1,721,176 research outputs found
Transcriptomic analysis of cellular senescence: one step closer to senescence atlas
No full textSenescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context of senescent cells, in vivo studies are needed to increase the understanding of senescent cells. Since current methods are often unable to distinguish senescent cells from other cells, efforts are being made to find markers commonly expressed in senescent cells using bulk RNA-sequencing. Moreover, single-cell RNA (scRNA) sequencing, which analyzes the transcripts of each cell, has been utilized to understand the in vivo characteristics of the rare senescent cells. Recently, transcriptomic cell atlases for each organ using this technology have been published in various species. Novel senescent cells that do not express previously established marker genes have been discovered in some organs. However, there is still insufficient information on senescent cells due to the limited throughput of the scRNA sequencing technology. Therefore, it is necessary to improve the throughput of the scRNA sequencing technology or develop a way to enrich the rare senescent cells. The in vivo senescent cell atlas that is established using rapidly developing single-cell technologies will contribute to the precise rejuvenation by specifically removing senescent cells in each tissue and individual.
Electronic Nose based on Transistor with Polymer Films
No full textE-nose, polymer film, IGZO TFTNⅠ. INTRODUCTION 1
1.1 Motivation 1
1.2 Human olfactory system 2
1.2.1 Human nose receptors 2
1.2.2 Human nose receptors array 4
1.3 Multi-array sensor 6
1.4 E-nose based on polymer 7
1.4.1 Polymer application 7
1.4.2 Mechanism of sensing with non-conductive polymer 8
1.4.3 Mechanism of interaction with odorants 10
1.5 E-nose based on transistor 12
Ⅱ. EXPERIMENTAL DETAILS 13
2.1 Device structure and concept 13
2.2 Device material 15
2.3 Device fabrication 15
2.4 Measurement systems 19
Ⅲ. CHARACTERISTICS OF α-IGZO TFT AND E-NOSE WITH POLYMER FILMS 21
3.1 Electrical characteristics of the α-IGZO TFT with polymer films 21
3.2 Odorant response of the α-IGZO TFT and the α-IGZO TFT with polymer films 24
Ⅳ. THE METHOD FOR ENHANCING THE CHRACTERISTICS OF E-NOSE 25
4.1 Enhancement of the sensitivity 25
4.1.1 Advantage of the 3-terminal device 25
4.1.2 Control of the polymer’s thickness 27
Ⅴ. PERFORMANCE OF ELECTRONIC NOSE 30
5.1 Classification of interaction between polymer films and odorants 30
5.1.1 Category of interaction 30
5.1.2 Odorant sensing performance of E-nose for 8-odorants 31
5.1.3 Selectivity of the α-IGZO TFT with polymer films 44
5.1.4 The result of multi-array sensor in saturation region 51
Ⅵ. CONCLUSION 52MasterdCollectio
Ashley Sohee Kim, piano
No full textProgram for recital offered in partial fulfillment of the requirements for the degree of Bachelor of Music
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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