139 research outputs found
Comparisons of treatment strategies for necrotizing pancreatitis
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2010. 2ABSTRACT =ⅰ
TABLES OF CONTENTS = iii
LIST OF FIGURES = iv
LIST OF TABLES = v
Ⅰ. INTRODUCTION = 1
Ⅱ. MATERIALS AND METHODS = 4
A. MATERIALS = 4
B. DIAGNOSTIC METHODS = 5
C. OUTCOME MEASUREMENTS = 5
D. STATISTICAL ANALYSIS = 6
Ⅲ. RESULTS = 7
Ⅳ. DISCUSSION = 14
Ⅴ. CONCLUSION = 19
REFERENCES = 20
국문요약 = 24MasterForty to seventy percent of secondary bacterial infections, mainly by Gram-negative organisms, can be combined with necrotizing pancreatitis, and it's mortality with organ failure is reported to be nearly 30%. Specific symptoms, contrast-enhanced abdominal computed tomography(CECT), Ranson's score, APACHE II score and confirmed infected necrosis by fine needle aspiration can be helpful for identifying diagnosis and disease severity. There have been controversies about conservative or operative treatment for necrotizing pancreatitis and surgical indications. Many studies in the literatures have shown infected necrosis as a definite surgical indication, similar to combined bowel perforation or massive uncontrolled intraabdominal hemorrhage.
In this retrospective report, 37 hospitalized patients who were diagnosed with necrotizing pancreatitis during the past 13 years were analyzed for therapeutic strategies, clinical course and results. Etiology and basic hemodynamic parameters, including pancreatic enzymes, CT severity index(CTSI), Ranson's score and APACHE II score, were analyzed. The incidence of pancreatic pseudocyst, pleural effusion, abdominal percutaneous lavage drainage, infected necrosis, organ failure and mortality rate, total hospital stay, the number of admission and length of stay in intensive care unit(ICU) were also identified.
All patients were routinely treated with prophylactic antibiotics, while 13 out of 37 patients were treated surgically. The etiologies included biliary(12), alcoholic(16) and others(9) such as postoperative, trauma and idiopathic. The rate of confirmed infected necrosis was 85.7%(6/7) in conservative treatment group and 100%(12/12) in surgical treatment group, showing significantly different etiology(p=0.001) between the two groups, and Ranson's score(p=0.025), APACHE II score(p=0.028), and total hospital stay(p=0.045), length of stay in ICU(p=0.019) were significantly higher in surgical treatment group. The mortality rates did not show any difference between the two groups(p=1.000). The timing of operation which was set up by 3 weeks resulted in no differences in clinical course and outcomes. There were also no differences between the two groups in clinical course and results in case of high Ranson's and APACHE II score, except the relation of high APACHE II score and length of stay in ICU(p=0.002).
This study showed that infected necrosis could not be surgical indication for necrotizing pancreatitis, because 6 patients fully recovered from the disease by only conservative treatment. Patients who were conservatively treated showed better clinical course and outcomes. Furthermore, Ranson's score or APACHE II score were not useful for deciding treatment strategy for necrotizing pancreatitis. Conservative treatment and cautious surgical observation should sincerely be considered for treatment of necrotizing pancreatitis
sj-docx-1-tar-10.1177_17534666231162244 – Supplemental material for A prospective study on the long-term storage of sputum and the recovery of nontuberculous mycobacteria
No full textSupplemental material, sj-docx-1-tar-10.1177_17534666231162244 for A prospective study on the long-term storage of sputum and the recovery of nontuberculous mycobacteria by Byoung Soo Kwon, Jeong Su Park, Jung-A Shin, Eun Sun Kim, Sung Yoon Lim, Myung Jin Song, Yeon-Wook Kim, Hyung-Jun Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Yoon, Choon-Taek Lee and Jae Ho Lee in Therapeutic Advances in Respiratory Disease</p
Drug-induced hepatotoxicity of anti-tuberculosis drugs and their serum levels
