112,329 research outputs found
Conversations between Interiors
No full text The point of departure of this article is a collaborative installation work in whose creation one of the authors (Remco Roes) participated. The article combines a visual essay, composed from images documenting both the final exhibition and the process leading up to it, and a written commentary that attempts to point at—or point out—how knowledge or thinking may occur within or through a sequence of images such as this. These two essays, and the oblique relationship between them, are designed to shed light not only on one specific work of art but, more generally, on how we may inhabit different kinds of interiors, whether or not they are purely “physical.” It also reflects on the visual essay genre as itself a way of thinking through artistic, design and philosophical problems. </jats:p
The New Classical Counter-Revolution: False Path or Illuminating Complement?
No full textIn this paper the author responds to Laurence Seidman’s recent article, ‘The New Classical Counter-Revolution: A False Path for Macroeconomics’. The author challenges the view that new classical macroeconomics has been a false path and provides a critique of Seidman’s arguments with respect to his interpretation of the 1970s ‘stagflation’, the relevance of new classical macroeconomics for practical policymaking, the contribution of real business cycle theory, and the new classical content of contemporary macroeconomic textbooks. The author concludes that the new classical counter-revolution has had an extremely productive influence on the current mainstream new neoclassical synthesis framework.
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Evolution of adaptive route choice behaviour in drivers
No full textTraffic assignment, the process by which vehicle origin-destination flows are loaded on to discrete paths traversing a road network, has been traditionally approached as a non-linear optimisation problem where it is expected that travellers will each minimise their own travel time. While such models are suitable for obtaining an `average’ expected network state, traffic conditions on a day to day basis are inherently uncertain due to variations in travel patterns and incidents such as vehicle breakdowns, roadworks or bad weather resulting in fluctuations in realised traffic flows. Further, such models do not consider the transition from one `average’ state to another when an aspect of infrastructure is changed such as a new road opening or the introduction of long term roadworks. This paper therefore examines the evolution of driver route choice over time in stochastic time-dependent networks, specifically focusing on how individual experience of network conditions guides future decisions and its relationship with en-route switching opportunities. Existing algebraic and empirical models of route choice evolution are assessed (particularly using discrete whole path choices to assess benefits of information provision) and it is proposed that incorporating adaptive path routing based on expected correlations in traffic flow behaviour is more suitable than fixed path models for capturing the extent of observed uncertainty in network conditions. We present this issue and explore through simulation a model where drivers adapt expected road link travel times for a given trip based on a combination of previous experience and discovered link travel times on that trip. We show how adaptive behaviour produces travel times which are on average faster than non-adaptive behaviour, confirming the potential of this modelling approach. <br/
The Wealth and Poverty of Nations: François Bourguignon on Fifty Years of Economic Development and the Elusive Quest for Sustained Growth
No full textFrançois Bourguignon was Chief Economist and Senior Vice President, Development Economics, at the World Bank before taking up his current position as Director of the Paris School of Economics. He is one of the world’s leading economists in the field of economic growth and development, in particular the relationship between growth, poverty and income distribution. To set the interview in context, Brian Snowdon first provides a brief discussion of several contemporary issues in economic development, including the recently published Commission on Growth and Development Report. In the interview that follows, discussion ranges over several subjects and key issues including Latin America; the fall and rise of development economics; changing conventional wisdom on the role of government; World Bank development research; measuring development; poverty, inequality and development; the Millennium Development Goals; convergence and divergence clubs; growth and inequality; democracy and development; geography v. institutions; globalisation; migration and development; foreign aid and development; improving the business and investment climate; the ‘Stern Report’ and climate change; culture, religion and development; and the IMF, World Bank and WTO
The Wealth and Poverty of Nations
No full textFrançois Bourguignon was Chief Economist and Senior Vice President, Development Economics, at the World Bank before taking up his current position as Director of the Paris School of Economics. He is one of the world’s leading economists in the field of economic growth and development, in particular the relationship between growth, poverty and income distribution. To set the interview in context, Brian Snowdon first provides a brief discussion of several contemporary issues in economic development, including the recently published Commission on Growth and Development Report. In the interview that follows, discussion ranges over several subjects and key issues including Latin America; the fall and rise of development economics; changing conventional wisdom on the role of government; World Bank development research; measuring development; poverty, inequality and development; the Millennium Development Goals; convergence and divergence clubs; growth and inequality; democracy and development; geography v. institutions; globalisation; migration and development; foreign aid and development; improving the business and investment climate; the ‘Stern Report’ and climate change; culture, religion and development; and the IMF, World Bank and WTO.
