7,042 research outputs found

    Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA

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    Brain-derived neurotrophic factor (BDNF) plays a facilitatory role in neuronal development and promotion of differentiation. Mechanisms that oppose BDNF's stimulatory effects create balance and regulate dendritic growth. However, these mechanisms have not been studied. We have focused our studies on the BDNFinduced neuropeptide OrphaninFQ/Nociceptin (OFQ); while BDNF is known to enhance synaptic activity, OFQ has opposite effects on activity, learning and memory. We have now examined whether OFQ provides a balance to the stimulatory effects of BDNF on neuronal differentiation in the hippocampus. Golgi staining in OFQ knockout (KO) mice revealed an increase in primary dendrite length as well as spine density, suggesting that endogenous OFQ inhibits dendritic morphology. We have also used cultured hippocampal neurons to demonstrate that exogenous OFQ has an inhibitory effect on dendritic growth and that the neuropeptide alters the response to BDNF when re-administered. To determine if BDNF and OFQ act in a feedback loop, we inhibited the actions of the BDNF and OFQ receptors, TrkB and NOP using ANA-12 and NOP KO mice respectively but our data suggests that the two factors do not act in a negative feedback loop. We found that the inhibition of dendritic morphology induced by OFQ is via enhanced RhoA activity. Finally, we have evidence that RhoA activation is required for the inhibitory effects of OFQ on dendritic morphology. Our results reveal basic mechanisms by which neurons not only regulate the formation of proper dendritic growth during development but also control plasticity in the mature nervous system.This is the peer reviewed version of the following article: Alder, J., Kallman, S., Palmieri, A., Khadim, F., Ayer, J. J., Kumar, S., Tsung, K., Grinberg, I. and Thakker-Varia, S. (2013), Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. Devel Neurobio, 73: 769–784, which has been published in final form at https://dx.doi.org/10.1002/dneu.22101. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Peer reviewe

    Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata

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    The priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes

    A Unified Shell model for Buoyancy-Driven Turbulence

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    We construct a unified shell model for stably stratified and convective turbulence. Shell model simulation of stably stratified flow in turbulent regime exhibit Bolgiano-Obukhbov (BO) scaling in which the kinetic energy spectrum varies as k11/5k^{-11/5}. However, simulation of convective turbulence shows Kolmogorov's spectrum. These results are consistent with the direct numerical simulations of Kumar {\em et al.} [Phys. Rev. E {\bf 90}, 023016 (2014)]. We also observe a dual scaling (k11/5k^{-11/5} and k5/3k^{-5/3}) for a limited range of parameters in stably stratified flow

    Author Index

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    Author Inde

    FIGURE 2 in A new species of the amphipod genus Quadrivisio (Senticaudata, Maeridae) from Chilika Lagoon, India

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    FIGURE 2. Quadrivisio chilikensis sp. nov., male, paratype, 9 mm, ZSI/EBRC/Cr14098: (A) Gnathopod 1; (B) Gnathopod 2; (E to I): Pereopod 3 to pereopod 7; female, paratype, 9.5 mm, ZSI/EBRC/Cr14099, (C) Gnathopod 1; (D) Gnathopod 2.Published as part of Bhoi, Gitanjali, Myers, Alan A., Tarafdar, Lipika, Smita, Moili, Jena, Ajay Kumar & Patro, Shesdev, 2023, A new species of the amphipod genus Quadrivisio (Senticaudata, Maeridae) from Chilika Lagoon, India, pp. 36-42 in Zootaxa 5256 (1) on page 39, DOI: 10.11646/zootaxa.5256.1.2, http://zenodo.org/record/774526

    FIGURE 1 in A new species of the amphipod genus Quadrivisio (Senticaudata, Maeridae) from Chilika Lagoon, India

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    FIGURE 1. Quadrivisio chilikensis sp. nov., female, holotype, 9.5 mm, ZSI/EBRC/Cr14097, (A) Complete body, male, paratype, 9 mm, ZSI/EBRC/Cr14098; (B) Maxilliped; (C) Maxilla 1; (D) Maxilla 2; (E) Mandible; (F) Lower lip; (G) Uropod 1; (H) Uropod 2; (I) Uropod 3; (J) Telson; (K) Epimeron 1-3.Published as part of Bhoi, Gitanjali, Myers, Alan A., Tarafdar, Lipika, Smita, Moili, Jena, Ajay Kumar & Patro, Shesdev, 2023, A new species of the amphipod genus Quadrivisio (Senticaudata, Maeridae) from Chilika Lagoon, India, pp. 36-42 in Zootaxa 5256 (1) on page 38, DOI: 10.11646/zootaxa.5256.1.2, http://zenodo.org/record/774526

