25 research outputs found
ORAL BIOAVAILABILITY ENHANCEMEMENT OF BROMOCRYPTINE MESYLATE BY SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
No full textObjective: The purpose of this work was to enhance oral bioavailability of Bromocryptine Mesylate by preparing SMEDDS (self-micro emulsifying drug delivery system)Methods: Screening of oils, surfactants and co-surfactants were done by solubility study & pseudo ternary diagram. The batches of Bromocryptine Mesylate (BM)–SMEDDS were prepared and evaluated for droplet size analysis, poly dispensability index (PDI), robustness to dilution, zeta potential, in vitro dissolution. The optimized batch was compared with commercially available quick release tablets of BM (Brainstar®, 0.8 mg/tablet) by in vivo study (Pharmacodynamic study in rats).Results: Based on the drug\u27s solubility study, Akoline MCM, Tween80 and PEG400 were selected as oil, surfactant and co-surfactant, respectively. By pseudo ternary diagram, the components\u27 ratios were screened. In vitro drug release of the optimized batch was lower than the commercial preparation but in in vivo study, optimized batch was similar with commercial tablets.Conclusion: From the study, it was concluded that the group treated with optimized BM-SMEDDS showed better and sustained reduction in blood sugar as compared to control group and the group treated with marketed formulation, indicated improvement in bioavailability of drug. Keywords: Bromocryptine Mesylate, Type–II Diabetes, Self micro emulsifying drug delivery system, Bioavailability, Pharmacodynamic stud
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The Praescriptionary
No full textThe Praescriptionary is a project that explores the power of stories to guide, to
empower and to heal the soul.
In the main framing tale, we find Bhavin, a grieving widower and Astrid, a patient
in a comatose state, both unable to move on with their lives. Bhavin discovers the
Praescriptionary, a magical book capable of dispensing just the right tale for the reader
(or the listener’s) soul, in a mysterious bookshop. It is when he begins reading and
sharing it with Astrid that they both began their journey towards healing.
The seven tales which the book reveals to our protagonists are nestled within the
larger frame tale so that readers may experience immersion along with the protagonists
and be startled when they surface back in the main tale, realizing that they are still within
a layer of story.
The sub-stories are original creations though there are a few re-imaginings of
existing myth or fairytales. Each tale carries within it the kernel of an impetus towards
healing for one or both of the main characters to help them on their paths to wholeness.
There is also a key psychological step towards grief recovery enmeshed deep within each
story, though each retains a unique flavor, with the exception of the linked Lost Princess
tales. This individuality is reflected in the frontispiece illustration, a composite of seven
panels of original artwork, each based on one of the seven tales and made by the author
for this work
Laboratory Model Tests on Stone Column and Pervious Concrete Columns: A Comparative Study
No full textThis study aims to perform laboratory model tests to investigate the load-deformation behavior of stone columns (SCs), pervious concrete columns (PCCs), and composite columns (CCs). Here, CC refers to the column which has the upper portion made of PCC and the lower portion made of SC. The parameters investigated in this study include column diameters, column lengths, and installation methods (pre-cast and cast-in-situ methods). The results of the model tests reveal that the axial load-carrying capacity of PCC is nearly 8 times more than that of SC with the same diameter. Moreover, it is also observed that at the top portion of SC, with the PCC length which is about 3.75 to 5 times the column diameter, the load-carrying capacity can significantly increase. It is concluded that the installation methods have marginal influence on the load-deformation behavior of PCC
Author's personal copy How emotional arousal and valence influence access to awareness
No full texta b s t r a c t The effect of emotion on visual awareness is largely unknown. Pairs of natural images were presented side by side on a screen in a binocular rivalry setup. The amount of time that each image of a pair dominated perception was computed. Our results showed: (A) A main effect of arousal: Dominance durations of the more arousing picture of iso-valence pairs were longer. (B) No effect of valence: Dominance durations of pleasant and unpleasant pictures of isoarousal pairs were similar. (C) An interaction between arousal and valence: The more pleasant picture of iso-arousal pairs of low arousal level dominated conscious perception. The less pleasant picture of iso-arousal pairs of high arousal level dominated conscious perception. Our findings suggest that the emotional content of a stimulus affects the extent to which it dominates awareness. While arousal and valence interactively affect access to awareness, only arousal exerts an independent control of such access
Galaxy Evolution in the Local and the High-z Universe Through Optical+near-IR Spectroscopy
No full textabstract: A key open problem within galaxy evolution is to understand the evolution of galaxies towards quiescence. This work investigates the suppression of star-formation through shocks and turbulence at low-redshift, and at higher-redshifts, this work investigates the use of features within quiescent galaxy spectra to redshift estimation, and passive evolution of aging stellar populations to understand their star-formation histories.
At low-, this work focuses on the analysis of optical integral field spectroscopy data of a nearby () unusual merging system, called the Taffy system because of radio emission that stretches between the two galaxies. This system, although a recent major-merger of gas-rich spirals, exhibits an atypically low star-formation rate and infrared luminosity. Strong evidence of shock heating as a mechanism for these atypical properties is presented. This result (in conjunction with many others) from the nearby Universe provides evidence for shocks and turbulence, perhaps due to mergers, as an effective feedback mechanism for the suppression of star-formation.
