877 research outputs found
Interview with Cathy Ulrich
No full textThis spring, the students in UND’s ENGL 414 workshop (The Art of Writing Fiction) read a collection of micro and flash fictions titled Ghosts of You, by Cathy Ulrich. With its use of second person and a penchant for turning tropes of crime fiction on their heads, this book is a must read. Three ENGL 414 students had the opportunity to interview the author via email to discuss Cathy Ulrich’s intentions in Ghosts of You, as well as her own personal writing techniques. To borrow from how each story in Ghosts of You begins, “The thing about being the [interviewer] is you set the plot in motion.” Floodwal
History of Education in Manatee County
No full textLocal historian and author, Cathy Slusser, discusses the history of early education in Manatee County
Outer Cover : Dedicated to Cathy
No full textThe cover states that the design was dedicated to the American girl "Cathy" who had showed the author "Where It's At".The cartoon serves as a vinyl cover which includes all the artists part of the release. There is no clear indication of a title although a list of songs and musicians have been included
Migrant Health: A Key Issue For Global Health - 25 May 2011
No full textLONDON - Good health care for the one billion migrants around the world is vital if global health for all is to be achieved and maintained, according to Cathy Zimmerman of the Gender Violence and Health Centre at The London School of Hygiene & Tropical Medicine - author of the first article in a series devoted to Migration And Health in the medical journal: PLoS Medicine, for which she is one of the editors
Young people's help-seeking: an alternative model
No full textThis article is based on a study of young people's help-seeking. Fifty-five qualitative interviews with young people aged 13–14 are analysed to take account of stage process models. It is argued that while the models do have relevance to young people's help-seeking, they have two key limitations. First, they ignore problem legitimization. Second, they do not accord a place in young people's currenthelp-seeking to prior help-seeking pathways. The view that stage process models represent help-seeking as individualized and static led to the formulation by the author of an alternative help-seeking model, in which problem legitimization from micro to macro levels is incorporated alongside young people's prior helpseeking pathways. <br/
The Hormone of Desire: The Truth Sexuality, Menopause and Testosterone (bookcover)
No full textJacket design by Susan Mitchell Cover photograph © Sky Bergman Author photograph by Cathy Copelan
Interview with Armando Hugo Ortiz Guerrero
No full textCathy Ragland interviews music historian and author, Armando Hugo Ortiz Guerrero.https://scholarworks.utrgv.edu/cathyraglandrec/1003/thumbnail.jp
A Role for Metabotropic Glutamate Receptors in Healthy Ageing
No full textThe proportion of older individuals globally is increasing. This results in an increase in socioeconomic costs as more people are living long enough to suffer from the detrimental effects of ageing such as chronic age-related diseases. Thus, there is an urgent need to understand the mechanisms that drive ageing and promote healthy ageing. Ageing research using simple model organisms has shown that ageing can be modulated by genetic and environmental factors and these interventions extend lifespan and improve health in evolutionarily distant organisms. In this thesis, the fruit fly, Drosophila melanogaster was used to study the role of metabotropic glutamate receptors (mGluR) in biological ageing. mGluRs are highly conserved G-protein coupled receptors activated by the amino acid, L-glutamate to modulate intracellular signal transduction cascades, including the PI3K and MAP/ERK signalling pathways which play evolutionary conserved roles in animal ageing. By utilising a null mutation of the gene encoding the single fly mGluR we have found that loss of mGluR activity in flies causes sex-specific differences on longevity. This sex-specific effect was found to be strain-specific and may be partly attributed to differences in DmGluRA mRNA levels. This study also aimed to elucidate the mechanism(s) by which loss of mGluR extends lifespan. Phenotyping studies revealed that the long-lived mutants were associated with several phenotypes including increased resistance to stress, body weight and differences in triglyceride usage under starvation conditions. The studies also appear to rule out some possible mechanisms for the lifespan extension associated with loss of mGluR in Drosophila such as dietary restriction and improvements in gut physiology. RNA-Seq analysis also identified several genes which change in expression as a response to loss of mGluR signalling, many of which may explain the phenotypes observed and so are potential mechanisms of longevity. Further studies are required to fully understand the mechanisms of lifespan extension but taken together, the results form a case for mGluR as a novel ageing regulator
Modulation of ageing by genetic knock-out, phototherapy and drugs in the C. elegans worm
No full textAssisting healthy ageing is a key goal of 21st century healthcare. Caenorhabditis elegans is an attractive model species for ageing studies because of its short life cycle (ca. 3 days), its rapid development, and the homology of its genome with that of humans. Clinical phenotypic studies indicated that different flavin-containing monooxygenase (FMO) and various diol compounds had a role in longevity extension in C. elegans. New, endogenous functions of FMOs in C. elegans were determined, including fmo-4, the loss of which resulted in significant phenotypic differences and enhanced lifespan, compared with wild type worms. Nuclear magnetic resonance (NMR) spectroscopy-based metabolite analyses of extracts of different C. elegans FMO mutants at different life stages and of diol-treated worms revealed biochemistry that correlated with genotype and influence on lifespan. Meanwhile, as seen in studies with higher model organisms, irradiation of C. elegans with 670 nm red light also increased ATP levels, improved mitochondrial dynamics and enhanced worm motility. Infra-red (1072 nm) exposure was already reported to increase C. elegans lifespan. The effects of the chemical, physical and genetic interventions on C. elegans provide clues about the mechanisms and possible strategies to extend healthy lifespan in human old age
Ras signaling in aging and metabolic regulation
No full textAberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation. Here, I review the current evidence for Ras signaling in these newly discovered roles highlighting the interactions between the Ras pathway and other longevity assurance mechanisms. Defining the role of Ras signaling in maintaining age-related health may have important implications for the development of interventions that could not only increase lifespan but also delay the onset and/or progression of age-related functional decline
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