58,852 research outputs found
Orchis mascula subsp. hispanica Soo 1972
No full text(e) Subsp.hispanica (A. & C. Nieschalk) Soo, Jahresb. Naturw. Ver. Wuppertal 25: 45 (1972): Spike lax, many-flowered. Perianth-segments obtuse, purple. Lateral lobes of labellum not deflexed; middle lobe slightly longer than the lateral. Spur shorter than to as long as ovary. C. Pyrenees and mountains of S. W. Spain.Published as part of D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press on page 341, DOI: 10.5281/zenodo.21552
Soo-Wang Hyun
No full text학위논문(박사)--아주대학교 일반대학원 :의생명과학과,2015. 2TABLE OF CONTENTS
ABSTRACT i
TABLE OF CONTENTS iii
LIST OF FIGURES vi
ABBREVIATION viii
I. INTRODUCTION 1
II. MATERIALS AND METHODS 4
A. Transient focal cerebral ischemia 4
B. Measurement of brain water content 5
C. Measurement of Evans blue extravasation 5
D. Immunohistochemistry for TJs 5
E. Cell culture 6
F. Endothelial cell monolayer permeability assay 6
G. Immunocytochemistry for TJs and FoxO3a 7
H. Western blot analysis 7
I. Preparation of cell fractions 8
J. Polymerase chain reaction (PCR) 8
K. siRNA transfection 9
L. Measurement of DCF-DA fluorescence 9
M. Preparation of the OE, Quer, YE, and HSP 9
N. Statistical analysis 10
III. RESULTS 11
A. The effects of OE, Quer, YE, and HSP on water content in brain ischemia model 11
B. The effects of OE, Quer, YE, and HSP on Evans blue extravasation in brain ischemia model 14
C. The effects of OE, Quer, YE, and HSP on TJs disruption in brain ischemia model 16
D. The effects of OE, Quer, YE, and HSP on BBB permeability in hypoxia model 18
E. The effects of OE, Quer, YE, and HSP on disruption of ZO-1 and claudin-5 in hypoxia model 22
F. The effects of OE, Quer, YE, and HSP on the expression of MMP-3 and MMP-9 in hypoxia model 26
G. The effects of OE, Quer, YE, and HSP on translocation of FoxO3a into nucleus in hypoxia model 28
H. FoxO3a modulates expression of MMP-3 and MMP-9 in hypoxia model 30
I. FoxO3a affects the degradation of claudin-5 but redistribution of ZO-1 in hypoxia model 32
J. FoxO3a regulates hypoxia-induced BBB hyperpermeability 34
K. The effects of oxidative stress scavengers on hypoxia-induced BBB dysfunction in hypoxia model 36
IV. DISCUSSION 40
V. CONCLUSION 46
VI. REFERENCES 47
국문요약 52DoctoralThis study investigated the potential beneficial effects of natural products and their major component on redistribution of ZO-1 and FoxO3a-mediated degradation of claudin-5 during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses.
Onion extract (OE) and its major component, quercetin (Quer), as well as yuzu extract (YE) and hesperidin (HSP) prevented brain ischemia-induced brain edema in dose-dependent manners. Evans blue extravasation in the ischemic hemisphere of the mouse brain was also significantly reduced by treatment with the four materials. In addition, they inhibited the immunoreactivity of tight junction proteins (TJs; ZO-1 (Zonula occludens-1) and claudin-5).
In in vitro model, pre-treatment of OE, Quer, YE, and HSP significantly attenuated hypoxia-induced Blood-Brain Barrier (BBB) hyperpermeability. The four materials also inhibited hypoxia-induced redistribution of ZO-1, degradation of claudin-5, increase of matrix metalloproteinase (MMP)-3/9 mRNA levels, and translocation of Forkhead box O 3a (FoxO3a) into nucleus. The effects of antioxidant, trolox, and N-acetyl-cysteine (NAC) as well as siFoxO3a transfection also mimicked those effects of OE, Quer, YE, and HSP. However, transfection of siFoxO3a did not inhibit transcription of MMP-9 and redistribution of ZO-1 induced by hypoxia. In addition, OE, Quer, YE, and HSP attenuated the generation of oxidative stress induced by hypoxia, indicating that they may have antioxidant effects against hypoxia induced-dysfunction of BBB.