At intermediate and higher-, this work focuses on the analysis of Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) G800L grism spectroscopy and photometry of galaxies with a discernible 4000\AA\ break. The usefulness of 4000\AA/Balmer breaks as redshift indicators by comparing photometric, grism, and spectrophotometric redshifts (SPZs) to ground-based spectroscopic redshifts, is quantified. A spectral energy distribution (SED) fitting pipeline that is optimized for combined HST grism and photometric data, developed for this project, is presented. This pipeline is a template-fitting based routine which accounts for correlated data between neighboring points within grism spectra via the covariance matrix formalism, and also accounts for galaxy morphology along the dispersion direction. Evidence is provided showing that SPZs typically improve the accuracy of photometric redshifts by 17--60\%. For future space-based observatories like the Nancy Grace Roman Space Telescope (formerly the Wide Field InfraRed Survey Telescope, i.e., WFIRST) and Euclid, this work predicts 700--4400 galaxies\,degree, within , for galaxies with 4000\AA\ breaks and continuum-based redshifts accurate to 2\%.
This work also investigates the star-formation histories of massive galaxies (). This is done through the analysis of the strength of the Magnesium absorption feature, Mgb, at 5175\AA. This analysis is carried out on stacks of HST ACS G800L grism data, stacked for galaxies binned on a color vs stellar mass plane.Dissertation/ThesisDoctoral Dissertation Astrophysics and Astronomy 202
Serosurveillance among COVID-19 Cases in Ahmedabad Using SARS-COV2 IgG Antibodies
No full textBackground: Serosurveillance study focusing on antibodies against SARS-CoV2 among the Covid19 cases can add value in the scientific knowledge & help in formulating valid predictions regarding immunity status in the post-covid period. Objectives: To estimate seropositivity among covid19 cases and to identify various factors affecting seropositivity. Methods: During second half of October 2020, a population based serosurvey on Covid19 cases was carried out in Ahmedabad. Covid-Kavach test kits were used and estimated seroprevalence was compared with available demographic and covid19 case related parameters to identify factors affecting seropositivity in the post-covid period. Simple proportions and Z-test were used as appropriate. Results: As on October 2020, the sero-positivity among Covid19 cases in Ahmedabad was 54.51% [95% Confidence Interval (CI) 52.14-56.86%]. Females have higher positivity (54.78%) as compared to males (54.30%) but the difference was statistically not significant (Z=0.19, P=0.84). Among children and elderly, the positivity is high and from young adults to elderly the seropositivity has an increasing trend. Severity of clinical illness and longer duration of hospitalization are associated with higher seropositivity. Conclusion: With 54.51% seropositivity among covid19 cases, it is clear that all the covid19 cases may not have developed IgG antibodies, have undetectable level or might have disappeared during the post-covid period. Comparison of seropositivity with age group and clinical case details clearly suggest close correlation with the severity of clinical symptoms. The seronegative cases indicate the need for further in-depth scientific research to identify the factors affecting immunity and to uncover the reasons behind the same
A rare entity of acute bilateral cortical renal necrosis following acute pancreatitis
No full textAcute bilateral renal cortical necrosis following acute pancreatitis is extremely rare condition. Among all cases of acute renal failure, the incidence of renal cortical necrosis was 3.8% in one of the study in North India. Till date, only eight cases of bilateral cortical necrosis following acute pancreatitis were reported in the literature. We report a case of a 27-year-old male patient with abdominal pain, nausea and vomiting since 2 days duration and anuria since 24 h. Serum amylase and lipase were raised, and elevated serum creatinine was noted on admission. Contrast-enhanced computed tomography scan of the abdomen revealed changes of acute pancreatitis with hypoenhancement of renal cortex compared to medulla on both sides (reverse rim sign-stronger enhancement of the renal medulla compared to cortex), suggest an acute renal cortical necrosis
Assessment Of Long-Term Outcome Among New Smear Positive Pulmonary TB Patients Treated with Intermittent Regimen Under RNTCP – A Retrospective Cohort Study
No full textBackground: Under the Revised National TB Control Programme (RNTCP) of India, treatment of TB is given as thrice weekly regimen following WHO recommended DOTS strategy and the success of treatment is largely declared based on completeness and bacteriological conversion. Once the patient is declared as cured or treatment completed, they are not followed up under the programme unless they come to the health system again with symptoms. Present study was conducted to assess status of patients at 2 years after successful anti-TB treatment under DOTS and to explore any potential impact of treatment irregularity on long term outcome
Methods: In this retrospective cohort study, all new smear positive (NSP) pulmonary TB cases declared as cured or treatment completed from were included in the study. They were interviewed, after 24 months from date of declaration of successful treatment, using semi-structured questionnaire. Patient TB treatment card and Tuberculosis registers were also used to collect desired information.
Results: A total of 657 out of 706 successfully treated NSP TB patients were included in the study. Out of these, 326 (49.6%) patients had any interruption during their treatment. The average number of doses missed during intensive phase and continuation phase was 7.5 and 11.9 respectively. Average duration of any interruption during treatment was 6.5 days. No significant difference was observed in proportion of treatment interrupters and non-interrupters across demographic variables except for a higher proportion of treatment interruption in patients enrolled from urban district. Out of 657 subjects, 71 (10.85%) had relapse of TB. Another 39 (5.9%) patients died due to TB. These unfavourable outcomes were not significantly different among treatment interrupters and treatment non-interrupters.
Conclusion: After being successfully treated, the new smear positive pulmonary TB patients had a very high proportion of relapse of TB. Treatment non-adherence was not significantly associated with long term unfavourable outcomes
