104,059 research outputs found
Siva's Classical Equation for Space Time and Matter
No full textABSTRACT There is a relation between mass 'm' of the body and its affect on space time defined for it at a radius'd' from the center of that body. It is assumed that the mass 'm' is inversely proportional to the square of radius'd'. The proportionality constant is not known. In the process of derivation of that constant, a new equation of space time and matter has been derived. Verification with Newton's law of gravitation, Newton's Gravitational Constant 'G' and Siva's Constant 'K' ,Classical Equation of space time and matter has been derived. An equation for space time density associated to a particular mass also has been derived. These equations will influence Black hole physics, Singularity problem of black holes, elementary particle physics and cosmology
Ochlodes siva subsp. yuchingkina Murayama & Shimonoya 1963
No full textOchlodes siva yuchingkina Murayama & Shimonoya, 1963 Tyô to G a 13(3): 53. Labels: “ Taiwan, Tsugitakayama (= Xueshan, in Chinese character)/ June 1961,” “ Ochlodes /siva/yuchingkina/ HOLOTYPE.” A male specimen was designated as the holotype by Murayama & Shimonoya (1962), and the specimen was retrieved in the Shimonoya collection (Figs. 7–9). Having examined the male genitalia, Chiba & Hsu (1989) indicated that yuchingkina is not a subspecies of siva Moore, 1878, but of bouddha Mabille, 1876. Subsequent publications follow this view (Chiba et al. 1992, Chiba & Tsukiyama 1996, Hsu 2013, Hsu et al. 2019). We regard yuchingkina as a subspecies of O. bouddha.Published as part of Chiba, Hideyuki, Tsukiyama, Hiroshi, Liang, Jia-Yuan, Wang, Shou-Ming, Shen, Zong-Yu & Hsu, Yu-Feng, 2020, The types of skippers described by Shu-Iti Murayama (Lepidoptera: Hesperiidae), pp. 280-290 in Zootaxa 4801 (2) on pages 281-282, DOI: 10.11646/zootaxa.4801.2.4, http://zenodo.org/record/399095
Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA
No full textTingting Li, Mengjiao Lv, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao TangDepartment of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, People’s Republic of ChinaPurpose: Plumbagin is thought to be a bioactive phytochemical drug and exerts an antitumor effect on various cancers. However, few studies focus on the antitumor activity of plumbagin on liver cancer. This study first investigated the antitumor activity of plumbagin on liver cancer and further investigated the molecular mechanism of its antitumor activity against hepatocellular carcinoma, both in vitro and in vivo.Methods: The antiproliferative activity of plumbagin was evaluated through CCK-8, EdU, and colony forming test. The cell cycle and apoptosis were then analyzed by flow cytometer. Western blot was used to detect the expression of apoptosis related protein, SIVA, and mTOR pathway. RNA-seq was performed to determine the gene expression profiles and overexpressed or knocked down SIVA to validate its role in plumbagin’s antitumor activity. Regarding animal experiment, a xenograft model in BALB/c nude mice was built using LM3-Luci cells. Then bioluminescence imaging and further immunohistochemistry were performed to study the antitumor activity and the expression of SIVA and mTOR in the plumbagin-treated group.Results: Plumbagin can inhibit proliferation and induce apoptosis of liver cancer cells in vitro. Further experiment demonstrated that plumbagin could inhibit the expression of SIVA and subsequently downregulate the mTOR signaling pathway, and upregulating the expression of SIVA will alleviate the antitumor activity of plumbagin on liver cancer, which confirmed the important role of the SIVA/mTOR signaling pathway in the antitumor activity of plumbagin. In vivo bioluminescence imaging showed a decreased signal in the plumbagin-treated group, and further immunohistochemistry demonstrated that plumbagin could inhibit the SIVA/mTOR signaling pathway in tumor tissues.Conclusion: Our promising results showed that plumbagin could inhibit proliferation and induce apoptosis of hepatic cancer through inhibiting the SIVA/mTOR signaling pathway for the first time, which indicated that plumbagin might be a good candidate against liver cancer.Keywords: hepatocellular carcinoma, plumbagin, antitumor, apoptosis, SIVA, mTO
Retinal microvascular diameter, a hypertension-related trait, in ECG-gated vs. non-gated images analyzed by IVAN and SIVA
