489 research outputs found
Novel and flexible approach to access the open ocean: Uses of sailing research vessel Lady Amber during SPURS-2.
No full text© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Rainville, L., Centurioni, L. R., Asher, W. E., Clayson, C. A., Drushka, K., Edson, J. B., Hodges, B. A., Hermann, V., Farrar, J. T., Schanze, J. J., & Shcherbina, A. Y. Novel and flexible approach to access the open ocean: Uses of sailing research vessel Lady Amber during SPURS-2. Oceanography, 32(2), (2019): 116-121, doi: 10.5670/oceanog.2019.219.SPURS-2 (Salinity Processes in the Upper-ocean Regional Study 2) used the schooner Lady Amber, a small sailing research vessel, to deploy, service, maintain, and recover a variety of oceanographic and meteorological instruments in the eastern Pacific Ocean. Low operational costs allowed us to frequently deploy floats and drifters to collect data necessary for resolving the regional circulation of the eastern tropical Pacific. The small charter gave us the opportunity to deploy drifters in locations chosen according to current conditions, to recover and deploy various autonomous instruments in a targeted and adaptive manner, and to collect additional near-surface and atmospheric measurements in the remote SPURS-2 region.Tragically, Lady Amber Captain Peter Flanagan passed away on March 15, 2016, after the initial transit. This was a big loss for his friends and crew—his enthusiasm will be sorely missed. We acknowledge the owner and crew of Lady Amber for remaining
committed to the SPURS-2 work. This work would not have been possible without Captain Arran Flanagan and Captain Ryan Struthers and the capable crew of Lady Amber. This project was supported by NASA grant NNX15AT40G. We also acknowledge
the contribution of Justin Burnett, Jesse Dosher, and Aaron Paget to the design and installation of the LAPS, and the support and cooperation from all the SPURS-2 PIs
Hauntings of Publication Deaths, Possibilities for Our Academic Present
No full textIn this paper, we use a feminist dialogue to query publication deaths that haunt us. We ruminate on respective past publications that remain unread and uncited, despite encapsulating defining events in our development as scholars. For Author Kaye Hare this was an affective narrative that troubled a seemingly ideal moment of public scholarship; for Author Amber Moore, this was a hard-fought analysis of precarious intersectional feminist resistance in popular culture. Inspired by the horror-film genre “spectral incognizance,” we methodologically deploy a multivocal dialogical structure based on multiple revisitings that attenuate anxieties of metaphorical publication death, before revealing that this death is imminent. Through re-examining our past works, this project invites consideration of how our publications’ f(l)ailings can draw out a particular haunting temporality that holds the present open to provocative questions that are difficult to pose and sustain within current institutional, academic processes
Response and Adaptation of Escherichia coli to Suppression of the Amber Stop Codon
No full textSome extant organisms reassign the amber stop codon to a sense codon through evolution, and suppression of the amber codon with engineered tRNAs has been exploited to expand the genetic code for incorporating non-canonical amino acids (ncAAs) in live systems. However, it is unclear how the host cells respond and adapt to such amber suppression. Herein we suppressed the amber codon in Escherichia coli with an orthogonal tRNA/synthetase pair and cultured the cells under such a pressure for about 500 generations. We discovered that E. coli quickly counteracted the suppression with transposon insertion to inactivate the orthogonal synthetase. Persistent amber suppression evading transposon inactivation led to global proteomic changes with a notable up-regulation of a previously uncharacterized protein (YdiI) for which we identified an unexpected function of expelling plasmids. These results should be valuable for understanding codon reassignment in genetic code evolution and for improving the efficiency of ncAA incorporation.Biochemistry & Molecular BiologyChemistry, MedicinalSCI(E)[email protected],SI1744-17491
NMDA Receptor Modulators in the Treatment of Drug Addiction
No full textGlutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function
Reading acts of narrative appropriation: four instances of fraudulent memoir
No full textPhDThis thesis examines acts of narrative appropriation, the telling of purportedly‘authentic’ life stories by those for whom the stories are not theirs to tell. This
misuse or subversion of genre - the discipline of historical writing and the category
of autobiography - becomes a means for cultural, social and political dissimulation,
and the analysis focuses both on the act: the event, trespass, or ‘theft’ of another’s
life story, and on the cultural meaning that this event reveals. These narrative acts
are approached theoretically through discussions of what it means to be an author, a
reader, and through the consideration of literary and social genre, category and form.
