1,721,210 research outputs found
Immunosuppressive regimens and outcomes of inflammatory bowel disease patients requiring kidney transplantation
No full textPatients with Patients with inflammatory bowel disease (IBD) can develop extra-renal complications and as a result, suffer from end stage renal failure requiring kidney transplantation (KT). A brief review of available literature revealed that IBD patients undergoing KT have shorter overall survival rates compared to their controls. Literature reporting steroid regimens and survival outcomes specific to IBD and post kidney transplant are scarce and these studies have small sample sizes thus making it difficult to draw accurate conclusions. Further research is required in the form of a randomized controlled study to clarify the effect and mechanism of steroid immunosuppression on the prognosis of renal transplant recipients and explore new treatment schemes.
Singh U, Singh B, Bellini MI. Immunosuppressive regimens and outcomes of inflammatory bowel disease patients requiring kidney transplantation. World J Transplant 2022; 12(2): 21-23 [PMID: 35211378 DOI: 10.5500/wjt.v12.i2.21]. A brief review of available literature revealed that IBD patients undergoing KT have shorter overall survival rates compared to their controls. Literature reporting steroid regimens and survival outcomes specific to IBD and post kidney transplant are scarce and these studies have small sample sizes thus making it difficult to draw accurate conclusions. Further research is required in the form of a randomized controlled study to clarify the effect and mechanism of steroid immunosuppression on the prognosis of renal transplant recipients and explore new treatment schemes
The role of RGD-rosette nanotubes in migration and apoptosis of bovine neutrophils
Full text linkBovine respiratory disease complex is the most common disease that causes sig-nificant economic loss, typically in feedlot cattle. Current treatment methods are focused on reducing inflammatory responses, control of airway reactivity and improvement of pulmonary functions without potential side effects. Neutrophils are the key contributors in acute lung inflammation. However, activated neutrophils live longer and cause exces-sive tissue damage upon migration into lungs. Therefore, modulation of their migration and lifespan are attractive approaches in treatment strategies of bovine respiratory dis-ease. Nanotechnology holds significant potential to design new compounds by our ability to manipulate at the nanoscale. Helical rosette nanotubes are a class of novel, biologi-cally inspired, water soluble and metal-free nanotubes. I used helical rosette nanotubes conjugated to arginine-glycine-aspartic acid (RGD-RNT) to study their effects on neu-trophil chemotaxis, cell signaling and apoptosis. Bovine neutrophils exposed to 5% RGD-RNT reduced their migration in response to fMLP (formyl-Methionyl-Leucyl-Phenylalanine), compared to the non-treated group (
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Expression and regulation of HSPB5 in the myometrium throughout pregnancy
Full text linkThe uterine smooth muscle or myometrium goes through phases of differentiation
during pregnancy to become a powerful contractile tissue at term. Small Heat Shock proteins
(sHSPs) are a family of ten small molecular weight proteins in mammals that are induced by
many physiological stressors such as uterine stretch. Some sHSPs act as chaperones, but also
others assist in cell death regulation, cytoskeleton rearrangements, and immune system
activation. We examined the spatio-temporal expression of HSPB5 protein throughout
gestation via immunoblot and immunofluorescence analysis, as well as the effect of uterine
distension on myometrial HSPB5 protein expression using unilaterally pregnant rat models.
HSPB5 protein expression significantly increased on day (d) 17 (p<0.05; vs all other timepoints)
and levels steadily decreased thereafter through to postpartum (PP). In contrast, serine-59
phosphorylated (pSer59) HSPB5 protein detection was significantly increased from d19 through
to PP (p<0.05). Both HSPB5 and pSer59-HSPB5 were detected in the cytoplasm of myocytes
within both uterine muscle layers mid- to late-pregnancy. In unilaterally pregnant rats, HSPB5
protein and pSer59-HSPB5 protein expression were significantly elevated in gravid uterine
horns at both d19 of gestation and d23 (labour) compared to non-gravid horns. The spatial
expression of total and pSer59-HSPB5 protein in a human myometrial cell line was examined by
immunofluorescence analysis. Total HSPB5 co-localized with α-smooth muscle actin and
pSer59-HSPB5 was co-localized with the focal adhesion protein kindlin-2 (KIN-2) and the
exosomal marker CD63. Therefore, HSPB5 is highly expressed during mid- to late-pregnancy
and expression appears to be regulated by uterine distension. HSPB5 may be involved in
regulating actin filament dynamics and could be secreted by exosomes
- …
