336 research outputs found

    Madelyn Smith Oral History Interview Records

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    Madelyn Smythia of Sewanee, Tennessee was interviewed by Kendoll Hayes, Sewanee student, on February 15th, 2024 in person/on Zoom. While their conversation was primarily on the Black Lives Matter Movement, other topics included: Smythia’s experiences with racism during her childhood and history education in Tennessee Public Schools. We hope that this conversation will assist scholars with a further understanding of race in the United States during the early twenty-first century. Please click on the link to see the full interview.Dr. Andrew Maginn, Visiting Assistant Professo

    <b>Supplemental Material - Dawn of a New Normal: Resident and Faculty Attitudes in Adopting Virtual Conferences and Education</b>

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    Supplemental Material for Dawn of a New Normal: Resident and Faculty Attitudes in Adopting Virtual Conferences and Education by Frank Madelyn, Stopenski Stephen, Yamamoto Maki, Nahmias Jeffry, Nguyen Ninh T, Smith Brian R, and Keshava Hari B in The American Surgeon</p

    Exploring crystallographic compatibility in polycrystalline Cu-based shape-memory alloys

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    This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, June, 2019Cataloged from the official PDF version of thesis.Includes bibliographical references (pages 47-49).Shape-memory alloys (SMAs) are a class of materials that can recover from apparent permanent strain (on the order of 5%) due to a solid-to-solid phase transformation. It has been recently suggested that SMAs satisfying a set of so-called cofactor conditions possess perfect interface compatibility and additional microstructural flexibility during transformation, which are theorized to result in excellent reversibility. Cu-based SMAs are cheaper than other alternatives, but polycrystalline Cu-based SMAs are unable to withstand many cycles because they are prone to cracking and degradation of functional properties. Previous research has identied improved shape-memory properties in Cu-Al-Ni-Mn SMAs in the oligocrystalline state, but polycrystalline material of the same composition has yet to be characterized. In this thesis, I characterize the compatibility of Cu-Al-Ni-Mn alloys according to the cofactor conditions and correlate these findings with results from superelastic mechanical cycling. Building on this knowledge, I also present a new alloy design that is predicted to meet the cofactor conditions and provides a promising path forward for a functionally stable, low-cost, polycrystalline Cu-based SMA.by Madelyn Payne.S.B.S.B. Massachusetts Institute of Technology, Department of Materials Science and Engineerin

    Simulating Metal-Imidazole Complexes

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    One commonly observed binding motif in metalloproteins involves the interaction between a metal ion and histidine’s imidazole side chains. Although previous imidazole-M(II) parameters established the flexibility and reliability of the 12-6-4 Lennard-Jones (LJ)-type nonbonded model by simply tuning the ligating atom’s polarizability, they have not been applied to multiple-imidazole complexes. To fill this gap, we systematically simulate multiple-imidazole complexes (ranging from one to six) for five metal ions (Co(II), Cu(II), Mn(II), Ni(II), and Zn(II)) which commonly appear in metalloproteins. Using extensive (40 ns per PMF window) sampling to assemble free energy association profiles (using OPC water and standard HID imidazole charge models from AMBER) and comparing the equilibrium distances to DFT calculations, a new set of parameters was developed to focus on energetic and geometric features of multiple-imidazole complexes. The obtained free energy profiles agree with the experimental binding free energy and DFT calculated distances. To validate our model, we show that we can close the thermodynamic cycle for metal-imidazole complexes with up to six imidazole molecules in the first solvation shell. Given the success in closing the thermodynamic cycles, we then used the same extended sampling method for six other metal ions (Ag(I), Ca(II), Cd(II), Cu(I), Fe(II), and Mg(II)) to obtain new parameters. Since these new parameters can reproduce the one-imidazole geometry and energy accurately, we hypothesize that they will reasonably predict the binding free energy of higher-level coordination numbers. Hence, we did not extend the analysis of these ions up to six imidazole complexes. Overall, the results shed light on metal-protein interactions by emphasizing the importance of ligand-ligand interaction and metal-π-stacking within metalloproteins

    Saint Louis University Cheerleaders, members of the 1962 squad in mid jump

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    SLU Cheerleaders, members of the 1962 squad in mid jump. From left to right: Mary Ellen Nunley, Madelyn Smith, Lila Reise, Leah Sturm, and Kathy Lauber. (07 November 1962) [Photo by Father Luke, PHO 01.929b.57

    Understanding government influence on healthcare legislation

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    Understanding government influence on healthcare legislation Author: Madelyn J. Miles Mentor: Sarah Kercsmar, Ph.D. Department: College of Health Sciences Research Objective: Healthcare is constantly evolving and changing. One of the strongest influencers in this constant change is the government. In order to completely understand healthcare, one must also be able to understand the legislation involved. For providers, this is important to understand since they need to be aware of the resources available to their patients. Being informed about health laws allows providers to make more educated decisions, understand trends in healthcare, and stay compliant with updated standards. The vocabulary, terminology, and overall process used in legislation can be difficult to understand—especially to a lay audience. This study examines recent healthcare laws in Kentucky to better understand whether current legislation aligns with the greatest health needs of the state and to determine better ways of presenting the information in a way individuals from any educational background can understand. Methods: Laws passed in 2017 were selected for review from Kentucky’s Legislative Research Commission website and compared to the priorities identified in the Foundation for a Healthy Kentucky’s “Kentucky Health Issues Poll”. Information from the comparison was then translated into a podcast series. Podcasts were uploaded to researcher’s Facebook, Instagram, Twitter, and YouTube. Podcasts include news clips and interviews with professionals who have experience working in areas affected by these new laws. The series consists of six-episodes and was titled “What the Health is Going on?” Conclusions: The findings suggest that Kentucky has a strong healthcare presence in legislation and that many of the laws overlapped with the priority issues identified by the Foundation. Although some laws were irrelevant to the greatest issues, they may still play an important role in improving healthcare in the state. Overall, the study findings indicate that Kentucky is taking steps to improve major healthcare issues, but there is still room for priority alignment with legislation

    Saint Louis University Cheerleaders, members of the 1962 squad in mid jump

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    SLU Cheerleaders, members of the 1962 squad in mid jump. From left to right: Mary Ellen Nunley, Madelyn Smith, Lila Reise, Leah Sturm, and Kathy Lauber. (07 November 1962) [Photo by Father Luke, PHO 01.929b.55

    Birmingham News sleeve BN0040751

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    Nativity scene / Kids portray 3 kings, angels, shepherds in nativity scene. / 227 Poinciana Drive, Homewood / Jeff Hindman / Jeff Smith / Phil Scott / Kings / Brian Gerard / Madelyn Christie / Mary and Joseph / Brian Fink - shepherd / Molly Scott - angel / [Work order included
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