54 research outputs found
Results of two different conditioning regimens followed by ABMT in refractory acute lymphoblastic leukemia
No full text[No abstract available
Exact moment analysis of transient/asymptotic dispersion properties in periodic media with adsorbing/desorbing walls
No full textThe paper develops a robust and computationally efficient homogenization approach, grounded on exact local and integral moments, to investigate the temporal evolution of effective dispersion properties of solute particles in periodic media possessing absorbing/desorbing walls. Adsorption onto and desorption from active walls allow linear and reversible mass transfer between the solid surface and the fluid phase. The transient analysis reveals some important features of the dispersion process that cannot be captured by asymptotic approaches aimed at determining exclusively the long-range/large-distance dispersion properties. Two case studies are considered: the dispersion of an analyte in a sinusoidal channel with adsorbing/desorbing walls and the retentive pillar array column for liquid chromatography. For both systems, the transient analysis shows how the tortuous fluid motion induced by the sinusoidal walls or by the presence of pillars induces wide and persistent temporal oscillations of the effective velocity and dispersion coefficient even for a steady (non-pulsating) Stokes flow. The adsorption/desorption process strongly amplifies the phenomenon of the overshoot for the effective dispersion coefficient that, on short/intermediate time scales, reaches values significantly larger than the asymptotic one. Moreover, the method proposed allows a detailed analysis of the temporal evolution of the skewness of the marginal distribution of the analyte along the main stream direction. It clearly shows that the time scale for achieving the macro-transport regime, which implies a Gaussian (symmetric) marginal pdf, is largely underestimated if one bases the analysis on the attainment of constant asymptotic values for the effective velocity and for the dispersion coefficient. © 2022 Author(s)
Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over
No full textBladder cancer is the most common tumor of the urinary tract, with a worldwide incidence of 8.6 x 100000 in men and 2.6 x 100000 in women (1). The majority of patients (75-85%) present as non-muscle invasive bladder cancer (NMIBC); within this category the most represented stage is Ta (70%), followed by T1 (20%) and, less frequently, carcinoma in situ (CIS) (10%) (2). The diagnosis of NMIBC and, more generally, of bladder cancer, depends on urine cytology and endoscopic examination with histological evaluation of the resected tissue. Clearly, an optimal cystoscopy with accurate transurethral resection (TUR) is of great importance in order to improve the detection rate and to reduce the probability of recurrence and progression. Today the cystoscopy is routinely performed with the white light technique (WLC), the same of about 80 years ago (3). Several studies have demonstrated that an initial TUR with WLC can miss small papillary lesions and, particularly, flat lesions such as CIS. Moreover, recurrence rates of non-muscle invasive bladder cancer (NMIBC) are directly related to the possibility of achieving a complete resection: residual cancer is present in a large percentage of re-TUR, showing a not so good performance of resection with this method. For these reasons new methodologies have been investigated in order to improve the sensitivity and specificity of WLC, such as photodynamic diagnosis (PDD), narrow band imaging (NBI), optical coherence tomography (OCT) and CT virtual cystoscopy. Some of them have been well established and supported by consistent literature while others are still to be viewed as experimental. The purpose of this review is to investigate the state of the art of these new technique
Prevedeni (mikro)svetovi: Roman Vojak s cvetlico Nándorja Giona v slovenskem, nemškem in srbskem prevodu
No full textTRANSLATED (MICRO) WORLDS: THE NOVEL SOLDIER-WITH-FLOWER BY NÁNDOR GION IN SLOVENE, GERMAN AND SERBIAN TRANSLATIONS
The lexicon of the novel Soldier-With-Flower by the Hungarian author Nándor Gion presents rich historical, cultural-historical, ethnological and anthropological material. The current research focuses above all on the aspects of translations into Serbian, German, and Slovene. The analysis focuses on the translation of culturally specific details with attention to the notion that a translation is not merely a function of grammar and vocabulary of both languages, but an intercultural communication, i.e., a cultural exchange. In the intercultural translation any aspect of reality can be “translated” by implying various translation strategies. A translation is a carrier of the source culture and as such should be considered a significant element of intercultural communication. As the culture is an organized system of symbols, the carriers of meanings, it is on the one hand a "model of reality" and on the other a "model of truth" (Iser).Besedilni svet romana Vojak s cvetlico madžarskega pisatelja Nándorja Giona kopiči bogato krajevnozgodovinsko, kulturnozgodovinsko, narodopisno in antropološko gradivo. Razprava se v prvi vrsti loteva razkrivanja vidikov, ki se uveljavljajo pri prevajanju romana v srbski, nemški in slovenski jezik. Osredotoča se na prevajanje kulturnih posebnosti in pri tem izhaja iz dejstva, da prevod ni samo akt gramatike in besednega zaklada dveh jezikov, temveč medkulturna komunikacija oziroma kulturna menjava, pri kateri je z različnimi prevajalskimi postopki in metodami »prevedljiv« vsak del resničnosti. Prevedeno delo namreč v veliki meri prenaša tudi kulturo, iz katere izhaja, tako da je bistveni element medkulturnega stika. Kultura je navsezadnje organiziran sistem simbolov, nosilcev pomena, ki je po Iserju »po eni strani model o resničnosti, po drugi strani pa model resnice.