No full textThe correlation between serum anti-tuberculosis (TB) drug levels and the drug-induced hepatotoxicity (DIH) remains unclear. The purpose of this study was to investigate whether anti-TB DIH is associated with basal serum drug levels. Serum peak levels of isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) were analyzed in blood samples 2 hr after the administration of anti-TB medication. Anti-TB DIH and mild liver function test abnormality were diagnosed on the basis of laboratory and clinical criteria. Serum anti-TB drug levels and other clinical factors were compared between the hepatotoxicity and non-hepatotoxicity groups. A total of 195 TB patients were included in the study, and the data were analyzed retrospectively. Seventeen (8.7%) of the 195 patients showed hepatotoxicity, and the mean aspartate aminotransferase/alanine aminotransferase levels in the hepatotoxicity group were 249/249 IU/L, respectively. Among the 17 patients with hepatotoxicity, 12 showed anti-TB DIH. Ten patients showed PZA-related hepatotoxicity and 2 showed INH- or RMP-related hepatotoxicity. However, intergroup differences in the serum levels of the 4 anti-TB drugs were not statistically significant. Basal serum drug concentration was not associated with the risk anti-TB DIH in patients being treated with the currently recommended doses of first-line anti-TB treatment drugs.Y
The clinical significance of CA-125 in pulmonary tuberculosis
No full textCancer antigen 125 (CA-125) is usually elevated in ovarian cancer. However, there are several reports that serum CA-125 is elevated in tuberculosis. This study investigated the clinical significance of serum CA-125 measurements in patients with active pulmonary tuberculosis (TB). Between September 2008 and March 2011, Serum CA-125 was measured in patients with active pulmonary TB before treatment (baseline), and 6 and 12 months after initiation of anti-TB treatment. Patients with pulmonary TB confirmed by culture or polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) were included. The study enrolled 100 patients. The mean serum CA-125 was 38.9 +/- 41.4 U/ml (reference value, <35 U/ml). Thirty-eight patients showed elevated CA-125. Significantly more of those with elevated CA-125 were female (p < 0.001), and had a positive sputum smear for acid-fast bacilli (AFB) (p = 0.030). They also significantly more showed extensive pulmonary lesions on chest X-ray (p = 0.004). Elevated CA-125 was independently associated with female gender (OR = 12.5, 95% CI: 3.4-45.2), positive acid-fast staining of sputum (OR = 6.0, 95% CI: 1.8-19.7), cavitary lung lesion (OR = 4.0, 95% CI: 1.2-12.9), and involvement of more than one lung on chest X-ray (OR = 9.4, 95% CI: 2.2-40.1). The CA-125 level decreased with anti-TB treatment (p = 0.001). Serum CA-125 was related to the activity and severity of pulmonary TB, and it may be useful in the monitoring of therapeutic responses in certain cases of active pulmonary TB, especially in female patients of active pulmonary TB. (C) 2013 Elsevier Ltd. All rights reserved.N
Low serum 25-hydroxyvitamin D level: An independent risk factor for tuberculosis?
No full textBackground & aims: Vitamin D deficiency has been associated with an increased risk of tuberculosis (TB). Low serum vitamin D levels may also be associated with poor nutritional status in TB patients. Therefore, this study aimed at evaluating the association between low serum vitamin D level and TB, regardless of other nutritional factors. Methods: Baseline serum 25-hydroxyvitamin D (25(OH)D3) levels in TB patients were measured before treatment and 1 year after treatment onset using liquid chromatography tandem mass spectrometry, and were compared with 25(OH)D3 levels in controls. Nutritional parameters were also measured in all subjects. Results: In total, 165 active pulmonary TB patients and 197 controls were included in the study. Significantly higher prevalence of 25(OH)D3 insufficiency (<20 ng/mL) and deficiency (<10 ng/mL) in TB patients was showed compared to controls. Serum 25(OH)D3 levels and nutritional parameters were significantly lower in untreated TB patients than in controls. One year after TB treatment onset, nutritional parameters significantly increased; however, serum 25(OH)D3 levels in TB patients showed no significant improvement compared to baseline. Conclusions: These results suggest that a low serum 25(OH)D3 level might be a risk factor for TB, independent of nutritional status. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.N
A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease
No full textResearch on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD
Population pharmacokinetics of moxifloxacin, cycloserine, p -aminosalicylic acid and kanamycin for the treatment of multi-drug-resistant tuberculosis
