12 research outputs found
How Might Canadian Women Talk About Peri-Coital Contraception?
No full textThe peri-coital contraceptive pill is a potential method for pregnancy prevention that could be taken in a period before or after unprotected sexual intercourse. However, uptake of a new contraceptive method relies on accessible terminology and frameworks with which to discuss it. I conducted seven focus group discussions across Canada to understand how women talk about different reproductive health technologies, explore the ways these discourses influence language and frameworks women use to talk about peri-coital contraceptives, and identify perceptions of and concerns about this potential method. Women thought the peri-coital contraceptive pill would be a valuable addition to current contraception. They disliked the name ”peri-coital”; although some participants created more resonant names related to unique aspects of this method, many found it challenging to clearly discuss the method with existing language for contraception. Concerted effort to develop terminology that is clearer may help facilitate the eventual introduction of this new contraceptive method in Canada and beyond
How Might Canadian Women Talk About Peri-Coital Contraception?
No full textThe peri-coital contraceptive pill is a potential method for pregnancy prevention that could be taken in a period before or after unprotected sexual intercourse. However, uptake of a new contraceptive method relies on accessible terminology and frameworks with which to discuss it. I conducted seven focus group discussions across Canada to understand how women talk about different reproductive health technologies, explore the ways these discourses influence language and frameworks women use to talk about peri-coital contraceptives, and identify perceptions of and concerns about this potential method. Women thought the peri-coital contraceptive pill would be a valuable addition to current contraception. They disliked the name ”peri-coital”; although some participants created more resonant names related to unique aspects of this method, many found it challenging to clearly discuss the method with existing language for contraception. Concerted effort to develop terminology that is clearer may help facilitate the eventual introduction of this new contraceptive method in Canada and beyond
Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Temporal imaging for atomic single -photon systems
No full textWe demonstrate temporal far -field imaging based on ac -Stark spatial spin-wave phase modulation in a gradient echo memory. We achieve resolution of 20 kHz with MHz level bandwidth and ultra -low noise enabling operation in the single -quantum regime. 2020 The Author(s)</p
Analysis of Primary Health Care Teams and Integration Policy in Ontario
No full textImproving the integration of health services for patients with complex needs is a priority across Canada. To improve patient experience and reduce costs, provinces and territories have implemented diverse team-based primary health care (PHC) models. In Ontario, a boom in both organizational and funding reforms in the early 2000s resulted in the addition of diverse primary care models. The goals of these reforms were to improve the quality of care, care coordination and the comprehensiveness of services. The reforms were reflected at both the provincial and regional (Local Health Integration Networks) levels through strategic guidance documents and through the establishment of primary care evaluation frameworks by key provincial leaders. This study seeks to examine policies and structures that facilitated the development, implementation, and sustainability of team-based PHC models. Analysis of Ontario provincial and regional-level policies released between 2009-2019 reveals that in the last decade, focus has shifted away from highlighting PHC teams as a strategy for integration, instead focusing on broader systems-level integration. Further, primary care evaluation frameworks were not implemented at the local level. More recently, Ontario Health Teams show great promise to reduce silos and improve integration, but the role of primary care and PHC teams in this reform remains unclear.
