2,696 research outputs found
Impronta territoriale di un prodotto alimentare. La ricerca dell’Università di Ferrara in difesa del Made in Italy
No full textL’Università di Ferrara ha lavorato negli ultimi anni su metodologie innovative di analisi geochimiche per la valutazione della qualità dei prodotti agricoli italiani: mele, pere, graminacee e vino. La ricerca è rivolta principalmente alla difesa del made in Italy e alla tutela dei prodotti di origine protetta. Adesso, con il progetto “Territorialità del Prosecco”, il team costituito da: Salvatore Pepi, Luigi Sansone, Diego Tomasi, Patrick Marcuzzo e Stefano Soligo e coordinato dalla professoressa Carmela Vaccaro del Dipartimento di Fisica e Scienze della terra dell’Università di Ferrara ha messo a punto un innovativo metodo di analisi, finalizzato a definire l'unicità di uve e vini, applicato ad uno dei più importanti distretti viti-vinicoli italiani.
Il Prosecco è un vino di eccellenza, la cui denominazione fa riferimento a un territorio definito e a un certo numero di cantine e di aziende vinicole. Data la notevole richiesta del mercato, si sono rese necessarie misure di controllo che evitino contraffazioni, tagli delle uve, usi impropri o illeciti della denominazione.
In sintesi, attraverso una serie di analisi integrate che riguardano il suolo, la composizione del prodotto (uva e vino) e le sue caratteristiche qualitative, è stato possibile definire “ l’impronta territoriale” del Prosecco, ovvero le caratteristiche che un vino deve avere, se è stato davvero prodotto nel territorio e nelle cantine che fanno parte del distretto.
L’analisi del suolo riguarda le caratteritiche geochimiche del terreno, la sua tessitura, l’impronta climatica. L’analisi della composizione chimica consente il riconoscimento del prodotto e l’individuazione delle quantità di elementi minerali (calcio, magnesio, sodio, potassio, ferro, etc.) che lo caratterizzano. La stessa analisi consente di individuare la presenza o l’assenza di componenti con caratteri di tossicità, che contribuiscono a definire la qualità del prodotto.
I risultati di queste analisi costituiscono “ l’impronta territoriale ” del prodotto, impronta che non può essere falsificata. Un vino prodotto con uve provenienti da altri territori, o anche solo tagliato con uve diverse, non può avere la stessa composizione chimica del Prosecco originale, anche se solo all’apparenza la qualità è uguale.
La metodologia applicata per la definizione dell’impronta territoriale” consente valutazioni molto mirate, al punto che sullo stesso territorio i prodotti di imprese vinicole differenti hanno impronte diverse.
Al termine del progetto, dopo una fase di caratterizzazione dei prodotti di ogni cantina, ogni impresa vinicola della zona di produzione avrà la propria impronta territoriale, informazione che potrà in futuro entrare nell’etichetta e tutelare il prodotto finito
Who is the author of the 1876 Stefano manuscript?
No full textFor over one hundred years the Stefano manuscript was a private document in the possession of the Baccich family and descendants. It told a story of the 1875 Stefano shipwreck as narrated by the shipwreck survivor and the founding family patriarch Miho Baccich. In these circumstances the question of authorship of the manuscript was immaterial and did not arise as an issue. However, with the publication of the manuscript the author‟s name, or names, need to be formally attributed to it. It turns out that this is not such a clear-cut matter.
As we shall see, all informed sources attributed the authorship, and the ownership, of the manuscript to Miho Baccich. But the manuscript itself was written by Canon Stjepan Skurla – a priest from Miho‟s hometown of Dubrovnik. The question then arises: should Skurla also be considered as an author of the manuscript, or, even as the sole author (as some would have it)
Muscarinic receptor activation modulates neurotrophic factors production in rat Schwann-like cells derived from adipose mesenchymal stem cells.
No full textMuscarinic receptor activation modulates neurotrophic factors production in rat Schwann-like cells derived from adipose mesenchymal stem cells
Piovesana R1, Faroni A2, Soligo M3, Manni L3, Reid AJ2 & Tata AM1
1Dept. Biol and Biotech. C. Darwin, University of Rome “Sapienza”, Rome, Italy; 2Blond McIndoe Lab, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; 3Institute of Translational Pharmacology-CNR, Rome, Italy
Peripheral nerve injury is commonly caused by direct mechanical trauma. Regeneration depends on the ability of Schwann cells (SCs) to create a favourable environment, by producing neurotrophic factors. Although SCs are effective in promoting nerve regeneration, they are not a convenient source of transplantable cells to improve outcomes after injury. Mesenchymal Stem Cells derived from adipose tissue (ASCs) seem to be a promising alternative source considering their ability to differentiate towards SC phenotype (Schwann-like).
SCs express different receptors for neurotransmitters. In particular cholinergic stimulation of M2 muscarinic receptor decreases SCs proliferation whilst upregulating myelination. Previously, we demonstrated that Schwann-like cells express muscarinic receptors; in particular the M2 receptor activation resulted in decreased proliferation and reduced migration.
In present work, we have characterised the effects mediated by muscarinic receptors on neurotrophic factors (NFs) expression and production. The selective activation of M2 receptors by arecaidine propargyl ester (APE) caused a significant decrease of the transcript levels for NFs (NGF, BDNF and GDNF), while the non-selective agonist muscarine did not influence NFs mRNA expression. By custom made Elisa Assay, we analysed the production of two different NGF forms, precursor (proNGF) and mature NGF (mNGF). APE treatment induced a decreased release of both NGF forms, whereas muscarine treatment stimulated an increased release of mNGF. Western blot analysis indicated that both agonists caused a significant decrease in the expression of the proNGF isoform at 25 kDa, which is likely involved in the modulation of apoptotic processes.
