7,535 research outputs found
Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective
No full textMulti-channel services for click and mortars: Development of a design method
No full textThe rise of Internet commerce led to multiple predictions of disintermediation and the decline of physical shopping. However, a "click and mortar" approach, which combines online, offline and telephone contact, has added value for customers and for supplier profitability, as recent research confirms. Our research objective was to help organizations design Internet services for a multi-channel context. We compared several existing (service) design methods, and combined them into the "Multi-channel QFD" (MuCh-QFD) method, which was tested for effectiveness in a structured field experiment. The method consists of a standardized intake and a service definition session of four hours with multiple stakeholders. We developed a control group session with an alternative design approach: "Fundamental Engineering" (FE). The performance of both sessions is compared on: customer orientation, channel coherence, channel synergy, competitive positioning, process progression, process focus and stakeholder communication. The main conclusion is that MuCh-QFD sessions perform significantly better than FE sessions on customer orientation (p<0.001), channel coherence (p=0.01) and communication between stakeholder perspectives like sales, service, marketing, ICT and processes (p<0.001). The value of MuCh-QFD is: starting from customer priorities, explicitly connecting them to service functionality priorities, incorporating multi-channel customer needs and functions, connecting stakeholder perspectives and aiding the communication of design decisions after sessions. Finally, the field experiment illustrates a promising paradigm for developing and testing design methods via standardized half-day sessions.Technology, Policy and Managemen
Dialect Perception and Language Development in Pasil
Get PDFThe Kalinga province in the Cordillera Region of the Philippines is known for its high ethnolinguistic diversity. These ethnoliguistic groups are very cohesive and have very strong sense of identity. With language development happening in different parts of the province, there was a need to revisit one of its municipalities, Pasil, to find out its language development need. In 2010 and in 2014, a sociolinguistic survey was conducted in Pasil to determine the (1) language vitality of Pinasil* , (2) extensibility of materials from Kalinga Lubuagan [knb], a related variety (Gieser and Busenitz 1974; Lewis, Simons, and Fennig 2016), and (3) possibility of language development in Pasil, if Kalinga Lubuagan materials are not acceptable. This paper presents the results of the dialect perception study aspect of the language survey conducted in 8 Pasil villages, representing its seven sub-tribes. In addition, data gathered from the village of Balbalasang** in Balbalan municipality was also included in the analysis. There were several instruments used in this research but this paper will focus on the data gathered using a participatory tool called Dialect Mapping (Hasselbring 2008). This tool was used to elicit the speakers’ perception of linguistic similarity, language use, level of understanding and comprehension of the different varieties spoken in their community, and materials extensibility. The study found that the use of written Kalinga Lubuagan materials could not be extended to Pasil. Though there may be high intelligibility between the two, Lubuagan is perceived to be different so it has very low acceptability. On the question of which Pinasil variety should be used as written standard, all villages made their spoken variety as their first choice, of course. However, six out of eight villages made the Guinaang variety as one of their top choices. Further, this study affirms that the issue of identity is not only more significant in the speakers’ acceptance of materials than intelligibility, but also in the sustainability of language development efforts in general. References: Busenitz, Robert, Richard Gieser, and Dave Ohlson. 1974. “Kalinga Survey Report”. Manila, Philippines. Hasselbring, Sue. 2008. Steps for Nine Participatory Tools for Language Programs. SIL International. Lewis, M. Paul, Gary F. Simons, and Charles D. Fennig, ed. 2016. Ethnologue:Languages of the World. 19th ed. Dallas, Texas: SIL International. http://www.ethnologue.com. * Pinasil is a toponym for the language spoken in Pasil Municipality. ** Also listed as a dialect of Kalinga Lubuagan [knb] like the varieties spoken in Pasil
Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations
No full textFe-Cluster Pushing Electrons to N‑Doped Graphitic Layers with Fe<sub>3</sub>C(Fe) Hybrid Nanostructure to Enhance O<sub>2</sub> Reduction Catalysis of Zn-Air Batteries
No full textNon-noble metal catalysts with catalytic
activity toward oxygen reduction reaction (ORR) comparable or even
superior to that of Pt/C are extremely important for the wide application
of metal–air batteries and fuel cells. Here, we develop a simple
and controllable strategy to synthesize Fe-cluster embedded in Fe3C nanoparticles (designated as Fe3C(Fe)) encased
in nitrogen-doped graphitic layers (NDGLs) with graphitic shells as
a novel hybrid nanostructure as an effective ORR catalyst by directly
pyrolyzing a mixture of Prussian blue (PB) and glucose. The pyrolysis
temperature was found to be the key parameter for obtaining a stable
Fe3C(Fe)@NDGL core–shell nanostructure with an optimized
content of nitrogen. The optimized Fe3C(Fe)@NDGL catalyst
showed high catalytic performance of ORR comparable to that of the