In exploring identities at particular risk of appropriation, this thesis shows how
fraudulent appropriated narratives affect our reading of the world, and in turn
influence our perception of already marginalized social groups. My primary
examples include prostitution ‘narratives’, Native North American ‘memoir,’ and
fraudulent Holocaust survivor ‘testimony,’ with each text providing decoded
evidence of ‘genre-bending’ exhibiting a social and political intent. These works
seek to be read as authentic personal narratives, as autobiography, and that is how
they have been presented to the reader. However, they are imposters – fictional tales
desiring the elevated status of historical authenticity and willing to bend the rules
and contracts of genre to achieve their end. Here the appearance of authenticity is
achieved through the use of cultural and social ‘myth,’ or perceptions of cultural
identity, and as such its fraudulent construction is first and foremost a social act,
with a social and economic motivation. As this thesis concludes, these texts are
most successful when their own political and social ideologies echo and confirm that
of the readership; when their subjects, the fraudulent ‘I’ at the center of the text is
also a performative elaboration of cultural belief
Neonatal domoic acid abolishes latent inhibition in male but not female rats and has differential interactions with social isolation.
No full textDeficits in attention have long been identified as a core feature in schizophrenia and related neuropsychiatric disorders. We have investigated the combined effects of neonatal treatment with domoic acid (DOM) and social isolation rearing (both putative animal models of schizophrenia) on latent inhibition (LI), a measure of attentional processing. Daily subcutaneous injections of 20 μg/kg DOM or saline were administered to rat pups from postnatal days (PND) 8-14. After weaning, rats were housed either alone or in groups of 4 until LI was assessed at PND 110 using a lick-suppression conditional emotional response paradigm. Neonatal treatment with DOM abolished LI behaviour in adult male rats regardless of housing condition when tested 48 h after conditioning, but this effect was not observed in female rats. Social isolation rearing also reduced LI in male rats, but not to the same extent as DOM. When tested again one week later, single-housed males treated with DOM displayed significant LI whereas saline treated or group-housed DOM males did not. No significant differences were found with females 1 week later. We conclude that neonatal DOM and social isolation both impair attentional processing in young adult male, but not female, rats although the mechanisms by which this occurs appear to be different.journal articleresearch support, non-u.s. gov't2014 Aug 222014 06 19importe
Assessing Impacts of Drought on Herpetofauna Through Repeated Surveys and Morphometric Comparisons
No full textDecreases in overall abundance, diversity and body condition of amphibians and reptiles have been linked to global climate change. One manifestation of climate change is more extreme weather patterns. Extended droughts and intense drought conditions are cyclical events for Texas and the Southwest. A recent exceptional drought in central Texas not only directly diminished aquatic and semi-aquatic habitats but also exacerbated other biotic stressors. I repeated relative abundance and diversity surveys conducted in 2004 at a 9-ha ranch in Guadalupe County, Texas, in spring 2009 coincidently with an intense drought. My relative abundance and diversity analyses sought to determine if the drought reduced abundance and diversity of herpetofauna. Additionally, data from the Bastrop County Houston toad (Bufo houstonensis) database combined with Houston toad captures from Griffith League Ranch (GLR) in Bastrop County in 2009 were analyzed for changes in body condition. The results provide new information for the assessment of drought impacts in this group of vertebrates and analytical issues associated with categorizing drought conditions and discriminating among years for drought effects.Biolog
Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders.
