1,721,415 research outputs found
Impaired magnesium status and depression
No full textMagnesium (Mg) is an element present in everyday dietary plan of regular meals, but it has been shown that a large part of the population presents a low Mg status. Mg has a wide range of physiologic and protective functions within energy regulation and cellular, included neuronal, homeostasis. It obstacles excessive calcium flow into the cells, preventing cells' death, has anti-inflammatory properties, antioxidant action, and interacts with serotonin, a central neurotransmitter involved in depression pathophysiology. Epidemiologic studies have shown that low Mg status is associated with increased frequency of depression, with both cross-sectional and longitudinal designs. Promising evidence has shown that Mg has antidepressant activity similar to imipramine, and that it can be a valid supplementation to antidepressants in treatment resistant depression. However, at the present state of the art too few and small studies have investigated the role of Mg among other therapeutic means in depression, and any conclusion about its utility in clinical practice cannot be drawn. Future research should shed a light on such an important field needing more evidence. © Springer Nature Switzerland AG 2019
Introduction to the special section on clinical high risk for mental illness: Transdiagnostic framework, detection strategies, assessment, treatment and outcome
Full text linkAdjunctive minocycline in schizophrenia: What one well-conducted study can tell us (and what it can't)
No full textSuicide
No full textOld age males have the highest rates of suicide compared to other age groups. The rates of suicide are nonetheless strikingly high even among senior women. Depression may onset in the elderly, and the old-age patients may seek for primary care or otherwise non-psychiatric consultation in a high proportion of cases. When they do not do so, suicide in the elderly may be insidious since the aged individual is poorly verbally communicative, and the final suicidal attempts bare high in terms of lethality. The prevention of suicide using the identification of relevant risk factors and optimal management is, therefore, a multidisciplinary priority for treating physicians. Antidepressant and patient-tailored social interventions are among the most relevant therapeutic approaches, although additional insights about the neurobiology and psychological factors leading to suicide in the elderly are warranted. © 2019 Elsevier Inc. All rights reserved
Learning from COVID-19 pandemic in northen italy: Impact on mental health and clinical care
Full text linkCorrigendum: Network analysis of the relationship between depressive symptoms, demographics, nutrition, quality of life and medical condition factors in the Osteoarthritis Initiative database cohort of elderly North-American adults with or at risk for osteoarthritis (Journal of Physical Chemistry (2019) DOI: 10.1017/S204579601800077X)
No full textThe above article was originally submitted to Epidemiology and Psychiatric Sciences with the incorrect author name listed for the second author. The correct surname for the second author is Ai Koyanagi (and not Ai Konayagi). The authors would like to apologise for this error. © Cambridge University Press 2019
Clozapine for persistent aggressive behaviour or agitation in people with schizophrenia
No full textThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. To examine whether clozapine is an effective treatment for the management of aggression behaviour in people with schizophrenia (i.e. not for rapid tranquillisation). Specifically, this review will focus on the efficacy on aggression, self-harm, and serious adverse effects outcomes. Secondary outcomes will focus on other aggression and agitation outcomes, global and mental state outcomes, service use, other adverse effects, reasons to leave the study early, acceptance and satisfaction of treatment, quality of life, and economic outcomes. Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd
Corrigendum: Network analysis of the relationship between depressive symptoms, demographics, nutrition, quality of life and medical condition factors in the Osteoarthritis Initiative database cohort of elderly North-American adults with or at risk for osteoarthritis (Journal of Physical Chemistry (2019) DOI: 10.1017/S204579601800077X)
No full textThe above article was originally submitted to Epidemiology and Psychiatric Sciences with the incorrect author name listed for the second author. The correct surname for the second author is Ai Koyanagi (and not Ai Konayagi). The authors would like to apologise for this error
Proportion of young people in the general population consulting general practitioners: Potential for mental health screening and prevention
No full textAim: One of the main obstacles with prevention in psychiatry is low detection of young subjects at risk for psychosis. The aim of the present work is to test whether general practitioners' (GP) offices are a possible setting for prevention of mental illness. Methods: We used an Electronic Health Record database (Datanet) representing South-London (Lambeth), where frequency of GP visits were available for each registered subject. Results: We show that in 2018 out of almost 175 000 subjects aged 12 to 35, almost six out of ten people were seen by their General practitioner at least once in 2018, and considering those subjects with at least one medical condition, around nine subjects out of ten did the same. Conclusions: A high proportion of adolescents and young adults are seen by GPs at least once per year. GP offices should be tested as possible setting for detection of subjects at risk for mental illness, in particular in subjects with risk factors for mental illness
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