No full textControl of multi-drug-resistant tuberculosis (MDR-TB) requires extensive, supervised chemotherapy because second-line anti-TB drugs have a narrower therapeutic range than first-line drugs. This study aimed to develop population pharmacokinetic (PK) models for second-line drugs in patients with MDR-TB, evaluate the recommended dosage regimens and, if necessary, suggest new dosage regimens. A prospective, single-centre PK study was performed on second-line anti-TB drugs in patients with MDR-TB. Moxifloxacin, cycloserine, p-aminosalicylic acid (PAS), kanamycin and other second-line drugs were administered to the patients. Plasma concentrations were analysed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Population PK models were developed using non-linear mixed effect modelling (NONMEM, Version 7.30; ICON Development Solutions, Ellicott City, MD, USA). Simulations were performed using the calculated PK parameters. The respective absorption rate constant, apparent clearance and apparent volume of distribution values were as follows: 0.305/h, 9.37 L/h and 56.7 L for moxifloxacin; 0.135/h, 1.38 L/h and 10.5 L for cycloserine; 0.510/h, 30.8 L/h and 79.4 L for PAS; and 1.67/h, 3.75 L/h and 15.2 L for kanamycin. The simulations showed that the following dosage regimens were more likely to be within the recommended concentration ranges than the raw data in this study: 200 mg of moxifloxacin once daily (QD) (patient weight <50 kg) and 400 mg of moxifloxacin QD (patient weight >= 50 kg), 500-750 mg of cycloserine QD, 4.95-6.6 g of PAS twice daily and 750-1000 mg of intramuscular kanamycin QD. These findings indicate that the recommended doses should be revised to improve the clinical outcomes of MDR-TB treatment. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.N
Incidence of preventable cardiopulmonary arrest in a mature part-time rapid response system: A prospective cohort study
No full text© 2022 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background The purpose of a rapid response system (RRS) is to reduce the incidence of preventable cardiopulmonary arrests (CPAs) and patient deterioration in general wards. The objective of this study is to investigate the incidence and temporal trends of preventable CPAs and determine factors associated with preventable CPAs in a hospital with a mature RRS. Methods This was a single-center prospective cohort study of all CPAs occurring in the general ward between March 2017 and June 2020. The RRS operates from 07:00 to 23:00 on weekdays and from 07:00 to 12:00 on Saturdays. All CPAs were reviewed upon biweekly conference, and a panel of intensivists judged their preventability. Trends of preventable CPAs were analyzed using Poisson regression models and factors associated with preventable CPAs were analyzed using multivariable logistic regression. Results There were 253 CPAs over 40 months, and 64 (25.3%) of these were preventable. The incidence rate of CPAs was 1.07 per 1000 admissions and that of preventable CPAs was 0.27 per 1000 admissions. The number of preventable CPAs decreased by 24% each year (incidence rate ratio = 0.76; p = 0.039) without a change in the total CPA incidence. The most common contributor to the preventability was delayed response from physicians (n = 41, 64.1%). A predictable CPA with a pre-alarm sign had increased odds in the occurrence of preventable CPAs, while a cardiac cause of CPAs and RRS operating hours had decreased odds in terms of occurrence of preventable CPA. Conclusion Our study showed that one-fourth of all CPAs occurring in the general wards were preventable, and these arrests decreased each year. A mature RRS can evolve to reduce preventable CPAs with regular self-evaluation. Efforts should be directed at improving physicians response time since a delay in their response was the most common cause of preventable CPAs.Y
(A) STUDY ON THE COMPARISON OF CHOON-AENG JUN : in Korea and in Japan
No full textThe purpose of this study is to contribute to the understandng of one of the traditional Korea dance forms, Choon-Aeng Jun, by comparing it to the Japanese dance of the same name. At present there is no thorough comparative analyies. Both of these Japanese and Korean Choon-Aeng Jun are representative of royal court music but other creteria such as music, costume, structure, and dancers and compared for similarities and differences.
