuses
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