1,721,876 research outputs found
Smith, Patrick, NX35359
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/417812Surname: SMITH. Given Name(s) or Initials: PATRICK. Military Service Number or Last Known Location: NX35359. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 21996.240828
Item: [2016.0049.50073] "Smith, Patrick, NX35359
Dataset supporting the University of Southampton Doctoral Thesis "Investigating the molecular mechanisms that underpin M. tuberculosis and Dendritic cell interactions"
No full textDataset supporting the University of Southampton Doctoral Thesis "Investigating the molecular mechanisms that underpin M. tuberculosis and Dendritic cell interactions".
The data contains Bioinformatics Scripts underpinning the research. The files include the R and Python scripts. </span
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Exploring the molecular mechanisms that underpin M. tuberculosis and dendritic cell interactions
No full textDendritic cells (DCs) are essential to the development of protective immunity through their potent ability to present antigens to T-cells. Once activated, T-cells promote the proliferation of antibody-producing cells and use antigen-targeted, cytotoxic mechanisms to neutralise infectious agents. In diseases such as Tuberculosis (TB), ineffective T-cell responses lead to uncontrolled dissemination of the pathogen, indicating that T-cells can be crucial to disease outcome. Phagocytic cells, in contrast, are believed to facilitate the survival of Mycobacterium tuberculosis (Mtb) in the host, by providing a protective, intracellular niche from other patrolling immune cells. As DCs are phagocytic and prime inducers of T-cell responses, they may play a central role in TB pathogenesis.In this study, transcriptomic data from TB-infected patients and Mtb-infected DCs were analysed and compared to identify signatures of genes that may allude to a distinct response of DCs to Mtb. This began with a comparison between bulk RNA-seq and microarray datasets derived from DC’s infected with Mtb or challenged with other pathogens/pathogen-associated molecular patterns. A 211 gene signature was found to distinguish Mtb-infected DCs from other conditions, and contained within were genes related to a range of processes including antigen presentation and iron regulation. Principal component analysis further suggested the transcriptomic profile of DCs diverges from other pathogens in response to Mtb. This signature was used to extrapolate a pattern of gene expression in bulk RNA-seq data derived from the lymph nodes of TB-infected patients. Using gene co-expression networks, 406 genes were found to be highly associated with the in vitro signature. Importantly, this showed that a DC-related pattern of gene expression could be detected in the lymph nodes, critical sites for antigen presentation. Similar to the in vitro signature, genes associated with iron regulation, production of reactive oxygen species and production of the antioxidant glutathione, were found.In addition, two in vivo datasets, one derived from the lung tissue and the other derived from the blood of TB-exposed individuals were analysed to identify genes modulated in response to TB exposure. Across the two datasets, DC subpopulations: cDC1, cDC2, pDC and pre-DCs (AXL+SIGLEC6+) were identified, indicating that DCs were present in clinical samples. In addition, 896 genes were found to be differentially modulated across all DC subtypes, and included genes associated with iron regulation, superoxide metabolism and fatty acid synthesis.Combining the DC signatures from each set of analyses indicated that SAT1, a gene involved in polyamine synthesis was upregulated in all three signatures. Combined with other genes found in at least two chapters, SAT1, TFRC, FTH1 and FTL enriched Ferroptosis, an iron-dependent cell death mechanism driven by an imbalance of fatty acid synthesis, iron-generated oxygen radicals and glutathione production, through gene ontology. Differential gene expression analysis showed consistent modulation of 34 genes in the pathway in Mtb-infected DCs and TB-infected lymph nodes. The modulation of some of these genes was found to be recapitulated in an in vitro cell culture model with monocyte-derived dendritic cells at the mRNA level using RT-qPCR and at the protein level for Haemoxygenase-1, Transferrin Receptor (CD71) and Prion Protein (CD230) using flow cytometry. Lipid peroxidation, a hallmark of Ferroptosis was shown to increase in infected DCs and correlated with cell death, suggesting Mtb-infection was driving the modulation of Ferroptosis genes, leading to increased lipid peroxidation and cell death. Finally, immunohistochemistry was used to show that Thioredoxin, a gene associated with Ferroptosis, was more prevalent in TB-infected lymph nodes compared to control tissue. Combined these findings provide compelling evidence that Ferroptosis, a mechanism known to increase cell death and suppress antigen presentation is driven by Mtb-infection. Ultimately, reduced DC function in clinical settings may result in a limited immune response and sustained infection.<br/
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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