Firstly, to take a look at the development of Japanese dance music, there are Japan&apos;s indigenous national dance music and three-country music as well as imported dance such as Tang music, Lim-Eup music, Tagla music, and Balhae music. Among them, the indigenous dance music gradually lost its popular characteristics and acquired aristooratic elements.
It was when A-Ak-Ryo, a dance educational organization, was established that Japanese dance music confirmed its system. Since then, imported dance music, which had formerly been an imitation, proved it self as Japanese own art.
The most conspicuous characteristic of this reform was the adoption of Left-Right Dual System, which resulted in the succession of dancers along family lines.
In addition, dance music was protected by A-Ak-So during the age of Tokugawa, and A-Ak-Guk was instituted after the Meiji Era, which was succeeded by Gung-Nae-Sung A-Ak-Bu and Gung-Nae-Chung-Ak-BU.
Generally, dance music is divided into four categories; ordinary dance, martial dance, Ju-Mul, and children&apos;s dance. Choon-Aeng Jun, which is usually performed by 4-5 people, belongs to the first category. As a rule, dance music is performed by a group composed of left dancers and right dancers. Left dancers&apos; dance is evidently different from that of the right dancers in arrangement of musical instruments, and costumes.
The components of dance music are stage, dancing hall, dancing mask, and musical notes.
It is said that Japanese Choon-Aeng Jun was introduced from The author can China, but it is not based on a reliable record. The author can only guess that it was brought in by Japanese envoys around 6-7 centuries when dance music was also imported.
Besides, Japanese Choon-Aeng Jun is performed by a single dancer, and it can be compared to a cantata composed of various vocal and dancing techniques of one person.
Music and costumes of Japanese Choon-Aeng Jun are very similar to China in Tang Era. In Japanese Choon-Aeng Jun, a costume called Tang-Jang Sok is frequently worn, and this implies that Japanese Choon-Aeng Jun is one of the Left dances in Tang music system.
Yet, though Korean Choon-Aeng Jun is similar to the Japanese one in its name and in that it was originated from an order of a Chinese emperor who commanded his musicians to describe song of a nightingale, it is different from the Japanese one in tha t it was first performed in the age of the 28 king of Cho-sun when the prince Hyo-Myung celebrated the birthday of queen Sook by composing music.
In its content and process, Korean Choon-Aeng Jun is interesting in that it can show individual beauty and artistic sense because it is performed by only one dancer, and in that the names of dancing techniques are clearly described.
The costumes and music of Korean Choon-Aeng Jun is quite different from those of Japanese, because the Korean one borrowed only the name from China, receiving the mode and form of traditional royal court dance of Korea.
To conclude, if we compare Japanese Choon-Aeng Jun with that of Korea,
First, though the names are identical, the structures are distinct.
Second, Korean Choon-Aeng Jun borrowed only its name from China while t h e Japanese sent envoys to China to learn it directly*
Third, Korean Choon-Aeng Jun was first performed in the era of king Soon-Jo, while it was when the emperor Mun-Mu or emperor In-Myung was on the throne for the Japanese.
Fourth, in Korea, dancers are composed of only one person, a child or a dancing girl, while in Japan there are 4-6 men.
Fifth, Korean Choon-Aeng Jun is performed on a mat from the beginning to the end, but the Japanese one is performed by one person after another in a dancing hall.
Sixth, the musical key is different between Korean Choon- Aeng Jun and the Japanese one.
Through the above comparative analysis, we came to know that Japanese Choon-Aeng Jun and Korean Choon-Aeng Jun were formed distinctly, affected by each country&apos;s tradition and culture as well as life style.
Lastly, we ought to take pride in the fact that Japanese dance music was largely influenced by Shilla, Baekje, Kokuryo and Balhae which existed on the Korean peninsula, and do our best to preserve and cherish Korean dance.;本稿는 우리나라 傳統舞踊중 궁중무용의 鄕樂呈才 양식인 春鶯전에 대하여 그 내용과 형식 및 제반요소들을 日本舞樂 춘앵전과 비교 분석함으로써 50여종 밖에 남아있지 않은 呈才의 保存 繼承에 그 意義를 두었고, 지금까지 韓國의 춘앵전과 비교 고찰한 日本 춘앵전의 &apos;本格的인 硏究가 이루어지지 않았다는 점을 중시하여 이에 관한 학문적 체계를 정립하는데 보탬이 되고자 한다.