Partout au Canada, l'amélioration de l'intégration des services de santé pour les patients ayant des besoins complexes est une priorité. Pour améliorer l'expérience des patients et réduire les coûts, les provinces et les territoires ont mis en place divers modèles de soins de santé primaires (SSP) basés sur le travail d’équipe. En Ontario, au début des années 2000, un florilège de réformes organisationnelles et financières ont fait éclore divers modèles de soins de première ligne. Les objectifs de ces réformes étaient d'améliorer la qualité et la coordination des soins, ainsi que d’offrir une gamme complète de services. Ces réformes ont été traduites aux niveaux provinciaux et régionaux (Réseaux Locaux d’Intégration des Services de Santé) dans des documents d’orientation stratégique et des cadres d’évaluation des services de première ligne. Cette étude vise à examiner les politiques et les structures qui ont facilité le développement, la mise en œuvre, et la durabilité des modèles de SSP en équipe. Toutefois, l'analyse des politiques provinciales et régionales de l'Ontario publiées entre 2009 et 2019 révèle qu'au cours de la dernière décennie, l'accent n'a plus été mis sur les équipes de SSP en tant que stratégie d'intégration, mais plutôt sur une intégration plus large au niveau du système de santé. En outre, les cadres d'évaluation des SSP n'ont pas été mis en œuvre au niveau local. Les équipes interdisciplinaires de première ligne de l'Ontario créées plus récemment sont très prometteuses pour réduire les cloisonnements et améliorer l'intégration, mais le rôle des soins primaires et des équipes de SSP dans cette réforme n’a pas été clarifié
Analysis of Primary Health Care Teams and Integration Policy in Ontario
No full textImproving the integration of health services for patients with complex needs is a priority across Canada. To improve patient experience and reduce costs, provinces and territories have implemented diverse team-based primary health care (PHC) models. In Ontario, a boom in both organizational and funding reforms in the early 2000s resulted in the addition of diverse primary care models. The goals of these reforms were to improve the quality of care, care coordination and the comprehensiveness of services. The reforms were reflected at both the provincial and regional (Local Health Integration Networks) levels through strategic guidance documents and through the establishment of primary care evaluation frameworks by key provincial leaders. This study seeks to examine policies and structures that facilitated the development, implementation, and sustainability of team-based PHC models. Analysis of Ontario provincial and regional-level policies released between 2009-2019 reveals that in the last decade, focus has shifted away from highlighting PHC teams as a strategy for integration, instead focusing on broader systems-level integration. Further, primary care evaluation frameworks were not implemented at the local level. More recently, Ontario Health Teams show great promise to reduce silos and improve integration, but the role of primary care and PHC teams in this reform remains unclear.
Partout au Canada, l'amélioration de l'intégration des services de santé pour les patients ayant des besoins complexes est une priorité. Pour améliorer l'expérience des patients et réduire les coûts, les provinces et les territoires ont mis en place divers modèles de soins de santé primaires (SSP) basés sur le travail d’équipe. En Ontario, au début des années 2000, un florilège de réformes organisationnelles et financières ont fait éclore divers modèles de soins de première ligne. Les objectifs de ces réformes étaient d'améliorer la qualité et la coordination des soins, ainsi que d’offrir une gamme complète de services. Ces réformes ont été traduites aux niveaux provinciaux et régionaux (Réseaux Locaux d’Intégration des Services de Santé) dans des documents d’orientation stratégique et des cadres d’évaluation des services de première ligne. Cette étude vise à examiner les politiques et les structures qui ont facilité le développement, la mise en œuvre, et la durabilité des modèles de SSP en équipe. Toutefois, l'analyse des politiques provinciales et régionales de l'Ontario publiées entre 2009 et 2019 révèle qu'au cours de la dernière décennie, l'accent n'a plus été mis sur les équipes de SSP en tant que stratégie d'intégration, mais plutôt sur une intégration plus large au niveau du système de santé. En outre, les cadres d'évaluation des SSP n'ont pas été mis en œuvre au niveau local. Les équipes interdisciplinaires de première ligne de l'Ontario créées plus récemment sont très prometteuses pour réduire les cloisonnements et améliorer l'intégration, mais le rôle des soins primaires et des équipes de SSP dans cette réforme n’a pas été clarifié
Naturally Occurring Retirement Communities: Scoping Review
