1,720,975 research outputs found
Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalermin for intramuscular use in peripheral neuropathies
No full textPeripheral neuropathies are frequently encourtered in clinical practice and are assiociated with a major impairment in quality of life . Howewvwr, their management reamans poor, and current therapies are often burdened with major side effects and can present poor efficacy on pain and functionality. Therefore, it has been suggested that the combination of two or more different drugs may improve analgesis efficacy and reduce side effects. Tricortin 1000 is formulated with 12 mg of Brain cortex phospholipid liposomes + 1000 microgrammi of Cyanocobalamin injectable (PL+ CNCb1) for intramuscolar use and is indicated in the tratment of poly-algo-neuropathic syndromes. This combination exerts a marked neurotrophic action by promoting the syntesis of endogenous phospholipids; moreover the peculiar formulation optimized the delivery of CNCb1 wich has analgesis and neurotrophic action. This paper discusses the pharmacotherapy of peripheral neuropathies, including low back pain, neck pain, post herpetic neuropathy (PHN) and focuses on the fixed dose combination PL+CNCb1 ckinical efficacy in association with other treatment or in monotherapy
Combination of Rehabilitative Therapy with Ultramicronized Palmitylethanolamide for Chronic Low Back Pain: An Observational Study
Full text linkChronic low ba,:k pain (LBP) caused by intervertebral disc herniation was reported in the 2010 Global Burden of Disease study to be the main reason for;zears lived wittL disability. It causes significant personal, social, and economic burdens. Many of those who suffer from LBP find convent:ional medica.l treatments to be unsatisfactory for treating their pain, so they are increasingl'g resorting tcr complementary and alternalive medicine (CAM) therapies. Given that thr: population ir; aging, there is an urgent need to characterize the combinations of complementary therapie:; that yield the best outcomes and treatments, even for prolonged periods. The multiple action of PEA in connbination with CAVI therapies may represent the multitarget approachr needed trc tackle the as-yet unsolved problem of chronic pain resistant to conventional therapie
Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A randomized Clinical Trial
Full text linkBackground and Objectives: In the Western world, back pain and sciatica are among the
main causes of disability and absence from work with significant personal, social, and economic
costs. This prospective observational study aims to evaluate the effectiveness of a rehabilitation
program combined with the administration of Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol,
and Cholecalciferol in the treatment of sciatica due to herniated discs in young patients in terms of
pain resolution, postural alterations, taking painkillers, and quality of life. Materials and Methods: A
prospective observational study was conducted on 128 patients with sciatica. We divided the sample
into 3 groups: the Combo group, which received a combination of rehabilitation protocol and daily
therapy with 600 mg Alpha Lipoic Acid, 1000 mg Acetyl-L-Carnitine, 50 mg Resveratrol, and 800 UI
Cholecalciferol for 30 days; the Reha group, which received only a rehabilitation protocol; and the
Supplement group, which received only oral supplementation with 600 mg Alpha Lipoic Acid, 1000
mg Acetyl-L-Carnitine, 50 mg Resveratrol, and 800 UI Cholecalciferol. Clinical assessments were
made at the time of recruitment (T0), 30 days after the start of treatment (T1), and 60 days after the end
of treatment (T2). The rating scales were as follows: the Numeric Rating Scale (NRS); the Oswestry
Disability Questionnaire (ODQ); and the 36-item Short Form Health Survey (SF-36). All patients
also underwent an instrumental stabilometric evaluation. Results: At T1, the Combo group showed
statistically superior results compared to the other groups for pain (p < 0.05), disability (p < 0.05), and
quality of life (p < 0.05). At T2, the Combo group showed statistically superior results compared
to the other groups only for pain (p < 0.05) and quality of life (p < 0.05). From the analysis of the
stabilometric evaluation data, we only observed a statistically significant improvement at T2 in the
Combo group for the average X (p < 0.05) compared to the other groups. Conclusions: The combined
treatment of rehabilitation and supplements with anti-inflammatory, pain-relieving, and antioxidant
action is effective in the treatment of sciatica and can be useful in improving postural stabilit
IS THERE A RELATIONSHIP BETWEEN MILD-MODERATE BACK PAIN AND FRAGILITY FRACTURES? ORIGINAL INVESTIGATION