먼저 日本 舞樂의 發展過程을 살펴보면, 예로부터 傳承되어 온 日本 獨自的인 國風舞와 三國樂(三韓樂) ,唐樂 林邑樂, 度羅樂, 渤海樂 등의 外來舞가 있는데, 日本의 舞樂은 점차적으로 外來舞의 영량을 받아 본래의 民衆藝能的인 색채를 잃고 貴族藝能的 性質로 변해 왔다.
日本舞樂이 體系를 確立한 때는 최초의 舞樂敎育機關인 「雅樂寮」(701年)가 設立되고부터인데, 당초 模倣的인 上演에 그쳤던 外來舞樂이 日本의 藝能으로서 소화·흡수되어 日本化되어 갔다.
이를 추진한 改革의 最大特徵은 「左右 兩部制」의 確立이며, 이에 따른 舞人의 固定化는 世襲化는 日本舞樂의 血統主義를 탄생시켰다.
또한 德川幕府 때는「雅樂所」가 設置되면서 舞樂이 保護되었고, 明治(1868∼1912)以後에는 「雅樂局」이 設置되었으며 이것이 後에는 「宮內省 雅樂部」「官內廳樂部」로서 계승되고 있다.
舞樂은 보통 文舞(平舞), 武舞, 走物, 童舞라는 4가지로 分類되는데, 춘앵전은 4∼6人이 춤추는 文舞에 포함된다. 그리고 舞樂을 上演하는데 있어서 左右舞와 右方舞가 한 組를 이루어 춤추는데, 그 반주악기의 편성, 의상 등에 있어서 左方舞와 右方舞는 양식상의 明白한 차이가 있다.
舞樂의 構成要素로는 舞臺, 樂室, 舞樂탈과 그 외 小道具 그리고 舞譜가 있다.
이러한 日本舞樂에 따른 日本의 춘앵전은 中國에서 傳來되었다고 하지만 口傳일 뿐 記錄이 확실치 않다. 다만 본 연구자의 見解로는 舞樂의 輸入時期인 6C ∼ 9C 사이 文武天皇(697 ∼ 707)때 遺唐使들에 의해 流入됐을 것이라고 추측한다.
또한 日本의 춘앵전은 그 節次에 있어서 기본적으로 遊聲·序·颯踏·入破·島聲·急聲으로 構成되는 일종의 組曲이며, 그 前後에 調子 및 入調 등 8개의 部分으로 되어 있다.
日本 춘앵전의 音樂은 唐樂의 樂曲과 매우 흡사하며, 服飾은 唐裝束 또는 常裝束이라고도 불리우는 襲裝束을 빈번히 着用한다. 이는 日本 춘앵전이 唐樂系의 左方舞의 하나라는 特徵을 說明해 주기도 한다.
韓國의 춘앵전은 B.C 7세기경 唐나라 高宗이 어느 봄 새벽에 괴꼬리 울음소리에 감동해서 樂土에게 이를 묘사하여 짓게 한 曲이 춘앵전 이라는 由來와 名稱은 日本 춘앵전과 같다.
그러나 시기적으로 朝鮮 純祖 28年때 孝明世子가 純元肅皇后의 보령 40을 경축하기 위하여 樂章을 지었고, 이를 예조에서 받아들여 金昌河 典樂에게 呈才를 지어 올리게 하였으며. 이때 처음 上演되었다.
內容 및 節次에 있어서 혼자 獨舞하기 때문에 個人의 美와 藝術性을 확보하며, 춤사위의 名稱이 분명하고 아름답게 묘사되어 있다는 점이 이채롭다.
音樂과 服飾은 日本 舞樂 춘앵전과 매우 다른데, 이는 韓國의 춘앵전이 명칭만 빌었을 뿐, 그 외의 것은 우리나라 궁중정재의 양식과 형태를 전수받고 있기 때문이다.
