15 research outputs found
Axisymmetric deformation in a micropolar thermoelastic medium under fractional order theory of thermoelasticity
No full textQuantum chemical investigations on the molecular structure, FTIR, UV-Vis and HOMO-LUMO analysis of 15-16-epoxy-7b, 9a dihydroxylabdane 13(16), 14-dien-6-one
No full textRetracted Article: Addiction of drugs like Cocaine and Opium - A Review
No full textThis paper has been formally retracted on ethical grounds because the article contains instances of plagiarism, without proper citation. The authors are responsible for this mistake and apologise for it. Request approved by the proceedings Editor and the Publisher on December 10, 2021
Pathological study of non-neoplastic urinary bladder lesions in cattle and buffaloes: a preliminary report
No full textNUCLEAR QUADRUPOLE RESONANCE ZEEMAN STUDY OF
No full textAuthor Institution: Department of Chemistry, Virginia Polytechnic Institute and State UniversityThe Zeeman splittings of the nuclear quadrupole resonance transition at 16.303 MHz in a single crystal of barium chloride dihydrate, has been studied and the zero-splitting loci for both physically non-equivalent lattice sites have been determined. From the study it was found that the nuclear quadrupole coupling constant is = 29.8 MHz and that the asymmetry parameter is . The direction of the electric field gradient (EFG) principal axis system relative to the crystal axis system was found. The magnitudes and directions of the EFG tensor components were calculated by using a point charge-point dipole model and isotropic polarizabilities. By using a projected Sternheimer factor of -80 this leads to a calculated coupling constant of 60 MHz and an asymmetry parameter of 0.1. Both the experimental and calculated values of the parameters are in agreement with the crystal symmetry. In view of the simplifications inherent in the model used this represents reasonable agreement
Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress
No full textAcknowledgments We thank Alexander Johnson (yhb1D/D), Karl Kuchler (sodD/D mutants), Janet Quinn (hog1D/D, hog1/cap1D/D, trx1D/D) and Peter Staib (ssu1D/D) for providing mutant strains. We acknowledge helpful discussions with our colleagues from the Microbial Pathogenicity Mechanisms Department, Fungal Septomics and the Microbial Biochemistry and Physiology Research Group at the Hans Kno¨ll Institute (HKI), specially Ilse D. Jacobsen, Duncan Wilson, Sascha Brunke, Lydia Kasper, Franziska Gerwien, Sea´na Duggan, Katrin Haupt, Kerstin Hu¨nniger, and Matthias Brock, as well as from our partners in the FINSysB Network. Author Contributions Conceived and designed the experiments: PM HW IMB AJPB OK BH. Performed the experiments: PM CD HW. Analyzed the data: PM HW IMB AJPB OK BH. Wrote the paper: PM HW OK AJPB BH.Peer reviewe
Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
No full textSummary: Clinical and molecular evidence indicates that high-grade serous ovarian cancer (HGSOC) primarily originates from the fallopian tube, not the ovarian surface. However, the reasons for this preference remain unclear. Our study highlights significant differences between fallopian tube epithelial (FTE) and ovarian surface epithelial (OSE) cells, providing the molecular basis for FTEs as site of origin of HGSOC. FTEs, unlike OSEs, exhibit heightened replication stress (RS), impaired repair of stalled forks, ineffective G2/M checkpoint, and increased tumorigenicity. BRCA1 heterozygosity exacerbates these defects, resulting in RS suppression haploinsufficiency and an aggressive tumor phenotype. Examination of human and mouse sections reveals buildup of the RS marker 53BP1 primarily in the fallopian tubes, particularly at the fimbrial ends. Furthermore, menopausal status influences RS levels. Our study provides a mechanistic rationale for FTE as the site of origin for HGSOC, investigates the impact of BRCA1 heterozygosity, and lays the groundwork for targeting early HGSOC drivers
Abstract PR04: The genomic architecture of serous carcinomas shapes the tumor microenvironment and modulates responses to targeted and immunotherapies
No full textAbstract A29: The genomic architecture of serous carcinomas shapes the tumor microenvironment and modulates responses to targeted and immunotherapies
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