No full textBACKGROUND: As Canada’s population ages, there is a need to explore community-based solutions to support older adults. Naturally occurring retirement communities (NORCs), defined in 1986 as buildings or areas not specifically designed for, but which attract, older adults and associated NORC supportive service programs (NORC-SSPs) have been described as potential resources to support aging in place. Though the body of literature on NORCs has been growing since the 1980s, no synthesis of this work has been conducted to date. OBJECTIVE: The goal of this scoping review is to highlight the current state of NORC literature to inform future research and offer a summarized description of NORCs and how they have supported, and can support, older adults to age in place. METHODS: Using a published framework, a scoping review was conducted by searching 13 databases from earliest date of coverage to January 2022. We included English peer- and non–peer-reviewed scholarly journal publications that described, critiqued, reflected on, or researched NORCs. Aging-in-place literature with little to no mention of NORCs was excluded, as were studies that recruited participants from NORCs but did not connect findings to the setting. A qualitative content analysis of the literature was conducted, guided by a conceptual framework, to examine the promise of NORC programs to promote aging in place. RESULTS: From 787 publications, we included 64 (8.1%) articles. All publications were North American, and nearly half used a descriptive research approach (31/64, 48%). A little more than half provided a specific definition of a NORC (33/64, 52%); of these, 13 (39%) used the 1986 definition; yet, there were discrepancies in the defined proportions of older adults that constitute a NORC (eg, 40% or 50%). Of the 64 articles, 6 (9%) described processes for identifying NORCs and 39 (61%) specifically described NORC-SSPs and included both external partnerships with organizations for service delivery (33/39, 85%) and internal resources such as staff, volunteers, or neighbors. Identified key components of a NORC-SSP included activities fostering social relationships (25/64, 39%) and access to resources and services (26/64, 41%). Sustainability and funding of NORC-SSPs were described (27/64, 42%), particularly as challenges to success. Initial outcomes, including self-efficacy (6/64, 9%) and increased access to social and health supports (14/64, 22%) were cited; however, long-term outcomes were lacking. CONCLUSIONS: This review synthesizes the NORC literature to date and demonstrates that NORC-SSPs have potential as an alternative model of supporting aging in place. Longitudinal research exploring the impacts of both NORCs and NORC-SSPs on older adult health and well-being is recommended. Future research should also explore ways to improve the sustainability of NORC-SSPs
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
Patient, family member and caregiver engagement in shaping policy for primary health care teams in three Canadian Provinces
No full textAbstract Introduction Improving health services integration through primary health care (PHC) teams for patients with chronic conditions is essential to address their complex health needs and facilitate better health outcomes. The objective of this study was to explore if and how patients, family members, and caregivers were engaged or wanted to be engaged in developing, implementing and evaluating health policies related to PHC teams. This patient‐oriented research was carried out in three provinces across Canada: British Columbia, Alberta and Ontario. Methods A total of 29 semi‐structured interviews with patients were conducted across the three provinces and data were analysed using thematic analysis. Results Three key themes were identified: motivation for policy engagement, experiences with policy engagement and barriers to engagement in policy. The majority of participants in the study wanted to be engaged in policy processes and advocate for integrated care through PHC teams. Barriers to patient engagement in policy, such as lack of opportunities for engagement, power imbalances, tokenism, lack of accessibility of engagement opportunities and experiences of racism and discrimination were also identified. Conclusion This study increases the understanding of patient, family member, and caregiver engagement in policy related to PHC team integration and the barriers that currently exist in this engagement process. This information can be used to guide decision‐makers on how to improve the delivery of integrated health services through PHC teams and enhance patient, family member, and caregiver engagement in PHC policy. Patient or Public Contribution We would like to acknowledge the contributions of our patient partners, Brenda Jagroop and Judy Birdsell, who assisted with developing and pilot testing the interview guide. Judy Birdsell also assisted with the preparation of this manuscript. This study also engaged patients, family members, and caregivers to share their experiences with engagement in PHC policy
Yonetani–Theorell plot for the inhibition of HIV-1 RT in the presence of the NNRTI calanolide A and β-thujaplicinol
No full text<p><b>Copyright information:</b></p><p>Taken from "Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones"</p><p>Nucleic Acids Research 2005;33(4):1249-1256.</p><p>Published online 1 Mar 2005</p><p>PMCID:PMC552956.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> The inverse of the rate of RNase H cleavage was plotted as a function of β-thujaplicinol concentration at calanolide A concentrations of 12.5 μM (open square), 0.78 μM (filled square), 0.39 μM (open circle) and DMSO (filled circle). The convergent best-fit lines indicate mutually exclusive binding sites for calanolide A and β-thujaplicinol
