1,720,989 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
PLHINT: A knowledge-driven computational approach based on the intermolecular H bond interactions at the protein-ligand interface from docking solutions
No full textThe tendency of docking scoring functions to generate crystal close conformations of ligands bound to protein structures face limitations in not reproducing the exact crystal intermolecular contacts in dock poses. Intermolecular H bond contacts enumerated at the protein-docked ligand interface can be used to train scoring models and improve virtual screening performance. There is a need to incorporate additional knowledge of protein-ligand H bond contacts in extension to crystal contacts from docking solutions within the reproducibility efficiency of the docking program. A computational approach PLHINT (Protein-ligand H bond interaction pattern) is presented here which extracts intermolecular H bond interactions from native-like docked ligand poses, transform into the scoring scheme and apply over the virtual screening results of database molecules. The basic premise of the PLHINT approach is to score the most observed H bond patterns with the high score to achieve high recovery rates. Tested on ten diverse DUD-E benchmark datasets, the approach has demonstrated better overall performance and ligand enrichment competency over virtual screening results generated by three genetic algorithm-based docking programs viz. AutoDock Vina, FIexAID and PLANTS. Furthermore, the approach has successfully recovered the poor and random virtual screening results with better enrichments. (C) 2017 Elsevier Inc. All rights reserved
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
RNA Processing Dysfunction in TDP-ALS
Full text linkBackground: RNA processing dysfunction has been implicated in the pathology of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), not only due to causative TDP-43 disease mutations (TDP-ALS), but further the characteristic mislocalisation of crucial RNA-binding protein TDP-43 regardless of genetic background. This implicates the importance of investigating the widespread TDP-43 dysfunction-mediated changes in RNA processing, and the need to identify differential gene expression and alternative splicing changes that may underlie neurodegenerative disease. Methods: Two mouse models of TDP-43 were investigated, each containing a single substitution within the coding region of the Tardbp gene: one mutation in the RNA binding domain (RBD), the other in the low complexity domain hotspot region for ALS-causative mutations. RNA sequencing was used to examine resulting differential gene expression and alternative splicing events, and integrated iCLIP analysis highlighted changes in RNA binding patterns. Results and discussion: We identified severe molecular dysregulation in both models. The RBD mutant displayed dose-dependent preferential exon inclusion, including the retention of cryptic exons. Alongside this was downregulation of long intron-containing genes, typically related to neuronal activity. These features, alongside other RNA processing changes, were similar to those resulting from TDP-43 loss, and thus indicated the RBD mutation to cause TDP-43 loss of function. Contrastingly, we found that the LCD mutation caused greater levels of exon skipping, including novel gain of TDP-43 function in splicing which resulted in mutant-specific ‘skiptic’ transcripts. A subset of these was then demonstrated to be conserved in a TDP-ALS mouse model, and further in human TDP-ALS patient settings. Importantly, this gain of function mouse model developed a neurodegenerative, ALS-like phenotype. This indicated that TDP-43 gain of function, even in the absence of loss of function effects, is sufficient to cause a neurodegenerative disease phenotype
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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