The data obtained suggest a relevant role of muscarinic receptors in the modulation of NFs production in Schwann-like cells. In particular the ability of both muscarinic agonists to negatively modulate the proNGF isoform, thereby suggesting a neuroprotective role of muscarinic receptors towards regenerating axons
Fashion Culture: Power In Fashion with Stefano Tonchi and Grazia d'Annunzio
No full textStefano Tonchi, global chief creative officer for L’Officiel Group, and Grazia d’Annunzio, former deputy director of Vogue Italia, discuss the power of military uniforms and their influence on high fashion. Tonchi is co-author of the book "Uniform: Order and Disorder.
Introduzione [a I cartolari del notaio Stefano di Corrado di Lavagna]
No full textSaggio introduttivo all’edizione dei frammenti dei protocolli del notaio Stefano di Corrado di Lavagna nel quale viene fatta l’analisi codicologica dei frammenti e si ricostruisce la biografia del notaio. Vengono inoltre esaminate la tipologia dei documenti, le tecniche redazionali del notaio e l’organizzazione burocratica della Chiesa genovese nella seconda metà del secolo XIII.
Introduction essay to the edition of the fragments of the protocols of the notary Stefano di Corrado of Lavagna in which the analysis of the codex fragments and reconstructs the biography of the notary is made by the author. She also examined the types of documents, the technical drafting of the notary and the bureaucratic organization of the Church of Genoa in the second half of the thirteenth century
From Lausanne to Luxembourg: the CJEU’s Seraing Judgment and the Boundaries of Sports Arbitration Under EU Law
No full textIn this expert analysis, Professor Stefano Bastianon dissects the CJEU’s landmark Seraing ruling (Case C-600/23), which reshapes the contours of sports arbitration under EU law. With particular focus on judicial review and EU public policy, the author explores how the Court balances the autonomy of arbitral mechanisms like CAS with the imperative of effective judicial protection — a judgment that could have far-reaching implications for the future of dispute resolution in sport
Recensione di Robert G. La France, Bachiacca: artist of the Medici court, Firenze, Olschki, 2008
No full textABSTRACT ITALIANO
Francesco Ubertini detto il Bachiacca ebbe scarsa fortuna critica ma questo volume di Robert G. La France colma una lacuna grave nella critica d’arte con una solida monografia in lingua inglese che prende in esame tutte le opere e i documenti di questo pittore. Stefano Colonna giudica positivamente il libro, pubblicato da Leo Olschki, limitandosi a sottolineare che alcune opere, inserite come autografe dall’autore, presentino differenti qualità.
ENGLISH ABSTRACT
Francesco Ubertini called Bachiacca has had little critical fortune, but this book by Robert G. La France fills a serious lacuna in art criticism with a solid English monograph that examines all the existing works and documents. Stefano Colonna welcomes the book published by Leo Olschki and simply points out that some of the works included by the author as autograph have a different quality
Outlining a selection procedure for Saccharomyces cerevisiae isolated from grape marc to improve fermentation process and distillate quality
No full textGerm-Layer Specification and Control of Cell Growth by Ectodermin, a Smad4 Ubiquitin Ligase
No full textTGF-beta signaling is essential for development and proliferative homeostasis. During embryogenesis, maternal determinants act in concert with TGF-beta signals to form mesoderm and endoderm. In contrast, ectoderm specification requires the TGF-beta response to be attenuated, although the mechanisms by which this is achieved remain unknown. In a functional screen for ectoderm determinants, we have identified Ectodermin (Ecto). In Xenopus embryos, Ecto is essential for the specification of the ectoderm and acts by restricting the mesoderm-inducing activity of TGF-beta signals to the mesoderm and favoring neural induction. Ecto is a RING-type ubiquitin ligase for Smad4, a TGF-beta signal transducer. Depletion of Ecto in human cells enforces TGF-beta-induced cytostasis and, moreover, plays a causal role in limiting the antimitogenic effects of Smad4 in tumor cells. We propose that Ectodermin is a key switch in the control of TGF-beta gene responses during early embryonic development and cell proliferation
The role of theragnostics in oncology: an interview with Stefano Buono
No full text Stefano Buono* speaks to Commissioning Editor, Sebastian Dennis-Beron: Stefano Buono is the Chief Executive Officer, a member of the board of directors, and a founder of Advanced Accelerator Applications (AAA). He has been responsible for overseeing AAA operations, including the development and commercialization of the current portfolio of diagnostic and therapeutic molecular nuclear medicine products, and listing AAA on Nasdaq (stock symbol: AAAP). Prior to founding the company in 2002, he worked as a physicist at the Centre for Advanced Studies, Research and Development, or CRS4, in Italy. During his 6-year tenure with CRS4, he headed a team of engineers working on different international research projects in the field of energy production and nuclear waste transmutation. Before working at CRS4, and alongside his appointment at CRS4, he worked with Physics Nobel Laureate Carlo Rubbia at The European Organization for Nuclear Research (CERN), the world’s largest research laboratory for particle physics, in Geneva, Switzerland. He actively participated in the development of CERN’s Adiabatic Resonance Crossing (ARC) method. He is the author of numerous scientific papers. He received his Master’s degree in Physics from the University of Turin, in Italy, in 1991. </jats:p
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