108 research outputs found
Le complexe de la complexité : déplacement multidimensionnel dans l’œuvre de Dai Sijie
No full textIl n’est plus possible de tracer les contours de la littérature chinoise en tant qu’entité « située » dans un espace bien défini. La littérature elle-même est désormais déterritorialisée. Une manifestation évidente de ce déplacement au sens large est la littérature de la diaspora, en particulier dans le cas où elle est rédigée dans une langue étrangère. Dans le contexte francophone, Dai Sijie est l’un des auteurs les plus connus parmi les écrivains assimilables à la diaspora chinoise et, parmi d’autres, son roman Le Complexe de Di (2003) constitue un excellent exemple de la manière dont la question du déplacement de l’individu peut être abordée depuis plusieurs perspectives. Cet article vise à montrer les différents niveaux auxquels l’auteur exprime sa transidentité et son hybridation linguistique et culturelle. Il explore trois interprétations d’un mouvement qui est à la fois linguistique, culturel et spatial, pour montrer le lien entre la représentation de l’espace et la complexité identitaire dérivant d’une « sinité » mondialisée.It is no longer possible to trace the contours of Chinese literature conceived as an entity “located” in a well-defined space. Literature itself is now deterritorialized. A clear manifestation of this displacement in the broad sense is the literature of the diaspora, in particular when it is written in a foreign language. In the French context, Dai Sijie is one of the best-known authors ascribable to the Chinese diaspora and, among the others, his novel Le Complexe de Di (2003) constitutes an excellent example of how the issue of the individual’s displacement can be represented from several perspectives. This article aims to show the different filters through which the author expresses his transidentity as well as by his linguistic and cultural hybridization. It explores three interpretations of a movement that is simultaneously linguistic, cultural and spatial, to investigate the link between the representation of space and the identity complexity deriving from a globalized “Chineseness.
Il consumatore insoddisfatto
No full textNell'ambito del consumo si producono inevitabilmente delle forti disparità sociali e quindi dei fattori in grado di generare insoddisfazione negli individui. Il saggio si occupa del problema dell’insoddisfazione del consumatore, soprattutto a partire dalle riflessioni sviluppate negli ultimi anni su tale problema da Zygmunt Bauman e Gilles Lipovetsky
Smog and the Psyche: Chen Qiufan’s Reading of the Urban Anthropocene
No full textThe growing concern for environmental issues has fuelled the rise of climate fiction [cli-fi], a subgenre of science fiction dealing with climate change that has become increasingly popular in the last few decades. In China, significant examples can be found, among others, in Chen Qiufan’s works, which address these problems from different points of view. In his short story “Mai” 霾 [The Smog Society], the author explores the relationship between human beings and nature from an unconventional perspective, overturning the traditional conception of the relationship between the environment and the human mind. This article aims to analyse Chen Qiufan’s short story as an attempt to subvert the causal relationship between pollution and happiness, outlining his interpretation of the urban Anthropocene. The analysis will set out from what Glenn Albrecht has defined as “psychoterratic emotional concepts”, namely earth-related mental health conditions, to explore the author’s view of man-made climate change. In particular, it will explore the depiction of the climatic emergency in the Chinese urban context and its consequences on the protagonist’s psychology and emotions, as well as on urban social life
Data and results from Spage2vec: Unsupervised detection of spatial gene expression constellations
No full textThis repository contains spatial gene expression data from three in situ transcriptomic assayes together with analysis results from spage2vec manuscript.
Acknowledgement:
We thank Xiaoyan Qian, Simone Codeluppi and Jeffrey Moffitt for generating and sharing in situ sequencing [1], osmFISH [2] and MERFISH [3] datasets, respectively. And Jeongbin Park, Wonyl Choi for uploading osmFISH and MERFISH data to public repository.
[1] Qian, Xiaoyan, et al. "Probabilistic cell typing enables fine mapping of closely related cell types in situ." Nature methods 17.1 (2020): 101-106.
[2] Codeluppi, Simone, et al. "Spatial organization of the somatosensory cortex revealed by osmFISH." Nature methods 15.11 (2018): 932-935.
