15,897 research outputs found
Declaration of Intention for Antonio Franchihtti
No full textDeclaration of Intention to become a citizen of the United States, as filled out and signed by Antonio Franchitti. Applicant lists himself as a 47 year old farmer residing in Hammonton, New Jersey, born in Campombosso, Italy on 18 April 1870, who sailed on the US bound vessel Britania. Declaration submitted and sworn April 21, 1917
Subcutaneous Nadroparin Calcium in the Treatment of Recent Onset Retinal Vein Occlusion: A Pilot Study
No full textPurpose: Optimal management of retinal vein occlusion (RVO) is still a
matter of debate. The purpose of this pilot study was to investigate whether
nadroparin calcium may play some role in the treatment of recent onset (≤3 weeks'
duration) RVO. Methods: Twenty-four RVO patients were treated with subcutaneous
nadroparin calcium (200 I.U./kg/day) for 6 weeks. Best corrected visual acuity
(BCVA) and macular thickness in the affected eye were measured at baseline, and
after 3 and 6 months. Twenty-four RVO patients treated with oral pentoxifylline,
matched for age, gender, RVO type, eye involvement, and BCVA at presentation,
randomly selected from the RVO register, were used as controls. Results: Median
BCVAs at baseline, month 3, and month 6 were 20/70 (range: 20/1,000-20/20), 20/40
(range: 20/100-20/20), and 20/30 (range: 20/200-20/20) in cases and 20/70 (range:
20/1,000-20/20), 20/60 (range: 20/320-20/25), and 20/60 (range: 20/500-20/20) in
controls. Differences between groups were statistically significant at months 3
(P=0.025) and 6 (P=0.024). In the study group, the mean macular thickness was
510±207 μm at baseline, 384±198 μm after 3 months, and 313±170 μm after 6 months.
Differences between baseline and months 3 and 6 were statistically significant
(P=0.004 and P<0.001). Conclusions: Results suggest that nadroparin calcium might
become a potential candidate for the treatment of RVO. Larger trials are
necessary to confirm these preliminary findings
The role of educative thought in the life and work of Antonio Gramsci
No full textMany philosophers have propounded a vision of an improved society, what distinguishes Antonio Gramsci is his continuous effort to make it happen by understanding the process in order to put into practice. Gramsci's conviction about the importance of educative development came from both theory and experience. While there has been considerable examination of Gramsci's work in relation to the Prison Notebooks, this study will seek to address a lacuna in Gramsci scholarship. Using Gramsci's philological method, I analyse Gramsci's pre-prison activity; his pre-prison articles and letters, which, together with his letters from prison, formed part of his educative mission. This educative process was necessary, in order to construct a new party which would develop a collective will, collaboratively, with the masses.In this study therefore, I explore the contexts and formative experiences of the first part of his life together with the intellectual sources from which Gramsci developed his later theories, making central hitherto underemphasised connections between them which informed his writing and ideas. I intend to illustrate that Gramsci's underlying purpose in his writing, and political activity, was not only practical, on how to create a new socialist ruling class, but also educative in forming the mindset and values of his comrades. So that in addition to outlining his vision of a new order, he implicitly guided or explicitly explained the processes by which the necessary changes in social relations and moral climate could be made in order to achieve it. Each person had to engage with the values of the new order so that each could contribute to the construction of a new robust state. It was essential to build a hegemony at the most profound level, one which was dependent on collective understandings and a collective will
Investigating the Association Between HERV-K Autoantibodies and Neurodegeneration in Amyotrophic Lateral Sclerosis: A Molecular and Clinical Approach
No full textAmyotrophic lateral sclerosis (ALS), is a devastating neurodegenerative disease that affects about 400,000 people worldwide. Despite decades of intensive research, the cause of ALS remains widely unknown. Several studies documented the connection between Human Endogenous Retrovirus K (HERV-K) and the development of ALS.
Given the recent findings and emerging scientific evidence that reinforces this correlation, the purpose of this study is to investigate the relationship between the autoantibodies (AAbs) against the HERV-K envelope and the pathogenesis and progression of ALS. Our study gave particular attention to the humoral response toward the most immunogenic epitopes of the envelope protein.
Additionally, since microRNAs (miRNAs) play a crucial role in regulating gene expression, our study investigated their potential involvement in ALS. Although miRNAs dysregulation has been previously associated with ALS, understanding of its potential impact on HERV-K transcriptional levels is still limited. By delving deeper into these topics, our project aimed to contribute to the development of new strategies for the prevention, diagnosis, and treatment of ALS.
During my doctoral research, I had the opportunity to work on a project pertaining to the role of the humoral response against NL-63, HERVs, and Interferons in SARS-CoV-2 patients. The study was conducted during the outbreak of the SARS-CoV-2 pandemic. Its purpose was to better understand the reasons for the extremely diverse immune responses observed in the population through the detection of antibodies (Abs) that could cross-react with SARS-CoV-2 antigens or predict a more severe form of the disease.Amyotrophic lateral sclerosis (ALS), is a devastating neurodegenerative disease that affects about 400,000 people worldwide. Despite decades of intensive research, the cause of ALS remains widely unknown. Several studies documented the connection between Human Endogenous Retrovirus K (HERV-K) and the development of ALS.
