742 research outputs found
DNA binding of a short lexitropsin
No full textFootprinting, capillary electrophoresis, molecular modelling and NMR studies have been used to examine the binding of a short polyamide to DNA. This molecule, which contains an isopropyl-substituted thiazole in place of one of the N-methylpyrroles, is selective for the sequence 5?-ACTAGT-3? to which it binds with high affinity. Two molecules bind side-by-side in the minor groove, but their binding is staggered so that the molecule reads six base pairs, unlike the related natural products, which tend to bind to four-base-pair sequences. The result suggests that high affinity and selectivity may be gained without resort to very large molecules, which may be difficult to deliver to the site of action.Graphical AbstractFootprinting, capillary electrophoresis, molecular modelling and NMR studies have been used to examine the binding of 5 to DNA. This molecule, which contains an isopropyl-substituted thiazole in place of one of the N-methylpyrroles, is selective for the sequence 5?-ACTAGT-3? to which it binds with high affinity. Two molecules bind side-by-side in the minor groove, but their binding is staggered so that the molecule reads six base pairs, unlike the related natural products, which tend to bind to four-base-pair sequences. The result suggests that high affinity and selectivity may be gained without resort to very large molecules, which may be difficult to deliver to the site of action
Practical HPLC methodology and applications B. Bidlingmeyer, Wiley, Chichester, 1992. Pages: x + 452. £45.50. ISBN 0-471-57246-2.
No full text
Mearuring the orientation and roation rate of 3D printed particles in turbulence
No full textThe orientation distribution and rotations of anisotropic particles in turbulent flows play a key role in many applications ranging from icy clouds to papermaking and drag reduction in pipe flow. However, experimental access to time-resolved orientations of anisotropic particles has not been easy to achieve. The use of 3D printing opens up the possibility to fabricate a wide range of particle shapes with smallest dimension down to 300 μm. So far, we have printed rods, crosses, jacks, triads, tetrads and helical particle shapes. We extract particle orientations from stereoscopic video images using a method of least squares optimization in Euler angle space. We find that in turbulence, the orientation and rotation-rate of many particles can be understood using a simple picture of alignment of both the vorticity and a long axis of the particle with the Lagrangian stretching direction of the flow
Bibliografia di Umberto Romagnoli
No full textA complete bibliography of Umberto Romagnoli writings, introduced by a few lines by editors of the Journal and completed by an essay by Alberto Mattei dealing with some technical aspects of the collection of the
bibliography interwoven with some scholarly life moments of the author
The Challenges Of Politicizing Justice And The Anthropology Of Law [desafios Da Politização Da Justiça E A Antropologia Do Direito]
No full textThe article discusses the challenges faced by an anthropology of law that focuses on western modern societies and on the analysis of the justice system in its relation to issues such as violence against women and violence against the elderly. Building on the debates within the legal-feminist theories, the following subjects are explored: (1) the relationship between universalism and different forms of particularism, (2) the opposition between judicialization of social relations and the politicization of justice, (3) new forms of control that characterize contemporary societies. The author points out the limitations and fallacies of the concept of culture in the understanding of contemporary legal and political dilemmas.532475492Corrêa, M., (1983) Morte Em Família: Representações Jurídicas E Papéis Sexuais, , Rio de Janeiro, GraalCorrêa, M., (1981) Os Crimes Da Paixão, , São Paulo, Editora BrasilienseDebert, G.G., A antropologia e os novos desafios nos estudos de cultura e política (1997) Revista Política E Trabalho, (13)Debert, G.G., Beraldo de Oliveira, M., Os modelos conciliatórios de solução de conflitos e a violência doméstica (2007) Cadernos Pagu, (29)Debert, G.G., Gregori, F., As delegacias especiais de polícia e o projeto gênero e cidadania (2002) Gênero E Cidadania, , in CORRÊA, M. (org.), Campinas, PAGU - Núcleo de Estudos de Gênero, Coleção EncontrosDebert, G.G., Gregori, F., Violência e Gênero: Novas propostas, velhos dilemas (2008) Revista Brasileira De Ciências Sociais, 23 (66)Debert, G.G.E., Oliveira, A.M., A polícia e as formas de feminização da violência contra o idoso (2007) São Paulo Em Perspec-tiva, 21, p. 2Geertz, C., O saber local: Fatos e leis em uma perspectiva comparativa (1999) O Saber Local: Novos Ensaios Em Antropologia Interpretativa, , in C. Geertz, Editora VozesGilligan, C., (1982) Uma Voz Diferente, , Rio de Janeiro, Rosa dos TemposGregori, M.F., Os sentidos políticos do direto à diferença (2000) Novos Estudos CEBRAP, (57)Lins de Barros, M.M., (1987) Autoridade E Afeto. Filhos E Netos Na Família Brasileira, , Rio de Janeiro, Zahar EditoresMoore, S.F., History and the redefinition of custom on kilimanjaro (1989) History and Power in the Study of Law - New Directions in Legal Anthropology, , in J. Starr & J. F. Collier, Ithaca, NY, Cornell University PressNader, L., Up the anthropologist - perspectives gained from studying up (1969) Rein-venting Anthropology, , in Hymes, D. (Ed.), New York, Vintage BooksPierucci, A.F., (2000) Ciladas Da Diferença, p. 34. , São Paulo, EditoraRifiotis, T., As delegacias especiais de proteção à mulher no Brasil e a 'judicialização' dos conflitos con-jugais (2003) Anuário 2003. Direito E Globalização, , Rio de Janeiro, Atas do Seminário do GEDIM, Universidade Cândido MendesRios, R.R., Por uma perspectiva feminista no debate jurídico (2002) Cadernos Themis, 3 (3)Rose, N., Government and control (2000) British Journal of Criminology, 40 (1)Werneck Vianna, L., (1999) A Judicialiazação Da Política E Das Relações Sociais No Brasil, , Rio de Janeiro, Reva
Comment on "the exact seismic response of an ocean and a N-layer configuration" by G.G. Drijkonnigen and J.T. Fokkema. Reply Commentaire sur "reponse sismique exacte d' un ocean et configuration a n-couches" par G.G. Drijkoningen et J.T. Fokkema. Reponse
No full textGlobal vulnerability to near-Earth object impact
No full textA clear appreciation of the consequences resulting from an asteroid impact is required in order to understand the near Earth object (NEO) hazard. Three main processes require modelling to analyse the entire impact event. These are the atmospheric entry phase, land impact events and ocean impact events. A range of impact generated effects (IGEs) are produced by different impact scenarios. It is these IGEs that present the threat to human populations world wide, and the infrastructure they utilise. A software system for analysing the NEO threat has been developed, entitled NEOimpactor, to examine the social and economic consequences from land and ocean impacts. Existing mathematical models for the three principal impact processes have been integrated into one complete system, which has the capability to model the various effects of a terrestrial asteroid impact and, critically, predict the consequences for the global population and infrastructure. Analysis of multiple impact simulations provides a robust method for the provision of an integrated, global vulnerability assessment of the NEO hazard. The primary graphical outputs from NEOimpactor are in the form of ‘relative consequence’ maps, and these have been designed to be comprehensible to a non-specialist audience. By the use of a series of multiple-impact simulations, the system has identified the five countries most at risk from the impact hazard, as well as indicating the various factors influencing vulnerability
Spruce Mills
No full textPhotograph - Stacks of lumber at Spruce Mills, Athabasca, Alberta, owned by G.G. Fowle
Improved method for the determination of methimazole in plasma by high-performance liquid chromatography
No full text- …