[3] Moffitt, Jeffrey R., et al. "Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region." Science 362.6416 (2018): eaau5324
Mobility in Unsupervised Word Embeddings for Knowledge Extraction—The Scholars’ Trajectories across Research Topics
No full textIn the knowledge discovery field of the Big Data domain the analysis of geographic positioning and mobility information plays a key role. At the same time, in the Natural Language Processing (NLP) domain pre-trained models such as BERT and word embedding algorithms such as Word2Vec enabled a rich encoding of words that allows mapping textual data into points of an arbitrary multi-dimensional space, in which the notion of proximity reflects an association among terms or topics. The main contribution of this paper is to show how analytical tools, traditionally adopted to deal with geographic data to measure the mobility of an agent in a time interval, can also be effectively applied to extract knowledge in a semantic realm, such as a semantic space of words and topics, looking for latent trajectories that can benefit the properties of neural network latent representations. As a case study, the Scopus database was queried about works of highly cited researchers in recent years. On this basis, we performed a dynamic analysis, for measuring the Radius of Gyration as an index of the mobility of researchers across scientific topics. The semantic space is built from the automatic analysis of the paper abstracts of each author. In particular, we evaluated two different methodologies to build the semantic space and we found that Word2Vec embeddings perform better than the BERT ones for this task. Finally, The scholars’ trajectories show some latent properties of this model, which also represent new scientific contributions of this work. These properties include (i) the correlation between the scientific mobility and the achievement of scientific results, measured through the H-index; (ii) differences in the behavior of researchers working in different countries and subjects; and (iii) some interesting similarities between mobility patterns in this semantic realm and those typically observed in the case of human mobility
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Activation of the mTOR pathway in astrocytes after spinal cord ischemia
No full textSpinal cord injury is characterized by cell death, macrophage infiltration, and formation of a glial scar. Functional recovery from this severe damage is dependent on the regeneration and growth of the axons of the surviving neurons beyond the lesion site and on the formation of the proper synaptic connections between the axons and their targets. However, the regeneration process is affected by inhibitory molecules expressed by the astrocytes of the glial scar and derived from the rupture of the myelin sheats. A better environment for spinal cord regeneration can be created by regulating glial scar formation and by blocking the effects of the myelin derived inhibitors. In the adult central nervous system, epidermal growth factor (EGF) regulates astrocyte activation and scar formation. Inhibition of EGF receptor signaling showed beneficial effects and promoted functional recovery and locomotion in an animal model of contusion-induced spinal cord injury. We showed that EGF receptor activates the mammalian target of rapamycin (mTOR) pathway in primary cultures of adult spinal cord astrocytes. EGF receptor activation causes Akt mediated phosphorylation and downregulation of the mTOR pathway inhibitor Tuberin. Since Tuberin is a GTPase-activating protein that regulates the activity of the small GTPase Rheb, EGF treatment increases Rheb and mTOR activity. Furthermore, in primary cultures of spinal cord astrocytes, mTOR regulates proliferation and EGF-induced migration. We also detected increased activation of the EGF receptor and the mTOR pathway in hypertrophic astrocytes in the spinal cord after ischemia-induced injury. These in vitro and in vivo findings suggest that EGF-induced astrocyte hypertrophy is regulated by the mTOR pathway. Inhibition of mTOR activity with rapamycin may reduce astrocyte hypertrophy as well as scar formation and prove beneficial for axonal regeneration and functional recovery after spinal cord injur
Accurate length determination of DNA molecules visualized by atomic force microscopy: evidence for a partial B- to A-form transition on mica
No full textIL-6 secretion by astrocytes
No full text<p>SFN2013 nanosymposium presentation on IL-6 secretion by astrocytes</p
Le scuole sociologiche e la relazione tra natura e cultura
No full textÈ la società a determinare le peculiarità di una cultura specifica o sono le caratteristiche culturali a specificare i rapporti di un sistema sociale? La cultura si riduce a una sovrastruttura dipendente da una struttura economica e materiale profonda che ne guida l’orientamento ideologico, simbolico e produttivo come ritiene la teoria marxista ; oppure dobbiamo partire da indipendenza e autonomia delle variabili culturali rispetto agli altri aspetti che determinano il sociale ? Sulla scorta delle precedenti considerazioni qual è il rapporto tra natura e cultura? Se per Natura intendiamo ciò che non viene insegnato, perché contenuto nel corredo genetico innato degli esseri umani, in che modo essa influenza e viene influenzata dalla cultura? Se la Cultura è costruzione dell’uomo, il quale associandosi in gruppi produce idee, simboli e artefatti, è possibile che tale produzione modifichi e sofistichi la natura umana? Esiste una innata inclinazione naturale dell’uomo alla costruzione dell’artificio culturale? Se esistono leggi solo naturali, in che modo si distinguono dalle norme culturali?
Nei secoli gli scienziati sociali hanno stabilito nessi causali forti, deboli, circolari o relazionali, univoci o reciproci tra natura e cultura. Le precedenti domande costituiscono il fondamento di differenti paradigmi che li hanno posti
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