    Story of the Story-Teller: A Conversation with Ramendra Kumar

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    Ramendra Kumar (Ramen) is an award-winning writer, storyteller and inspirational speaker with 42 books to his name.  Ramen’s writings have been published by many of the leading publishers in the county and translated into 30 languages. They have found a place in several textbooks and anthologies. He has written across all genres ranging from picture books to adult fiction, satire, poetry, travelogues, biographies and on issues related to parenting and relationships. He has been invited to literary festivals held in Denmark, Greece, Sharjah, Sri Lanka as well Indian events including the prestigious Jaipur Litfest to conduct storytelling sessions and creative writing workshops. He has also been empanelled by Pearson India Education Services as well as several schools to conduct workshops. He was nominated as a Jury Member for the Best Children’s Author Category of The Times of India’s ‘Women AutHer’ Awards 2020. Many of his stories have been showcased by popular audio streaming, apps both within and outside the country, such as Spotify, Gaatha, Talking Stories Radio – London et al. An Engineer & an MBA, Ramen was serving as the General Manager (Corporate Communications), SAIL, Rourkela Steel Plant, when he took Voluntary Retirement to pursue his passion, in August 2020. To know more about the writer, you can visit his website www.ramendra.in & his page on Wikipedia.  Dr. Sagar Kumar Sharma interviews the author and unfolds the pages of his life. &nbsp

    SEASONAL INCIDENCE OF MAJOR INSECT PESTS IN SOYBEAN [Glycine max (L.) Merrill]

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    Akhilesh Kumar*, Ashwin Patel, Smita Singh*, BK Tiwari*, Rajesh Singh* and AK Pande

    Quadrivisio chilikensis Bhoi & Myers & Tarafdar & Smita & Jena & Patro 2023, sp. nov.