이에 日本 舞樂 춘앵전과 韓國 춘앵전을 비교 분석하면,
첫째, 명칭은 同一하나 舞樂과 呈才라는 構造 자체가 다르다.
둘째, 전승경로가 韓國 춘앵전은 명칭만을 중국에서 빌어 왔는데, 日本은 遺唐使를 중국에 보내 직접 배워왔다.
셋째, 연대가 韓國 춘앵전은 朝鮮 純祖 28年이지만 日本은 文武天皇 (697 ∼ 707)說과 仁明天皇(833 ∼ 850)說이 유력시 된다.
넷째, 무용수가 韓國 춘앵전은 舞童이나 女妓 1명인데, 日本은 女子에서 男子가 추는 것으로 변모되어 4명 내지 5명이 동원된다.
다섯째, 형태면에 있어서 韓國 춘앵전은 처음부터 화문석 위에 서서 시작하여 화문석에서 끝내지만, 日本은 樂室에 한 사람씩 등장하여 한 사람씩 퇴장하여 끝낸다.
여섯째, 音樂은 韓國에서는 平調靈山會相曲을 사용하나 日本에서는 壹越調이다.
이상과 같은 비교분석을 통해 日本 舞樂 춘앵전과 韓國 춘앵전은 각기 독자적인 것으로 각 나라의 전통문화와 생활습관에 접목되어 그 특색에 맞는 독특한 춤이 이루어졌음을 알게 된다.
다만 日本 舞樂이 신라·백제·고구려·발해 舞樂의 영향에 의해 형성되었다는 점에서 韓國舞踊의 자긍심과 함께 이를 後世에 계승하고 保傳하는 문제는 시급하다고 생각한다.목차 = ⅲ
論文槪要 = ⅴ
Ⅰ. 序論 = 1
A. 硏究目的 = 1
B. 硏究方法 = 2
Ⅱ. 日本 舞樂에 關한 槪觀 = 3
A. 發展過程 = 3
B. 分類 및 特徵 = 11
C. 構成要素 = 20
Ⅲ. 日本舞樂 춘앵전에 대한 背景 = 30
A. 歷史的 背景 = 30
B. 內容 및 節次 = 32
C. 音樂·舞譜 및 服飾 = 41
Ⅳ. 韓國 춘앵전에 關한 背景 = 59
A. 歷史的 背景 = 59
B. 內容 및 節次 = 60
C. 音樂·춤사위 풀이 = 64
Ⅴ. 兩國 춘앵전의 比較 = 72
Ⅵ. 結論 = 74
參考文獻 = 77
附錄 = 79
ABSTRACT = 9
Comparison of the Sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB According to Patient Age.
No full textCurrently, there are two types of interferon-gamma release assays (IGRAs) in use for the detection of tuberculosis (TB) infection, the QuantiFERON-TB Gold In-Tube test (GFT-GIT) and T-SPOT.TB. Owing to contradictory reports regarding whether the results of these IGRAs are affected by the age of the patient, we aimed to determine if these two tests have age-related differences in sensitivity. We retrospectively reviewed the medical records of diagnosed TB patients who were tested using either QFT-GIT or T-SPOT.TB from February 2008 to December 2013. The positivity of the two tests was analyzed and compared with true TB infection, which was defined as active TB based on either a positive Mycobacterium culture or a positive TB polymerase chain reaction. The QFT-GIT group included 192 TB patients, and the T-SPOT.TB group included 212 TB patients. Of the patients with pulmonary TB, 76 (39.6%) were in the QFT-GIT group and 143 (67.5%) in the T-SPOT.TB group. The overall sensitivity was 80.2% for QFT-GIT and 91.0% for T.SPOT.TB. The sensitivities of QFT-GIT and T-SPOT.TB according to age group were as follows: 70 years, 68.3% and 85.7%, respectively. The trend of age-related changes in sensitivity was significant for both QFT-GIT (p = 0.004) and T.SPOT.TB (p = 0.039). However, only QFT-GIT was significantly related to age in the multivariate analysis. QFT-GIT, but not T-SPOT.TB, was significantly affected by patient age
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