The results from this study demonstrate that OE, Quer, YE, and HSP prevent BBB hyperpermeability and tight junction proteins (TJs) disruption in MCAO and hypoxia model. In addition, these findings suggest that BBB protection by the four materials involves reduction of MMPs transcription, the inhibition of ZO-1 redistribution, and FoxO3a inhibition-mediated suppression of claudin-5 degradation, possibly through its antioxidant effects in hypoxia model
Ophrys sphegodes subsp. tommasinii (Vis.) Soo 1970
No full text<p>(c) Subsp.tommasinii (Vis.) Soo,</p> <p>Acta Bot. Acad. Sei. Hung. 16: 382 (1970) (O.tommasinii Vis.):</p> <p>Flowers usually 3-5, rarely more. Inner perianth-segments 3-veined. Labellum 6-10x6-10 mm, with basal protuberances, pale brown, papillose-subvillous; speculum U-shaped, scutelliform, glabrous.</p> <p>• Coasts of W. Jugoslavia and N. W. Greece.</p>Published as part of <i>D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press</i> on page 346, DOI: <a href="http://zenodo.org/record/215522">10.5281/zenodo.215522</a>
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
DEVELOPMENT OF SYNTHETIC SPECIMENS FOR CALIBRATION AND EVALUATION OF M SUB R (RESILIENT MODULUS) EQUIPMENT
No full textLaboratory measurement of the deformational characteristics of subgrade materials can be quite difficult because of the small values of stress and strain typically involved and the need to eliminate equipment compliance. Measurement of resilient modulus (M sub R) of subgrades falls into this category. Therefore, synthetic specimens with known stiffness characteristics would be beneficial in evaluating and calibrating M sub R equipment as well as training personnel. Two-component urethane elastomer resins are shown to make good candidates for calibration specimens. They can be made with a wide range of stiffnesses that vary from soft subgrades to stiff uncemented bases. Urethane can be modeled as a linear, viscoelastic material with stiffness characteristics essentially independent of confining pressure, strain amplitude, and stress history for the type of cyclic loading used in M sub R testing. Urethane stiffness is, however, dependent on loading frequency and temperature. Therefore, values of Youngs modulus used to equate to M sub R have to be selected at the appropriate frequency and temperature
Dactylorhiza majalis subsp. praetermissa (Druce) D. Moresby Moore & Soo 1978
No full text<p>(e) Subsp.praetermissa (Druce) D. Moresby Moore & Soö,</p> <p>loc. cit. (1978) (Orchispraetermissa Druce):</p> <p>Stem up to 75 cm. Lower leaves lanceolate, widest below middle, without spots. Flowers pale or dull reddish-purple. Labellum 10-14 mm, shallowly and equally 3-lobed, with a central cluster of small spots. 2n=80.</p> <p>• N. W. Europe.</p>Published as part of <i>D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press</i> on page 335, DOI: <a href="http://zenodo.org/record/215522">10.5281/zenodo.215522</a>
Dactylorhiza cordigera subsp. siculorum (Soo) Soo 1962
No full text<p>(c) Subsp.siculorum (Soö) Soö,</p> <p>loc. cit. (1962):</p> <p>Inner perianth- segments obliquely lanceolate. Labellum suborbicular, entire to deeply 3-lobed. Spur 8-11 mm, conical-cylindrical, up to £ as long as ovary.</p> <p>• Romania and W. Ukraine.</p>Published as part of <i>D. M. Moore (ed.), 1980, CCIII Orchidaceae, pp. 325-350 in Flora Europaea, Vol 5: Alismataceae to Orchidaceae, Camebridge :Cambridge University Press</i> on page 335, DOI: <a href="http://zenodo.org/record/215522">10.5281/zenodo.215522</a>
