1,358 research outputs found
Total Synthesis of (−)-FD-838 and (−)-Cephalimysin A
No full textWe
completed a nine-step total synthesis of (−)-FD-838 and
(−)-cephalimysin A. Our synthesis features a biogenetically
guided assembly of the highly oxidized spirocyclic core by Snider-type
tandem epoxidations of the chiral substrate derived from an amino
acid derivative. Our synthetic approach provides a general and versatile
solution to access spirocyclic PKS-NRPS-based secondary fungal metabolites
Total Synthesis of (−)-FD-838 and (−)-Cephalimysin A
No full textWe completed a nine-step total synthesis of (−)-FD-838 and (−)-cephalimysin A. Our synthesis features a biogenetically guided assembly of the highly oxidized spirocyclic core by Snider-type tandem epoxidations of the chiral substrate derived from an amino acid derivative. Our synthetic approach provides a general and versatile solution to access spirocyclic PKS-NRPS-based secondary fungal metabolites.
Synthesis of (−)-TAN-2483A. Revision of the Structures and Syntheses of (±)-FD-211 (Waol A) and (±)-FD-212 (Waol B)
No full textThe structure of waol A has been revised from 1 to 6, the vinylogue of TAN-2483 A (5). Aldol reaction of 10b(c) with 2,4-hexadienal (11) affords
9b(c), which is subjected to iodoetherification with bis(sym-collidine)IPF6 to provide 8b(c). Treatment with Et3N in CH2Cl2 completes three-step
syntheses of TAN-2483A (5) and waol A (6)
Synthesis of (−)-TAN-2483A. Revision of the Structures and Syntheses of (±)-FD-211 (Waol A) and (±)-FD-212 (Waol B)
No full textThe structure of waol A has been revised from 1 to 6, the vinylogue of TAN-2483 A (5). Aldol reaction of 10b(c) with 2,4-hexadienal (11) affords
9b(c), which is subjected to iodoetherification with bis(sym-collidine)IPF6 to provide 8b(c). Treatment with Et3N in CH2Cl2 completes three-step
syntheses of TAN-2483A (5) and waol A (6)
Evaluation of CAN-FD Protocol for Traffic Signalling
No full textU ovom diplomskom radu je evaluiran CAN-FD protokol u svrhu upravljanja prometnom signalizacijom. Naglasak je stavljen na ispitivanje karakteristika protokola u realnim uvjetima te je zbog toga razvijen elektronički modul koji simulira funkcionalnosti LED modula čijim kaskadiranjem se dobiva promjenjivi prometni znak veće površine. Opisane su razlike između CAN 2.0B i CAN-FD protokola te su opisane funkcije pojedinih okvira u jednom CAN-FD paketu. U poglavljima koji se tiču razvoja programske podrške je opisano kako se konfiguriraju generatori signala takta te osnovne inicijalizacije sustava, kao i verifikacija pojedinih segmenata programskog koda. Osim razvoja sklopovlja i programske podrške pokazan je i način odabira adekvatnog mikrokontrolera u smislu karakteristika, kućišta te cijene.In this master thesis author evaluated new CAN-FD communications protocol for use in controlling dynamic traffic signs. Protocol testing was done on a custom made embedded system that simulates the funcionality of a real LED module used in dynamic signs. The differences between CAN-FD and CAN2.0B and the functions are described in the third chapter. Clock configuration and system initialization are described in the chapters regarding development of a software solution for this system as well as testing individual code segments to verify their functionality. In addition to the development of hardware and software this thesis also considers the selection of an adequate microcontroller in terms of characteristics, package and price
Snider, John (Death, 1869-08-11)
No full textAddress: 332 VineAge at death: 53153/Pg 169/1869/MWS/Philadelphia/Dr. Quinn/Jones FD/City Cem.Original record filed in drawer labeled 'SMITH-SNYDE'
Regulation FD: SEC Reestablishes Enforcement Capabilities over Selective Disclosure.