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    <i>Quadrivisio chilikensis</i> sp. nov. Bhoi, Myers & Patro <p> <b>Type Material:</b> Female holotype. 9.5mm (ZSI / EBRC /Cr14097),near Nalabana island (19°41'30.69"N, 85°17'53.2"E), from <i>Chaetomorpha</i> sp., 18/08/2021, Coll. Gitanjali Bhoi, Lipika Tarafdar and M. Smita.</p> <p> <b>Paratypes.</b> ZSI / EBRC /Cr14099, 1 female, 9.5 mm, ZSI / EBRC /Cr14100, 1 female, 9 mm & ZSI / EBRC / Cr14101, 1 female, 8.5 mm, same data as holotype.</p> <p>ZSI / EBRC /Cr14098 (Slides of body parts) 1 male, 9 mm, same data as holotype.</p> <p> <b>Etymology:</b> The species is named after the lagoon Chilika from which the type specimens were collected.</p> <p> <b>Diagnosis.</b> Pleonites and urosome with carina.Antenna 1 primary flagellum with more than 40 articles.Antenna 2 flagellum twice the length of peduncular article 5. Pereopods 6 and 7 equal in length. Epimeron 3 hind margin smooth.Telson inner margin without setae, outer margin with one pair of plumose setae medially.</p> <p> <b>Description.</b> Based on male paratype, 9.5 mm</p> <p> <b>Head.</b> <i>Cephalic</i> lobe broad. <i>Eyes</i> divided into two parts. <i>Antenna 1</i> peduncle much shorter than flagellum; first and second peduncular articles subequal; third peduncular article about one sixth length of second; primary flagellum composed of more than 40 articles; accessory flagellum with six articles reaching beyond the 10 th article of the primary flagellum. <i>Antenna 2</i> peduncular articles 4 and 5 subequal in length; flagellum twice length of peduncular article 5 with 20-25 articles.</p> <p> <i>Mandible</i> with 6 spines in spine row; molar process prominent; mandible palp article 1 two thirds length of article 2, without setae; article 3 longer than article 2, with 2 terminal setae. <i>Maxilla 1</i> inner plate very broad withdistal plumose setae; outer plate with 9 apical robust setae; palp with 6-7 robust setae and few fine setae. <i>Maxilla 2</i> inner plate, inner margin with double row of setae; outer plate with double row of terminal setae. <i>Maxilliped</i> inner plate reaching middle of outer plate; inner plate with 3 terminal robust setae and a row of fine setae; palp article 3 subequal in length with article 2.</p> <p> <b>Pereon.</b> <i>Gnathopod 1</i> slender; basis stout, subequal in length with coxa; carpus and propodus subequal in length; propodus subrectangular, slightly narrowing distally, anterior proximal and posterior distal margin with transverse rows of robust setae, palm convex; dactylus fitting palm, very stout basally and very slender apically.</p> <p> <i>Gnathopod 2</i> basis longer than propodus; basis short, cup-shaped; propodus pyriform, widest proximally, posterior margin with groups of robust setae, palm very oblique, defined by 2 robust setae; dactylus stout, nearly straight and equalling length of palm.</p> <p> <i>Pereopod 3</i> subequal in length with pereopod 5. <i>Pereopod 4</i> shorter than pereopod 3. <i>Pereopod 5-7</i> basis expanded, distal margin with robust setae and hind margins serrated. <i>Pereopods 6</i> and <i>7</i> equal in length.</p> <p> <b>Pleon.</b> Carina present on pleon and urosome. <i>Epimera 1-3</i> with a dorso-lateral spine on each side. <i>Uropod 1</i> peduncle longer than rami; endopod slightly longer than exopod. <i>Uropod 2</i> peduncle about equal in length to endopod which is longer than exopod. <i>Uropod 3</i> peduncle reaching to end of endopod of uropod 2; exopod subequal with endopod, thin leaf-like in structure, with short marginal setae; rami 3 times length of peduncle.</p> <p> <i>Telson</i> reaching to end of peduncle of uropod 3, deeply cleft with 3-4 terminal robust setae; outer margin with a pair of plumose setae, inner margin without setae.</p> <p> <b>Female holotype.</b> Female with sexually dimorphic characters. Gnathopod 2 smaller than that of male; propodus narrower, palm much shorter and less oblique; dactylus overlapping palm. Rami of uropod 3 a little smaller than those of the male. Rest of the characters are similar to the male.</p>Published as part of <i>Bhoi, Gitanjali, Myers, Alan A., Tarafdar, Lipika, Smita, Moili, Jena, Ajay Kumar & Patro, Shesdev, 2023, A new species of the amphipod genus Quadrivisio (Senticaudata, Maeridae) from Chilika Lagoon, India, pp. 36-42 in Zootaxa 5256 (1)</i> on pages 37-40, DOI: 10.11646/zootaxa.5256.1.2, <a href="http://zenodo.org/record/7745263">http://zenodo.org/record/7745263</a&gt

    NOTICE!!! This person (known as Ashwin Kumar) plagiarized the text titled: "Using phenomenological research methods in qualitative health research"

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    EDITORIAL NOTICE: 1. This publication has been removed due to detected plagiarism by the editorial. 2. If you have cited, you MUST UPDATE your reference with the following original article: Wojnar, Danuta, and Kristen Swanson. “Phenomenology An Exploration”. Journal of holistic nursing : official journal of the American Holistic Nurses’ Association 25 (01 October 2007): 172-80; discussion 181. https://doi.org/10.1177/0898010106295172.     _________________________________________  3. Submitter's Profile Record (the thief, the plagiariser): Name: Ashwin KumarURL: http://www.freewebs.com/ak2146Affiliation: University of Western Sydney, Australia.Country: AustraliaBio Statement:Dr. Ashwin Kumar,PO Box 571,Toongabbie,Sydney,Australia, NSW, 2146.Homepage: http://www.freewebs.com/ak2146Email: [email protected] [email protected]: 0432-622-147Skype Internet Phone ID: ak2146 Dr. Ashwin Kumar (BA, MA (Distinction), PhD) is an academic researcher whose research interests and areas of expertise include: Complementary and alternative medicine (CAM), ageing and social gerontology, sociology, social anthropology, sociology of care, public health, health promotion, Indigenous health, migrant and refugee health, disability and chronic illness. Ashwin is the author of 8 books and numerous academic journal articles in the field of public health, health sociology and anthropology of health and illness. His books: The Lived Experience of Caring; The Lived Experience of Ageing; The Lived Experience of Using Complementary and Alternative Medicine; Doing Sociology; The Basics of Sociology; Plain English Writing; Research and Writing Skills and Writing Effective Essays are available at:  http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&sort=relevancerank&search-alias=books&field-author=PhD.%20Ashwin%20Kumar  My homepage: http://www.freewebs.com/ak2146  ________________________________________
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