62,973 research outputs found
Management of Unruptured AVMs: The Pendulum Swings
No full textThe ARUBA study is a multi-institutional randomized controlled trial that compared the risk of death and
symptomatic stroke in patients with unruptured AVMs.
Patients were randomized in a 1:1 ratio to medical management versus interventional therapy plus medical management. The intervention given to the patient (surgical removal,
embolization, stereotactic radiosurgery [SRS], or a combination of these) was left to the discretion of the individual
practitioners. The study was closed to accrual early when it
reached prespecified stopping rules, with results suggesting
the superiority of the medical management group. At that
time, 114 patients were assigned to interventional therapy and
109 to medical management. The risk of death or stroke was
significantly lower in the medical management group than in
the interventional group (hazard ratio, 0.27; P < .0001)
sj-pdf-1-dst-10.1177_19322968211059537 – Supplemental material for Diabetes Device Downloading: Benefits and Barriers Among Youth With Type 1 Diabetes
No full textSupplemental material, sj-pdf-1-dst-10.1177_19322968211059537 for Diabetes Device Downloading: Benefits and Barriers Among Youth With Type 1 Diabetes by Benjamin A. Palmer, Karissa Soltys, M. Bridget Zimmerman, Andrew W. Norris, Eva Tsalikian, Michael J. Tansey and Catherina T. Pinnaro in Journal of Diabetes Science and Technology</p
Stereotactic Radiosurgery for Resected Brain Metastases: New Evidence Supports a Practice Shift, but Questions Remain
No full textBrain metastases are a common and devastating complication of cancer. Surgical resection of brain metastases remains an important treatment modality, especially for larger lesions with symptomatic mass effect. However, recurrence in the surgical bed occurs in approximately 60% of cases following resection alone
Treatment of Gliomas: A Changing Landscape
No full textIn the past, the Central Nervous System Editors have examined changes in radiation oncology and they continue their efforts in this Oncology Scan on gliomas. For many years, surgery and radiation therapy have played a significant role in the treatment of patients with glioma.
Chemotherapy was shown to provide a survival benefit when added to radiation therapy for patients with glioblastoma in 2005 and anaplastic oligodendroglioma in 2013. In the past decade the standard of care for glioma patients has largely remained the same. However, in the past year multiple practice-changing randomized trials in glioma have been published. In this Oncology Scan, we highlight 3 such trials to address how they may impact treatment
Treatment of WHO Grade 2 and 3 Gliomas With Potentially Favorable Survival: Is Monotherapy Obsolete?
No full textPrevious central nervous system oncology scans in this publication have discussed management and molecular characterization of low-grade gliomas, treatment strategies for high-grade gliomas in the elderly, emerging treatment options for glioblastoma (GBM), and molecular characterization of gliomas. Similar to trends observed in other oncologic diseases, grading gliomas by their molecular characteristics is emerging as a useful tool for identifying patients with potentially long-term survival after treatment of this disease. These patients present an opportunity to maximize survival through the judicious selection of appropriate therapies and a simultaneous challenge to minimize the long-term sequelae of these treatments. In this oncology scan, we discuss the results from 4 important trials of radiation therapy (RT) and/or chemotherapy in patients with World Health Organization (WHO) grade 2 and 3 gliomas, discussing the impact of monotherapy versus combined-modality treatment in the era of molecular grading of this disease
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Stable voters in an unstable party environment : continuity and change in Italian electoral behaviour
No full textM.24981-1999 Paolo Segatti, Paolo Bellucci and Marco Maraffi. 30 cm. A previous version of this paper was presented at a symposium on Political Parties : Changing Roles in Contemporary Democracies, held at the Center for Advanced Study in the Social Sciences of the Juan March Institute, Madrid, December 15-17, 1994. -- P.1. Includes bibliographical references (p. 56-59
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C.
No full textDE MAIESTATE / PRAESIDE M. JACOBO THOMASIO, MORALIS PHILOSOPH. P. P., PUBLICE DISPUTABIT JOHANNES DUNTE, R. L. AUTHOR & RESPON: AD DIEM 9. SEPTEMBR. H L. Q. C.
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C. (1)
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AUT902903_Supplemental_material – Supplemental material for An association of intrapartum synthetic oxytocin dosing and the odds of developing autism
No full textSupplemental material, AUT902903_Supplemental_material for An association of intrapartum synthetic oxytocin dosing and the odds of developing autism by Stephen M Soltys, Jill Rose Scherbel, Joseph R Kurian, Todd Diebold, Teresa Wilson, Lindsay Hedden, Kathleen Groesch, Paula L Diaz-Sylvester, Albert Botchway, Pamela Campbell and Julio Ricardo Loret de Mola in Autism</p
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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