No full textThis Recent Development focuses on the potential effects Regulation Fair Disclosure (FD) will have on the participants in the American capital market and on the stock markets themselves. Congress and the Securities Exchange Commission (SEC) seek to achieve confidence in the integrity and fairness of the American stock market and protection of investors from fraud by promoting equal opportunities for investors. In order to maintain a competitive edge, vis-à-vis its foreign counterparts, the United States must continually refine its financial systems to maximize fairness and integrity. This Recent Development focuses on selective disclosure—allowing a limited segment of investors access to information about a company’s financial performance—along with the inability of existing securities regulations to prohibit such practices. The recently promulgated Regulation FD is a measure anticipated to reign in the disclosure of nonpublic information to a privileged few. Specific requirements within the Regulation FD are examined by the author, and the SEC intends for the Regulation FD to level the playing field for investors. Furthermore, this Recent Development addresses potential trouble areas caused by the regulation’s interplay with other securities rules and regulations. In addition to suggestions for compliance, the various touchstones of controversy such as the effects related to Regulation FD on the securities industry are also discussed. Regulation FD molds a remedy to the perceived evils of selective disclosure. Confidentiality agreements represent the SEC’s strategy for controlling selective disclosure, without expressly authorizing it. This Recent Development concludes with an assessment of the practical effects that Regulation FD will have on the securities industry and the likelihood that it is here to stay
A Millimeter-Wave Front-End for FD/FDD Transceivers Featuring an Embedded PA and an N-Path Filter Based Circulator Receiver
No full textThis work presents an ultra-compact single-antenna FD/FDD transceivers front-end. It comprises a nonreciprocal circulator, RX, and an integrated power amplifier (PA). In the proposed circulator, we devise a ring quarter-wave transmission line topology with adjusted characteristic impedances to improve TX-to-antenna insertion loss and TX-to-RX isolation. Besides, an AND-gate switching-based N-path filter is proposed to realize the circulator's nonreciprocal gyrator while acting as a mixer-first RX. Owing to the ultra-compact N-path filter structure, the circulator occupies only 0.38mm 2 core area. Over a 27.1-to-31.1GHz band, the realized front-end offers >20dB TX-to-RX isolation while its measured TX-to-antenna insertion loss is 1.7~2.2dB. The RX path tolerates the PA's blocker signal, achieving 5dBm in-band and 13dBm out-of-band B 1dB. Moreover, the PA delivers 15.15dBm peak output power with 33% drain efficiency. Our front-end prototype occupies only 0.7mm 2 , including circulator, PA, quadrature hybrid coupler LO generators, and baseband circuits.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
() Jackknife results for the PD- and FD- libraries: yellow squares indicate hits detected from the PD- library, blue squares indicate hits detected from the FD- library and green squares indicate hits detected from both the libraries
No full text<p><b>Copyright information:</b></p><p>Taken from "Detecting DNA-binding helix–turn–helix structural motifs using sequence and structure information"</p><p>Nucleic Acids Research 2005;33(7):2129-2140.</p><p>Published online 14 Apr 2005</p><p>PMCID:PMC1079965.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> Incorrectly aligned hits are highlighted with slashes and crosses: forward slashes (/) indicate incorrectly aligned hits detected from the FD- library, backward slashes (\) indicate incorrectly aligned hits detected from the PD- library and crosses (X) indicate incorrectly aligned hits detected from both the libraries. () Jackknife results for the combination of PD- and FD- libraries and the method of 3D-templates. Green squares indicate hits detected from either the FD- library or the PD- library or both; red squares indicate hits detected from the method of 3D-templates; and brown squares indicate hits detected from all the three methods
Risk of screening adherence by category of FD practices.
No full textA. FDs (the markers correspond to the practice baricenter and marker colors to adherence category) plotted against SARs for small triangular areas (about 0.50 km2). B. Top panel: crude adherence rates (left) and (right) by FD practices. Bottom panel: marginal predicted adherence probability for low adherence FDs and high participation FDs and, for comparison, adherence probability for a generic person at average level of covariates. Figure was created by the author Bianconi F. combing the caterpillar, bar plots and maps generate with GeCO-sys an extension of [21].</p
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