Given the recent findings and emerging scientific evidence that reinforces this correlation, the purpose of this study is to investigate the relationship between the autoantibodies (AAbs) against the HERV-K envelope and the pathogenesis and progression of ALS. Our study gave particular attention to the humoral response toward the most immunogenic epitopes of the envelope protein.
Additionally, since microRNAs (miRNAs) play a crucial role in regulating gene expression, our study investigated their potential involvement in ALS. Although miRNAs dysregulation has been previously associated with ALS, understanding of its potential impact on HERV-K transcriptional levels is still limited. By delving deeper into these topics, our project aimed to contribute to the development of new strategies for the prevention, diagnosis, and treatment of ALS.
During my doctoral research, I had the opportunity to work on a project pertaining to the role of the humoral response against NL-63, HERVs, and Interferons in SARS-CoV-2 patients. The study was conducted during the outbreak of the SARS-CoV-2 pandemic. Its purpose was to better understand the reasons for the extremely diverse immune responses observed in the population through the detection of antibodies (Abs) that could cross-react with SARS-CoV-2 antigens or predict a more severe form of the disease
Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells
No full textMicrogravity (μg) during spaceflight affects cellular and molecular functions of both human cells and microbial pathogens, influencing viral replication and the host immune system. This study aimed to investigate the effects of simulated μg on Herpes Simplex Virus-1 (HSV-1) replication, host pro-inflammatory cytokine, and human endogenous retrovirus (HERV) activation in human neuroblastoma SH-SY5Y cells. Our results show that μg has a negative impact on HSV-1 replication, leading to significantly reduced viral titers and lower expression levels of HSV-1 early genes (ICP0, ICP4, and ICP27) compared to 1 gravity (1 g) conditions. Interestingly, despite lower viral titers and HSV-1 gene expressions under μg condition, we observed higher levels of HERVs and pro-inflammatory cytokine gene expression. In addition, there was a significant correlation between HSV-1 immediate-early genes with HERVs and pro-inflammatory cytokine gene expression, with stronger correlations observed under μg conditions. Taken together, μg reduces HSV-1 replication and increases host pro-inflammatory and HERVs gene expression, which demands further investigation for human health protection in space
Upregulation of microRNAs correlates with downregulation of HERV-K expression in Parkinson’s disease
No full textHuman endogenous retroviruses (HERVs) involvement in neurological diseases has been extensively documented, although the etiology of HERV reactivation remains unclear. MicroRNAs represent one of the potential regulatory mechanisms of HERV reactivation. We identified fourteen microRNAs predicted to bind the HERV-K transcript, and subsequently analyzed for their gene expression levels alongside those of HERV-K. We documented an increased expression of four microRNAs in patients with Parkinson’s disease compared to healthy controls, which correlated with a downregulation of HERV-K transcripts. We hypothesize that specific microRNAs may bind to HERV-K transcripts, leading to its downregulation
Edna Ferber in St. Anthony Hotel, San Antonio, Tex., 1948
No full text''Ferber's novel, Giant, set on a fictitious south Texas ranch, was published in 1952.''''Edna Ferber was in San Antonio on Saturday for a search of the surrounding ranch country for material and characters for a new book. The author of Show boat was registered at the St. Anthony Hotel.'
3D printed lattices as an activation and expansion platform for T cell therapy
No full textLink to a related website: https://eprints.qut.edu.au/107857/1/107587.pdf, Open Access via UnpaywallAbstract not availableBahman Delalat, Frances Harding, Batjargal Gundsambuu, Elena M. De-Juan-Pardo, Felix M. Wunner, Marie-Luise Wille, Marek Jasieniak, Kristen A.L. Malatesta, Hans J. Griesser, Antonio Simula, Dietmar W. Hutmacher, Nicolas H. Voelcker, Simon C. Barr
Desenganos mysticos para as almas detidas ou enganadas no caminho da perfeiçao... : seu author na lingua hespanhola... Fr. Antonio Arbiol...
No full textSign.: [parágrafo]-2[parágrafo]8, 3[parágrafo]2, A-Z8, 2A-2X8, 2Z1. -- Texto a dos col. -- Port. con viñeta tip. -- Falto de p. 305-350.Sainz Rodrígue
Antonio Rosminis Principles of moral science: translation of an Italian philosophical work to Portuguese
No full textEste trabalho se compõe de duas partes. Primeiramente, um estudo introdutório sobre o autor, Antonio Rosmini, sobre sua obra filosófica e, mais especificamente, sobre o livro Principi della scienza morale, que, na segunda parte, traduzimos para o português. Na introdução, expomos brevemente o sistema filosófico rosminiano e o contextualizamos no âmbito histórico-filosófico. Além disso, apresentamos o percurso por nós desenvolvido para obter uma tradução filologicamente correta do texto original, incluindo um breve glossário dos termos filosóficos empregados pelo autor.This work is composed of two parts. Firstly, there is an introductoty study on the author, Antonio Rosmini, on his phylosophical system and, more specifically, on the book Principi della scienza morale, which we have translated to Portuguese, in the second part. In the introduction, we expose briefly the rosminian phylosofical system and we place it in its historical-phylosofical context. Furthermore, we show the path weve followed to reach a phylologically correct translation from the original text, including a brief glossary of phylosophical terms employed by the author
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