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
PROTOTYPE DESIGN AND EVALUATION OF AN FSAE-BASED PURE ELECTRIC VEHICLE WITH WIRELESS CHARGING TECHNOLOGY
No full textWith growing concern of environment and limited petroleum, eco-friendly vehicle systems such as hybrid, plug-in hybrid and pure electric vehicle are introduced to the market globally. While the technological limitations on pure electric vehicles, such as lesser than customer expected driving range due to the limited power and energy capacity of the on-board energy storage device, and the developing phase of charging infrastructure, are still exist, the automotive industry and its stakeholders are paying significant attention to the electric vehicle technology. On the other hand, in the car racing, there are strong movement to introduce electric vehicles in racing automotive industry. Electrifying Formula One is a good example in this regard. Various emerging college-level competitions on hybrid, plug-in hybrid, solar and electric vehicle racings are also important activities in view of massive and prompt penetration to the market and technological development in efficiency, durability and system integration. In this paper, we would like to present a FSAE (Formula SAE)-based pure electric vehicle with the wireless charging technology, called OLEV. This charging technology can be applied not only to the static wireless charging but also the on-road dynamic charging, which means vehicle's on-board battery can be charged while the vehicle is running on the road with installed power supply system. This paper introduces and emphasizes the unique architecture of FASE-based vehicle specification, but modified to have pure electric drive and battery system, in addition to the dynamic wireless charging system on-board. This vehicle is the only kind in the world on FSAE-platform of on-road dynamic charging electric vehicle. We discuss the design, packaging and simulated performance of the vehicle, in addition to the proper 110V DC power supply and flow management approach, which are unique contributions of this paper.
Exclusive and inclusive semileptonic decays of B mesons to D mesons
No full textcomplete author list: Fulton R.; Jensen T.; Johnson D.; Kagan H.; Kass R.; Morrow F.; Whitmore J.; Wilson P.; Bortoletto D.; Chen W.; Dominick J.; McIlwain R.; Miller D.; Ng C.; Schaffner S.; Shibata E.; Shipsey I.; Yao W.; Battle M.; Sparks K.; Thorndike E.; Wang C.; Alam M.; Kim I.; Li W.; Romero V.; Sun C.; Wang P.; Zoeller M.; Goldberg M.; Haupt T.; Horwitz N.; Jain V.; Mestayer M.; Moneti G.; Rozen Y.; Rubin P.; Sharma V.; Skwarnicki T.; Thulasidas M.; Zhu G.; Csorna S.; Letson T.; Alexander J.; Artuso M.; Bebek C.; Berkelman K.; Browder T.; Cassel D.; Cheu E.; Coffman D.; Crawford G.; Dewire J.; Drell P.; Ehrlich R.; Galik R.; Garcia-Sciveres M.; Geiser B.; Gittelman B.; Gray S.; Halling A.; Hartill D.; Heltsley B.; Honscheid K.; Kandaswamy J.; Katayama N.; Kreinick D.; Lewis J.; Ludwig G.; Masui J.; Mevissen J.; Mistry N.; Nandi S.; Nordberg E.; O'Grady C.; Peterson D.; Pisharody M.; Riley D.; Sapper M.; Selen M.; Silverman A.; Stone S.; Worden H.; Worris M.; Sadoff A.; Avery P.; Besson D.; Garren L.; Yelton J.; Kinoshita K.; Pipkin F.; Procario M.; Wilson R.; Wolinski J.; Xiao D.; Zhu Y.; Ammar R.; Baringer P.; Coppage D.; Davis R.; Haas P.; Kwak N.; Lam H.; Ro S.; Kubota Y.; Nelson J.; Perticone D.; Poling R.; Fulton R.; Poling R.; Perticone D.; Nelson J.; Fulton R.</p
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