254 research outputs found
Reply to: Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature
No full textPMID = 2768713
Isotretinoin use for acne vulgaris is associated with increased serum uric acid levels
No full textA few previous case reports related vitamin A and retinoid use with elevated serum uric acid (SUA) levels. Recently, a population based study showed an independent positive correlation of serum retinol with SUA levels. Despite increasing importance of SUA in a number of disease states, no study has examined the association between retinoids and SUA. We aimed to evaluate the effect of pharmacologic dose isotretinoin on SUA level. This was a cohort study in which 51 consecutive adult patients with severe acne vulgaris who were prescribed oral isotretinoin treatment (0.5mg/kg) were included. Dermatologic examination was performed and SUA levels were measured at study inclusion for each participant, and then repeated at the first and second months of therapy. SUA levels at first month and second month were significantly higher than baseline SUA levels (p: 0.001, 0.007, respectively). SUA levels at second month were higher than SUA levels at first month, but the difference did not reach statistical significance. This study is the first to show that pharmacologic dose oral isotretinoin treatment significantly increased SUA levels. Since hyperuricemia is associated with renal disease, hypertension, atherosclerosis and metabolic syndrome as well as gout, it is important for the dermatologist to be aware of this potential adverse effect of isotretinoin particularly in vulnerable patients
Single-Dose, Open-Label Study of the Differences in Pharmacokinetics of Colchicine in Subjects with Renal Impairment, Including End-Stage Renal Disease
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The relationship between serum uric acid and chronic kidney disease among Appalachian adults
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Plasma BNP, a useful marker of fluid overload in hospitalized hemodialysis patients
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Non-infected hemodialysis catheters are associated with increased inflammation compared with arteriovenous fistulas
No full textThe relationship between neutrophil to lymphocyte ratio and metabolic syndrome in patients with type 2 diabetes
No full textMetabolic syndrome (MetS) has been shown to be associated with inflammation. However, in diabetic patients with MetS, its relationship with the neutrophil to lymphocyte ratio (NLR) as a novel inflammation marker is unclear. The aim of the study was to investigate the association between NLR and MetS in patients with type 2 diabetes mellitus. It was a cross-sectional study which included 261 consecutive patients (mean age 56.7 +/- 10.5 years, 56.7% female) with type 2 diabetes. NLR and other clinical and laboratory parameters of patients with and without MetS were evaluated. The prevalence of MetS was 85.8%. The NLR was higher in patients with MetS than without MetS (p = 0.001). There was a significant correlation between the NLR and the number of MetS components (r = 0.147, p = 0.017). Logistic regression analysis showed that an elevated NLR value was an independent predictor of MetS. The receiver operating curve analysis suggested that the optimum NLR cut-off point for MetS was 1.50 with a sensitivity of 74.6% and specificity of 52%. There is a significant relationship between NLR and MetS prevalence in patients with type 2 diabetes mellitus. NLR seems as an independent predictor of MetS in diabetic patients
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