No full textIntroduction: Fragility fractures are the cause of 43 thousand deaths: 50% are caused by femur fractures, 28% by vertebral fractures and 22% by various fractures in women, in men the percentages are 47%, 39% and 14% respectively. Vertebral fractures are the most common, 30-50% women over age 50 will experience one of them. Worldwide, is estimated that a new vertebral fracture occurs every 22 seconds. Additionally, vertebral fractures strongly predict the risk of both further fractures and re-fractures, in any skeletal segment. Vertebral fractures are often asymptomatic. Early diagnosis of these is extremely important. The aim of the study is to show, within a population of women over-50 in post-menopause, the correlation between mild-moderate back pain and fragility fractures, pain intensity and number of fractures to decide an early diagnostic path reducing new fractures risk. Materials and method: This observational study was conducted between January 2016 and January 2018 with a total examination of 4000 physiatric outpatient, 615 were over 50 years old woman with back pain for at least 3 months not responding to conservative treatment and with NRS between 2 and 4; 513 patients have been enrolled in this study. All patients are physiatric outpatient at the U.O.C. of Rehabilitation of University Hospital “P. Giaccone” of Palermo. We include Post-menopausal women over 50, having intermittent back pain for for at least 3 months, not responding to conservative treatment, with NRS between 2 and 4 and SF 36 between 60 and 100. We do not include patient with rheumatological pathologies, recent traumas, bone metastasis, osteomyelitis and previous vertebral fracture. All patients underwent a instrumental examination was also conducted with a dorsal-lombar X-Ray (L/L), in standing position. The semi-quantitative morphometric Genant method was used for the diagnosis of the vertebral fractures. Result: Data analysis showed that 41% (213/513) have vertebral fractures at dorsal-lombar X- Ray in L/L projection, using the semi-quantitative morphometric Genant method. 685 vertebral fractures have been shown with an average of 3.2 per patient: 74,59% are dorsal vertebral fractures and 24.1% are lombar. 77.5 % (165) of patients referred an NRS rate between 2 and 3 (first group) and 22.5% (48) a rate of 4 (second group). 66.1% of patients belonging to the first group showed more than 3 fractures and 33.9% from 1 to 2 vertebral fractures. 89.6% of patients belonging to second group has more than 3 fracture, 10.4% from 1 to 2 vertebral fractures. The Fischer test showed a P-value <0,001 regarding correlation between NRS and number of vertebral fragility fractures. Conclusion: As we underline in the introduction, vertebral fractures are usually asymptomatic and, consequently undiagnosed. This observational study demonstrate that mild-moderate back pain, in post menopause woman resistant to conservative therapy and still with a good quality of life, is a significant symptom for an early diagnosis of vertebral fragility fractures. © 2020 A. CARBONE Editore. All rights reserved
Efficacy of extracorporeal shock wave therapy and nutraceutical supplementation in the treatment of lateral epicondylitis: a randomized controlled trial
Full text linkIntroductionNumerous scientific papers have compared different treatment options in the management of lateral epicondylitis. Our study evaluated the efficacy of focal extracorporeal shock wave treatment (ESWT) combined with an integrative nutraceutical treatment of hyaluronic acid, collagen, vitamin C, and manganese, compared with single treatment in patients with lateral epicondylitis in terms of improvement of pain, functional capacity, muscle strength, and reduction of inflammation on ultrasound images.MethodsA single-center, randomized controlled trial (RCT) was conducted in a population of patients with lateral epicondylitis. Patients were enrolled and randomly divided into 3 groups: Group A, consisting of 15 patients who were treated with twenty sessions of therapeutic exercise and five focal ESWT sessions (one session every six days); Group B, consisting of 15 patients who performed twenty sessions of therapeutic exercise and took daily a dietary supplement consisting of Hyaluronic Acid 200 mg, Collagen 5,000 mg, Vitamin C 250 mg and Manganese 10 mg for thirty days; and Group C, consisting of 15 patients, who received a combined treatment of therapeutic exercise, focal ESWT and nutraceutical supplementation The Numerical Rating Scale (NRS) and Patient-Rated Tennis Elbow Evaluation Scale (PRTEE) were administered during the first physiatric examination (T0), at 15 days after the start of treatment (T1), and at a 30-day follow-up (T2). In addition, muscle strength (Handgrip strength) was analyzed by means of a dynamometer, and common extensor tendon thickness (CET Thickness) by ultrasound examination.ResultsData analysis showed that NRS scale scores decreased significantly only in group B at T1 (P < 0.05), and in the three groups at T2 (P < 0.05). Grip strength increased significantly after 30 days only in group C (P < 0.05), while PRTEE scores and CET Thickness decreased significantly at T2 in the three groups (P < 0.05). The comparison among the various groups also showed that the Group C showed statistically significant improvements of function and grip strength at T2, compared with the other groups (P < 0.05).DiscussionOur study demonstrated that the combination of focal ESWT, therapeutic exercise, and nutraceutical supplementation, represent a viable therapeutic option for the management of lateral epicondylitis; likewise, the proposed treatments resulted in a synergistic effect for pain relief and functional recovery in the short term, providing a decrease in the inflammatory state and an increase in muscle strength
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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