No full textInvestigation into the causes underlying the rapid, global amphibian decline provides critical insight into the effects of changing ecosystems. Hypothesized and confirmed links between amphibian declines, disease, and environmental changes are increasingly represented in published literature. However, there are few long-term amphibian studies that include data on population size, abnormality/injury rates, disease, and habitat variables to adequately assess changes through time. We cultured and identified microorganisms isolated from abnormal/injured and repressed tissue regeneration sites of the endangered Ozark Hellbender, Cryptobranchus alleganiensis bishopi, to discover potential causative agents responsible for their significant decline in health and population. This organism and our study site were chosen because the population and habitat of C. a. bishopi have been intensively studied from 1969-2009, and the abnormality/injury rate and apparent lack of regeneration were established. Although many bacterial and fungal isolates recovered were common environmental organisms, several opportunistic pathogens were identified in association with only the injured tissues of C.a. bishopi. Bacterial isolates included Aeromonas hydrophila, a known amphibian pathogen, Granulicetella adiacens, Gordonai terrae, Stenotrophomonas maltophilia, Aerococcus viridans, Streptococcus pneumoniae and a variety of Pseudomonads, including Pseudomonas aeruginosa, P. stutzeri, and P. alcaligenes. Fungal isolates included species in the genera Penicillium, Acremonium, Cladosporium, Curvularia, Fusarium, Streptomycetes, and the Class Hyphomycetes. Many of the opportunistic pathogens identified are known to form biofilms. Lack of isolation of the same organism from all wounds suggests that the etiological agent responsible for the damage to C. a. bishopi may not be a single organism. To our knowledge, this is the first study to profile the external microbial consortia cultured from a Cryptobranchid salamander. The incidence of abnormalities/injury and retarded regeneration in C. a. bishopi may have many contributing factors including disease and habitat degradation. Results from this study may provide insight into other amphibian population declines
UA1C11/105/36 Phi Mu Composite
No full textPhi Mu Sorority top row l to r: Abby Blandford, Chelsea Reed, Shelby Nitzken, Morgan Temple, Atalie Maxwell, Brandi Ratterman, Allison Teta, Makenze Evans, Brenna Duncan, Natalie Mullins, Sarah Weber, Chelsea Scherer, Elizabeth Barnard. 2nd row l to r: Maggie Ballard, Katie Basham, Madison Beach, Haley Cummins, Mary Johnson, Ashley Kelly, Elizabeth Pickens, Katie Pollard. 3rd row l to r: Emily Pribble, Christina Simpson, Emiley Smiley, Christina Abney, Chelsea Barrett, Sarah Browning, Hanna DeSpain, Laura Ellis, Jasmine Finta-Obee, Michelle Fry. 4th row l to r: Jordan Morton, Caitlin Muller, Laura Niewoehner, Lauren Pollock, Shelby Shelton, Katie Snedegar, Jorden Stallings, Allison Steen, Keely Stout, Hailey Strickland, Emily Taylor, Amber Turner, Hannah Williams, Sara Colvin, Leah Doster. 5th row l to r: Ashley Manley, Amanda Thomas, Jennifer Zinger, Meghan Baumgartner, Allison Diehl, Kylie Foushee, Cassidy Haley, Leah Hotchkiss, Alyson Manley, Claudia Nunez, Tori Royster, Kristin Searcy, Lindsay Sexton, Shelby Steblein, Amber Stephenson. 6th row l to r: Ashton Wheeles, Erin Charles, Hannah Cope, Dana Echert, Alexis Linn, Mary Music, Stacey Riggle, Sydney Anderson, Dalice Ballou, Laura Banks, Caitlin Belcher, Frankie Boyette, Morgan Buttrey, Gabriella Crofford, Magean Davis. 7th row l to r: Frankie DeVita, Sarah Dyar, Emily Gerard, Gretchen Gessner, Ashlee Gregory, Lauren Haynes, Emily Hightower, Hanna Jobes, Kelley King, Isabelle LaBarge, Abby Lancaster, Katlyn Logsdon, Brooke McClain, Carsen Murt, Samantha Reams. 8th row l to r: Chloe Rhodes, Haley Rogers, Payton Taylor, Nicole Thieneman, Sarah Tomlin, Caroline Alexander, Claire Arant, Kristina Johnson, Hanna Philpot, Mallory Runnels, Oliva Sheaffer, Margaret Shelton
Sich in die eigene Tasche lügen? Selbsttäuschung als irrationales Projekt
No full textThis article for the PHILOKLES Journal for Popular Philosophy surveys a few common theoretical approaches to the phenomenon of self-deception before putting forward a thus far relatively unexplored intentionalist option, namely what the author calls the "project model of self-deception". On this model, self-deception is understood as a dynamic, diachronic activity, aimed at the preservation of a certain self-image, to which an agent is implicitly committed. The author shows how this model can make subjects responsible for their self-deceptions without running straightforwardly into the so-called "paradoxes" of self-deception
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