Corrigendum: The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry (Future Oncology (2018) 14:26 (2713-2723) DOI: 10.2217/fon-2018-0291)
No full textFollowing publication of the Research Article by SerenaMerante, Virginia V Ferretti, Chiara Elena, Valeria Brazzelli, Roberta Zanotti, Iria Neri, DiomiraMaglicane, Anna Belloni Fortina, Forer Ingeborg, Elide A Pastorello, Lisa Pieri, Cristina Papayannidis, Marina Mauro, Federica Grifoni, Roberto Minelli, Elena Guggiari, Elisa Difonzo, Monica Bocchia, Francesca Caroppo, Sergio DiNuzzo, ElenaMaria Elli,Michaela Rondoni, Rachele Ciccocioppo,Michele Di Stefano, Grazia Bossi, Emanuela Boveri, Patrizia Bonadonna, Fiorina Giona, Peter Valent &Massimo Triggiani, titled 'The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry', which appeared in the November 2018 issue of Future Oncology (Future Oncology [Lond.] 14[26], 2713-2723 [2018]; DOI: 10.2217/fon-2018-0291), it has been brought to our attention that the name of Iria Neri has been corrected as follows: The author name was originally published as Iria Ner, and has been corrected to Iria Neri. The authors and editors of Future Oncology would like to sincerely apologise for any confusion or inconvenience this may have caused our readers
Penile length is preserved after implant surgery
No full textObjective: To investigate if there is a correlation between penile size measured preoperatively and erect penis after penile implant surgery (PI). A common cause of patient dissatisfaction after PI is caused by patients complaining that surgery has shortened the penis. It has been suggested that stretched penile length preoperatively is almost the same after surgery when the prosthesis is in erect status. However, no comprehensive data supports this theory. This prospective study was done to investigate this theory. Patients and Methods: Standardised measurements of stretched penile length and girth were performed in theatre before PI implantation then re-measured at the end of the procedure with the penis in the erect position. We recorded type of PI, cylinder lengths and malleable rod diameters. All patients had data recorded on body mass index (BMI), hypertension (HTN), glycated haemoglobin (HbA1c), and Peyronie's disease (PD). Results: In all, 133 patients were assessed; 88 (66.2%) had a malleable penile prosthesis (MPP) and 45 (33.8%) an inflatable penile prosthesis (IPP). The median age and BMI were 56 years and 30 kg/m2, respectively. In all, 40 (30.1%) patients had HTN, 37 (27.8%) had PD, and 89 (66.9%) were diabetic. The mean (SD) pre-implant stretched length was 12.8 (1.8) cm. The mean (SD) flaccid girth was 10.3 (1.2) cm. Postoperatively, the mean (SD) erect length and girth were 13.1 (1.7) cm and 11.3 (1.3) cm, respectively. Overall, there was a significant (P < 0.05) increase in both the mean (SD) length at +0.36 (0.63) cm, and girth at +1.04 (1.02) cm. Patients who had an IPP, had a greater increase in both length (mean [SD] 0.62 [0.72] cm) and girth (mean [SD] 1.7 [1.0] cm) compared to those who had a MPP (mean [SD] 0.22 [0.53] cm and 0.7 [0.87] cm, respectively) (P < 0.05). We investigated correlations between pre- and postoperative outcomes related to BMI, HTN, diabetes, and PD. None of these variables affected outcome. Conclusions: PI surgery does not significantly decrease penile size compared to the preoperative assessment. The outcome was not affected by co-morbidities. The preoperative length and girth correlated well with the immediate postoperative erect penis, although girth was not necessarily comparable in this series of patients measured under anaesthesia. Recording penile dimensions in the clinic and agreeing these with patients’ preoperatively may be a way of improving satisfaction levels with this surgery
Twenty years of the Italian Fanconi Anemia Registry: Where we stand and what remains to be learned
No full textThe natural history of Fanconi anemia remains hard to establish because of its rarity and its heterogeneous clinical presentation; since 1994, the Italian Fanconi Anemia Registry has collected clinical, epidemiological and genetic data of Italian Fanconi Anemia patients. This registry includes 180 patients with a confirmed diagnosis of Fanconi anemia who have either been enrolled prospectively, at diagnosis, or later on. After enrollment, follow-up data were periodically collected to assess the clinical course, possible complications and long-term survival; the median follow up was 15.6 years. The main goal of the study was to describe the natural history of Fanconi anemia, focusing on the following variables: family history, disease presentation, development of hematological manifestations, development of malignancies, occurrence of hematopoietic stem cell transplantation and survival. Typical morphological and/or hematological abnormalities and/or growth retardation were the most common manifestations at diagnosis; the majority of patients (77%) exhibited hematological abnormalities at the initial presentation, and almost all (96%) eventually developed hematological manifestations. More than half of the patients (57%) underwent a bone-marrow transplant. The occurrence of cancer was quite rare at diagnosis, whereas the cumulative incidence of malignancies at 10, 20 and 30 years was 5%, 8% and 22%, respectively, for hematological cancers and 1%, 15% and 32%, respectively, for solid tumors. Overall survival at 10, 20 and 30 years were 88%, 56% and 37%, respectively; the main causes of death were cancer, complications of the hematological presentation and complications of transplantation. These data clearly confirm the detrimental outcome of Fanconi anemia, with no major improvement in the past decades
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