Využití sociálních médií v B2B prodeji
No full textTato diplomová práce se zabývá tím, jak mohou B2B obchodníci využívat sociální média v prodeji. Na základě systematické rešerše literatury, autor zjistil, že akademici, zkoumající danou problematiku, navrhují další výzkum, a to: v kterých konkrétních krocích se dají využít sociální média v prodeji (Salo, 2017). Autor se na základě toho rozhodl zjistit, jaké sociální sítě, různé technologie a pluginy se dají využít v B2B prodeji - tzv. social sellingu. Social selling se v této práci týká primárně procesu akvizice a okrajově péčí o stávající zákazníky. Autor si vybral kvalitativní průzkum pomocí 10 hloubkových polo-strukturovaných rozhovorů, aby odhalil jak, která sociální média to jsou, tak i motivaci prodejců, proč tato média používat/nepoužívat. Aby autor dodržel správnost vyhodnocení výsledků, data byla analyzována pomocí Tématické analýzy, která v této studii vykrystalizovala 2 hlavní strategické přístupy v social sellingu. Tyto přístupy (tzv. Push a Pull strategie) obsahují praktické příklady a konkrétní aktivity, které mohou prodejci využívat v každodenní praxi. Tyto výsledky jsou prezentovány s důrazem na praktičnost a jednoduchost implementace. Tvoří proto hlavní přínos autorovo výzkumu. V poslední části autor zmiňuje výzvy a manažerská doporučení, které mohou obchodníci využít v každodenním pracovním životě.This diploma thesis focuses on social media usage in B2B sales. Based on the systematic literature review conducted by the author, he has found out that recent researchers (Salo, 2017) suggest further research in the area of how and in which sales phase should various social networking sites, technologies and plugins used. To further fill this research gap, author decided to identify these social media and their usage among B2B salespeople in the so-called social selling process. The social selling process in this thesis applies mainly to acquiring new prospects and tangentially to taking care of existing clients (follow-up step). Author has chosen a qualitative research method via conducting 10 in-depth semi-structured interviews to reveal these instruments as well as motivation of a sales person on why to use social media in the selling process. The collected data was analyzed using Thematic analysis to ensure the right procedure and to identify main themes which crystalized into 2 main strategic approaches in social selling. These approaches (Push and Pull) include practical examples of concrete activities which sales people can use in their daily jobs and are presented with focus on practicality and ease of implementation. These also form the main contribution of author`s research. In the last part, author mentions challenges in social selling and recommended managerial implications for salesforce
Relaxin as a therapeutic haemodynamic modulator in liver disease
No full textINTRODUCTION:
Hepatorenal syndrome (HRS) is a common complication of advanced cirrhosis with a
high mortality rate and limited treatment options. Central to its pathogenesis is severe, but potentially
reversible, renal vasoconstriction leading to functional renal failure. Current pharmacological
treatment using splanchnic vasoconstrictors is suboptimal and prognosis without liver transplantation
is dismal. The peptide hormone relaxin (RLN) mediates haemodynamic adaptations to pregnancy
including increased renal blood flow (RBF) and glomerular filtration rate (GFR). I hypothesised that
exogenous RLN could be used therapeutically to improve RBF and renal function in the context of
experimental cirrhosis and HRS.
METHODS:
To address this I generated pathologically distinct rat models of liver cirrhosis with
features of human HRS including renal vasoconstriction and renal failure. Compensated cirrhosis
was induced in male rats by 16 weeks of i.p. carbon tetrachloride (CCl4) and decompensated
cirrhosis by bile duct ligation (BDL). I studied the effects of acute i.v. or sustained (72 hr) s.c.
infusion of RLN compared with vehicle on systemic haemodynamics, RBF, GFR and kidney
histology. I used blood oxygen dependent-magnetic resonance imaging (BOLD-MRI) to detect
changes in kidney parenchymal oxygenation and Doppler ultrasound to monitor changes in RBF
(velocity time integral, VTI) and renal arterial resistance (resistive index, RI). Hepatic and renal
expression of the relaxin receptor RXFP1 was determined by quantitative polymerase chain reaction
(qPCR) and immunohistochemistry (IHC). Vascular functional responses in isolated renal arteries
were assessed by wire myography. Relaxin mediated changes in key vaso-regulatory signalling
pathways in the kidney and renal vessels were analysed by qPCR, IHC and ELISA.
RESULTS:
I showed using in vitro myography that the pathophysiological mechanism that underlies
renal vasoconstriction in experimental cirrhosis models is an impairment of endothelium-dependent
vasodilatation. Selective targeting of renal vasoconstriction using relaxin improved renal blood flow,
tissue oxygenation, and normalized glomerular filtration rate in both compensated and
decompensated rat cirrhosis. Furthermore, relaxin treatment restored endothelium-dependent
vasodilation in isolated renal vessels from CCl4 cirrhotic rats. Relaxin-induced effects on renal blood
flow and glomerular filtration rate were mediated though activation of the AKT/eNOS/nitric oxide
signalling pathway in kidney, though systemic nitric oxide levels were unaffected. Crucially for
human translation, relaxin did not reduce mean arterial blood pressure even in advanced cirrhosis.
CONCLUSION:
My findings identify relaxin as the first potential targeted treatment reversing the
vascular dysfunction which causes HRS and directly improving renal function in HRS. Clinical
translation in carefully selected populations is warranted
- …
