2,630 research outputs found
C.A. Parker's Store
No full textPhotograph - A dog team and a loaded sled on Strathcona Street in front of C.A. Parker's store, Athabasca, Albert
Eigen schuld van de architect
No full textRede, uitgesproken bij het afscheid als buitengewoon hoogleraar in het bouw- en woning recht aan de Technische Hogeschool Delft op vrijdag 21 februari 1986 door prof.mr C.A. Adriaansens.Architectur
C.A. McGill, March 23, 1918
No full textPortrait of C.A. McGill. Written on verso: With love from C.A. McGill Monrovia, Liberia, March 23rd, 1918.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the National Endowment for Humanities - Humanities Collections and Reference Resources Implementation Project Grant in supporting the processing and digitization of a number of its major archival collections as part of the project: Spreading the Word: Expanding Access to African American Religious Archival Collections at the Atlanta University Center Robert W. Woodruff Library.</em
Erratum: Future temperature extremes will be more harmful: A new critical factor for improved forecasts (Int. J. Environ. Res. Public Health 2019, 16 (20), 4015)
No full textThe authors would like to correct the names and surnames of both authors of their previous paper [1] as follows: Costas A. Varotsos1,2,* and Yuri A. Mazei2 Therefore, to cite this paper please use the correct reference as follows: Varotsos, C.A.; Mazei,Y.A. Future Temperature Extremes Will Be More Harmful: A New Critical Factor for Improved Forecasts. Int. J. Environ. Res. Public Health 2019, 16 (20), 4015. © 2020 by the author. Licensee MDPI, Basel, Switzerland
Skeleton-based design and simulation flow for Computation-in-Memory architectures
No full textMemristor-based Computation-in-Memory is one of the emerging architectures proposed to deal with Big Data problems. The design of such architectures requires a radically new automatic design flow because the memristor is a passive device that uses resistance to encode its logic value. This paper proposes a design flow for mapping parallel algorithms on the CIM architecture. Algorithms with similar data flow graphs can be mapped on the crossbar using the same template containing scheduling, placement, and routing information; this template is named skeleton. By configuring such a skeleton with different pre-designed circuits, we can build CIM implementations of the corresponding algorithms in that class. This approach does not only map an algorithm on a memristor crossbar, but also gives an estimation of its performance, area, and energy consumption. It also supports user-defined constraints and parallel SystemC simulation. Experimental results demonstrate the feasibility and the potential of the approach.Accepted Author ManuscriptComputer EngineeringQuantum & Computer EngineeringFTQC/Bertels La
Thoughts about cancer stem cells in solid tumors
No full textCancer chemotherapy efficacy is frequently impaired by either intrinsic or acquired tumor resistance. A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue cells. In recent years, the cancer stem cell (CSC) theory has changed the classical view of tumor growth and therefore the therapeutic perspective. Overcoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. On the other hand, the identification of CSCs in vivo and in vitro relies on specific surface markers that should allow the sorting cancer cells into phenotypically distinct subpopulations. In the present review, recent papers published on CSCs in solid tumors (breast, prostate, brain and melanoma) are discussed, highlighting critical points such as the choice of markers to sort CSCs and mouse models to demonstrate that CSCs are able to replicate the original tumor. A discussion of the possible role of aldehyde dehydrogenase and CXCR6 biomarkers as signaling molecules in CSCs and normal stem cells is also discussed. The author believes that efforts have to be made to investigate the functional and biological properties of putative CSCs in cancer. Developing diagnostic/prognostic tools to follow cancer development is also a challenge. In this connection it would be useful to develop a multidisciplinary approach combining mathematics, physics and biology which merges experimental approaches and theory. Biological models alone are probably unable to resolve the problem completely
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Long-term movement patterns of a coral reef predator
No full textLong-term monitoring is required to fully define periodicity and patterns in animal movement. This is particularly relevant for defining what factors are driving the presence, location, and movements of individuals. The long-term movement and space use patterns of grey reef sharks, Carcharhinus amblyrhynchos, were examined on a whole of reef scale in the southern Great Barrier Reef to define whether movement and activity space varied through time. Twenty-nine C. amblyrhynchos were tracked for over 2 years to define movement patterns. All individuals showed high residency within the study site, but also had high roaming indices. This indicated that individuals remained in the region and used all of the monitored habitat (i.e., the entire reef perimeter). Use of space was consistent through time with high reuse of areas most of the year. Therefore, individuals maintained discrete home ranges, but undertook broader movements around the reef at times. Mature males showed greatest variation in movement with larger activity spaces and movement into new regions during the mating season (August-September). Depth use patterns also differed, suggesting behaviour or resource requirements varied between sexes. Examination of the long-term, reef-scale movements of C. amblyrhynchos has revealed that reproductive activity may play a key role in space use and activity patterns. It was unclear whether mating behaviour or an increased need for food to sustain reproductive activity and development played a greater role in these patterns. Reef shark movement patterns are becoming more clearly defined, but research is still required to fully understand the biological drivers for the observed patterns
Using acoustic monitoring to evaluate MPAs for shark nursery areas: the importance of long-term data
No full textThe presence and movements of a population of young blacktip sharks (Carcharhinus limbatus) was monitored via a series of acoustic hydrophones over a period of three years to examine their use of a coastal nursery area. Data from this project were used to investigate the efficacy of hypothetical marine protected areas for this population. Small and large reserve designs were used to determine which would provide better protection for this population. The small reserve provided consistent levels of protection across years with sharks receiving good protection early in the summer season, but with declining protection thereafter. The large reserve provided less consistent levels of protection across years, but provided protection for a greater portion of time than the small reserve. Excursions from the small reserve were high early in the season and declined as sharks used this region less through the later portion of the summer. Excursions from the large reserve did not show any consistent pattern, but were also high early in the season and decreased through time as sharks used less of the reserve area. These results, coupled with previously calculated mortality estimates, revealed that the large reserve provided better protection for young sharks during their most vulnerable period within the nursery. We suggest that time-area closures for nursery populations of highly mobile shark species may be of value. Results of this study also show that long-term data may be critical to effective reserve design and placement, and assessment of reserve efficacy
Science or slaughter: need for lethal sampling of sharks
No full textGeneral consensus among scientists, commercial interests, and the public regarding the status of shark populations is leading to an increasing need for the scientific community to provide information to help guide effective management and conservation actions. Experience from other marine vertebrate taxa suggests that public, political, and media pressures will play an increasingly important part in setting research, management, and conservation priorities. We examined the potential implications of nonscientific influences on shark research. In particular,we considered whether lethal research sampling of sharks is justified. Although lethal sampling comes at a cost to a population, especially for threatened species, the conservation benefits
from well-designed studies provide essential data that cannot be collected currently in any other way. Methods
that enable nonlethal collection of life-history data on sharks are being developed (e.g., use of blood samples to
detect maturity), but in the near future they will not provide widespread or significant benefits. Development
of these techniques needs to continue, as does the way in which scientists coordinate their use of material
collected during lethal sampling. For almost half of the known shark species there are insufficient data to
determine their population status; thus, there is an ongoing need for further collection of scientific data to
ensure all shark populations have a future. Shark populations will benefit most when decisions about the use
of lethal sampling are made on the basis of scientific evidence that is free from individual, political, public,
and media pressures
- …