Pt/C (20 wt %) catalyst and better stability than that of the Pt/C
catalyst in alkaline electrolyte. According to the experimental results
and first principle calculation, the high activity of the Fe3C(Fe)@NDGL catalyst can be ascribed to the synergistic effect of
an adequate content of nitrogen doping in graphitic carbon shells
and Fe-cluster pushing electrons to NDGL. A zinc–air battery
utilizing the Fe3C(Fe)@NDGL catalyst demonstrated a maximum
power density of 186 mW cm–2, which is slightly
higher than that of a zinc–air battery utilizing the commercial
Pt/C catalyst (167 mW cm–2), mostly because of the
large surface area of the N-doped graphitic carbon shells. Theoretical
calculation verified that O2 molecules can spontaneously
adsorb on both pristine and nitrogen doped graphene surfaces and then
quickly diffuse to the catalytically active nitrogen sites. Our catalyst
can potentially become a promising replacement for Pt catalysts in
metal-air batteries and fuel cells
Precipitation of supersaturated solute in H ion irradiated Fe-Au and Fe-Au-W alloys studied by positron annihilation spectroscopy
No full textThe effect of thermal aging of homogenized Fe-Au and Fe-Au-W alloys, irradiated at room temperature with hydrogen ions, was studied for an aging treatment at 300 °C for aging times up to 100 h. The aging behavior of the Fe-based alloys is compared to the results for pure Fe. The precipitation behavior of Au-rich and W-rich precipitates and its correlation to the H+ irradiation-induced defects is investigated by variable energy positron annihilation spectroscopy (VEPAS). The formation of open-volume defects after irradiation is monitored by an increase in the S parameter, while the recovery of the vacancy-like defects and the formation of precipitates are signalled by an increase in the W parameter. Au-rich precipitation continuously develops during long-term aging, as indicated by the increase in the W parameter. The change of the W parameter in the Fe-Au-W alloy is not only due to the effect of solute W on the Au precipitates, but also because of the interface of W-rich Laves phase with matrix.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Novel Aerospace MaterialsRST/Fundamental Aspects of Materials and Energ
General Sheman's Visit to Santa Fe
No full textComments on an article by the Jesuits, concerning General Sherman's visit to Santa Fe, from Revista Catolica, October 12, 1878. Fight against the Jesuits, Catholic Church, comment on Bishop Lamy, St. Francis Cathedral, Protestants. Translated from Spanish to English. No sure of author? Document in English, 1 pp/fr, two pages per frame
World Allergy Organization survey on global availability of essentials for the assessment and management of anaphylaxis by allergy-immunology specialists in health care settings
No full textEarly atopic disease and early childhood immunization--is there a link?
No full textBACKGROUND:
There are frequent concerns about early immunizations among the parents of children at heightened risk for atopy. The study assessed the effect of vaccine immunization before the first birthday on eczema severity and allergic sensitization in the second year of life.
METHODS:
A total of 2184 infants, aged 1-2 years, with established atopic dermatitis and a family history of allergy, from 97 study centres in 10 European countries, South Africa and Australia were included. Exposure to vaccines (diphtheria, tetanus, pertussis, polio, Haemophilus influenzae Type B, hepatitis B, mumps, measles, rubella, varicella, BCG, meningococci and pneumococci) and immunization dates were recorded from immunization cards. Immunoglobulin E (IgE) was determined by RAST and eczema severity was assessed by scoring atopic dermatitis (SCORAD).
RESULTS:
Immunization against any target was not associated with an increased risk of allergic sensitization to food or inhalant allergens. Varicella immunization (only 0.7% immunized) was inversely associated with total IgE > 30 kU/l (OR 0.27; 95% CI 0.08-0.87) and eczema severity (OR 0.34; 95% CI 0.12-0.93). Pertussis immunization (only 1.7% nonimmunized) was inversely associated with eczema severity (OR 0.30; 95% CI 0.10-0.89). Cumulative received vaccine doses were inversely associated with eczema severity (P = 0.0107). The immunization coverage of infants before and after the onset of atopic dermatitis was similar.
CONCLUSION:
In children at heightened risk for atopy, common childhood immunization in the first year is not associated with an increased risk of more severe eczema or allergic sensitization. Parents of atopic children should be encouraged to fully immunize their children
Dual identities: the in-service teacher trainee experience in the English further education sector
Get PDFSince 2001 there has been a statutory requirement for teachers in English further education (FE) colleges to gain teaching qualifications. However, in marked distinction from other sectors of education, around 90% of FE teachers are employed untrained, and complete their initial teacher training on a part-time in-service basis. Traditionally, this route has been necessary to attract established vocational practitioners into FE and to enable them to continue earning whilst undertaking their teacher-training. Consequently, staff sustain the dual role of teacher and trainee teacher. This paper explores the dual identities of trainees on in-service FE teacher training courses. It argues that how their two roles interact may cause tensions in their development, shaping and reinforcing a conservative understanding of further education and the role of the FE teacher
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