No full textThe diameters of the retinal microvasculature reflect intermediate target organ damage and predict adverse health outcomes. In view of the pulsatility of the cerebral blood flow and refinement of software used for off-line analysis, we assessed the repeatability of retinal microvascular diameters in ECG-gated vs. non-gated images using nonmydriatic retinal photographs (Canon Cr-DGi visualization system) postprocessed by IVAN (Vasculomatic ala Nicola, version 1.1) or SIVA (Singapore I Vessel Assessment, version 3.6). Using these algorithms, we determined the central retinal arteriolar (CRAE) and venular (CRVE) equivalents and their ratio (arteriole-to-venule ratio (AVR)). The estimates of CRAE (mean, 158.5 μm), CRVE (222.5 μm) and AVR (0.71) in 10 volunteers were unaffected (P⩾0.059) by ECG gating. We assessed intragrader repeatability by the Bland and Altman approach in 30 participants with non-gated images and 30 with ECG-gated photographs. Repeatability, which was expressed as the percentage of near maximal variability (4-s.d. range), did not improve with ECG gating. Using SIVA, CRAE and CRVE were systematically larger (P⩽0.031), and the AVR estimates were similar (P⩾0.15) compared with IVAN. The differences (IVAN-SIVA) averaged -5.4 μm for CRAE, -3.9 μm for CRVE and -0.012 for AVR in the non-gated images and -3.3 μm, -6.9 μm and 0.006, respectively, in the ECG-gated photographs. In conclusion, ECG gating does not affect estimates of the retinal microvascular diameters or improve intragrader repeatability. SIVA yields slightly but significantly larger estimates of the retinal arteriolar and venular diameters. Combining historical readings analyzed by IVAN with more recent readings by SIVA is possible only for AVR and is not recommended for either CRAE or CRVE.sponsorship: The European Union (HEALTH-2011.2.4.2-2-EU-MASCARA, HEALTH-F7-305507 HOMAGE and the European Research Council Advanced Researcher Grant-2011-294713-EPLORE) and the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13 and G.088013) currently support the Studies Coordinating Centre in Leuven. We acknowledge the contribution of the nurses working at the examination centre (Linda Custers, Marie-Jeanne Jehoul, Daisy Thijs and Hanne Truyens) and the clerical staff at the Studies Coordinating Centre (Annick De Soete and Renilde Wolfs). (European Union|HEALTH-2011.2.4.2-2-EU-MASCARA, European Union|HEALTH-F7-305507 HOMAGE, European Union (European Research Council Advanced Researcher Grant)|2011-294713-EPLORE, Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium|G.0881.13, Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium|G.088013, Grants-in-Aid for Scientific Research|16K15359)status: Publishe
Shadow Economy in Slovenia: The Labour Approach
No full textThe all-around notorious shadow economy phenomenon is subject to constant reshaping, regarding both time and place, which results in a somewhat unclear definition. We use the following definition: all productive activities, whose output is legal, but is deliberately concealed from the authorities, usually for gaining financial benefits. Different methods of quantifying the size of the shadow economy have been developed. We focus on the labour approach, with Slovenia as the case study during the last decade. The importance of such an analysis lies in the ambiguous effects of the shadow economy and their policy implications. We found that the shadow economy that relates only to the unemployment discrepancies in Slovenia amounts on average to around 6 percent of the official economy, and tends to slightly decline over the most recent years. On the other hand, employment discrepancy and more detailed activity-level results give much higher values and even an increase in the shadow economy: on average around 20 percent in the studied period.shadow economy, indirect methods, employment discrepancies, labour approach
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
sj-jpg-3-tdo-10.1177_00494755231218773 - Supplemental material for Abdominal wall calcification in a peritoneal dialysis patient
No full textSupplemental material, sj-jpg-3-tdo-10.1177_00494755231218773 for Abdominal wall calcification in a peritoneal dialysis patient by M. Gurupriya, G. Anuhya, Mathini Sundarmurthy, Aishwarya P Lakshmi, R. Ram and V Siva Kumar in Tropical Doctor</p
sj-jpg-4-tdo-10.1177_00494755231218773 - Supplemental material for Abdominal wall calcification in a peritoneal dialysis patient
No full textSupplemental material, sj-jpg-4-tdo-10.1177_00494755231218773 for Abdominal wall calcification in a peritoneal dialysis patient by M. Gurupriya, G. Anuhya, Mathini Sundarmurthy, Aishwarya P Lakshmi, R. Ram and V Siva Kumar in Tropical Doctor</p
sj-jpg-2-tdo-10.1177_00494755231218773 - Supplemental material for Abdominal wall calcification in a peritoneal dialysis patient
No full textSupplemental material, sj-jpg-2-tdo-10.1177_00494755231218773 for Abdominal wall calcification in a peritoneal dialysis patient by M. Gurupriya, G. Anuhya, Mathini Sundarmurthy, Aishwarya P Lakshmi, R. Ram and V Siva Kumar in Tropical Doctor</p
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