1,720,979 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pharmacoepidemiology and pharmacogenetics of serious adverse drug reactions
No full textSerious adverse drug reactions (SADRs) are one of the major causes of morbidity and mortality, posing significant burdens on patients as well as the health care system. Studies on SADRs are limited due to its rare occurrence. Large population-based databases may overcome this challenge by providing adequate samples to examine the pharmacoepidemiology of SADRs. On the other hand, genetic predisposition were observed in SADRs and pharmacogenetic tests have demonstrated its effectiveness to prevent SADRs. However, only few pharmacogenetic tests are available, urging the need for more pharmacogenetic studies.
This thesis particularly studied two SADRs – Steven-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) and drug-induced agranulocytosis (DIAG). The aim of the thesis is to investigate the epidemiology of SJS/TEN and DIAG in Hong Kong with the use of large population-based database, and determine the genetic susceptibility of these two SDARs in Chinese population. The epidemiological studies were conducted using data from the Hong Kong Clinical Data Analysis and Reporting System. The cases of TEN in two teaching hospitals were reviewed while all cases of DIAG in Hong Kong were evaluated. Genome-wide association studies were performed to investigate the pharmacogenetics of the SADRs.
The epidemiological studies reported a very low incidence rate but high mortality of TEN in Hong Kong, which is consistent with other populations. In contrary, the incidence rate and mortality of DIAG in Hong Kong were relatively lower than other populations. The two SADRs shared some common drug aetiology. Anticonvulsants, allopurinol and antibiotics are the most common implicated drugs in TEN, whereas antithyroid drugs, anticonvulsants and antibiotics are the most common in DIAG.
In the pharmacogenetic studies, no significant SNP was found in SJS/TEN but an interesting HLA class I marker, HLA-A*03:01, showed a significant association with SJS/TEN, suggesting a role of this allele in developing SJS/TEN. On the other hand, a significant SNP which is in complete linkage equilibrium with HLA-B*03:02:01 was found in carbimazole /methimazole-induced agranulocytosis. HLA-B*03:02:01 demonstrated potential clinical utility in preventing agranulocytosis.
The findings in this thesis broaden the understanding of the pharmacoepidemiology of SADRs in Hong Kong, which may help healthcare provider to direct future planning on the management of the two SADRs. The genetic markers discovered in this thesis provides insights in preventing the SADRs by using pharmacogenetic screening. Further studies are encouraged to confirm the findings. In addition, the thesis demonstrated a great value of using large healthcare database to study SADRs.published_or_final_versionPharmacology and PharmacyDoctoralDoctor of Philosoph
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
