63 research outputs found
Mayor Woody Dumas Receiving Christmas Plants Grown by BRACA
No full textMayor Woody Dumas receiving Christmas plants grown by BRACA employees to raise funds. Author Jackson, BRACA Director, making the presentation. Date: ca. 1970'
Ship detection using GNSS-reflectometry in backscattering configuration
No full textThe chance of exploiting the Global Navigation Satellite Systems-Reflectometry (GNSS-R) remote sensing technology in the field of maritime surveillance and ship traffic monitoring has been explored in the very recent past. The conventional bistatic GNSS-R is based on the acquisition of GNSS navigation messages in a forward-scattering geometry, where the investigated region surrounds the specular reflection point. The peculiarities of the ship detection problem, where man-made dihedral structures come into play, make the conventional configuration unsuitable for such an application, especially from spaceborne platforms. Very recently, the backscattering configuration has been demonstrated to greatly enhance the presence of targets within GNSS-R delay-Doppler maps (DDM). In this paper, a thorough comparison of the forward-and back-scattering configurations for ship detection application from spaceborne GNSS-R instruments is presented in order to quantitatively evaluate the benefits of the backscattering configuration with respect to the conventional one. The analysis is performed by computing the signal-to-noise-plus-clutter ratio in both configurations as a function of the sea state, ship orientation and radar look angle
Ship detection using GNSS-Reflectometry in backscattering configuration
No full textThe chance of exploiting the Global Navigation Satellite Systems-Reflectometry (GNSS-R) remote sensing technology in the field of maritime surveillance and ship traffic monitoring has been explored in the very recent past. The conventional bistatic GNSS-R is based on the acquisition of GNSS navigation messages in a forward-scattering geometry, where the investigated region surrounds the specular reflection point. The peculiarities of the ship detection problem, where man-made dihedral structures come into play, make the conventional configuration unsuitable for such an application, especially from spaceborne platforms. Very recently, the backscattering configuration has been demonstrated to greatly enhance the presence of targets within GNSS-R delay-Doppler maps (DDM). In this paper, a thorough comparison of the forward- and back-scattering configurations for ship detection application from spaceborne GNSS-R instruments is presented in order to quantitatively evaluate the benefits of the backscattering configuration with respect to the conventional one. The analysis is performed by computing the signal-to-noise-plus-clutter ratio in both configurations as a function of the sea state, ship orientation and radar look angle
Anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of vestibular migraine: A prospective observational cohort study
No full textBackground: Vestibular migraine is considered the most common cause of recurrent vertigo for which specific treatments are missing. Monoclonal antibodies against calcitonin gene-related peptide,, are effective in preventing migraine. Since CGRP is also detected in human cochlear and vestibular organs it may also play a role in vestibular physiology. Methods: This is a prospective observational cohort study, aiming at evaluating the efficacy of erenumab, fremanezumab or galcanezumab for the treatment of fifty vestibular migraine patients. We assessed mean monthly days with headache and dizziness/vestibular symptoms, pain intensity and migraine-related clinical burden occurring for 18 months. Results: Response to treatment was excellent as 45 (90%) patients had at least a 50% reduction in vertigo frequency, 43 (86%) had at least a 50% reduction in headache frequency, and 40 (80%) a MIDAS reduction of at least 50%. Overall, 39 (78%) patients had a concomitant reduction of all three parameters. Mean monthly days with dizziness/vestibular symptoms showed an overall significant decrease from a mean of 10.3 ± 1.9 at baseline to 0.8 ± 0.3 days, difference 9.5 (CI 95% 3.6, 15.4; p < 0.001) after twelve months. Conclusion: We show that anti-CGRP mAbs may be effective in the treatment of Vestibular Migraine. Their use should be encouraged early in the disease course to allow for a better symptom control and quality of life improvement
Are anti-calcitonin gene-related peptide monoclonal antibodies effective in treating migraine aura? A pilot prospective observational cohort study
No full textBackground: About 15% to one third of migraineurs experience aura symptoms. Aura is a reversible focal neurological phenomenon involving visual, sensory, speech, and motor symptoms that usually precede migraine pain. Monoclonal antibodies against calcitonin-related peptide (anti- CGRP mAbs) are effective in preventing chronic and episodic migraine, but little is known about their effectiveness on specifically preventing migraine with aura. Methods: This is a pilot prospective observational cohort study, aiming at evaluating the effectiveness and safety of Erenumab, Fremanezumab or Galcanezumab for the treatment of migraine aura. We enrolled 14 patients at the Headache Centre of University Federico II of Naples. Duration of follow-up was 12 months. We assessed mean monthly days with aura symptoms, with or without subsequent headache, as well as mean monthly days with headache and mean monthly MIDAS score, by reviewing standardized paper patient headache diaries every three months. Results: A significant decrease in mean monthly aura days was observed throughout the observation period (median baseline: 13, interquartile range: 4-16; after 12 months: 1, interquartile range: 0-3, p < 0.001). We observed a statistically significant decrease in mean monthly headache days as well (median baseline 21, interquartile range: 16-30; after 12 months: 5, interquartile range: 4-7, p < 0.001). During the 12-month treatment period, none of the 14 patients reported mild or serious adverse events. Conclusion: Our findings suggest that anti-CGRP mAbs are highly effective in migraine with aura, both in reducing mean monthly aura days and mean monthly days with headache
The putative role of trigemino-vascular system in brain perfusion homeostasis and the significance of the migraine attack
No full textBesides representing the place where a migraine attack generates, what is the physiological role of peptidergic control of arteriolar caliber within the trigemino-vascular system? Considering that the shared goal of most human CGRP-based neurosensory systems is the protection from an acute threat, especially if hypoxic, what is the end meaning of a migraine attack? In this paper, we have reviewed available evidence on the possible role of the trigemino-vascular system in maintaining cerebral perfusion pressure homeostasis, despite the large physiological fluctuations in intracranial pressure occurring in daily life activities. In this perspective, the migraine attack is presented as the response to a cerebral hypoxic threat consequent to a deranged intracranial pressure control aimed at generating a temporary withdrawal from the environment with limitation of physical activity, a condition required to promote the restoration of cerebral fluids dynamic balance
A head‐to‐head observational cohort study on the efficacy and safety of monoclonal antibodies against calcitonin gene–related peptide for chronic and episodic migraine
No full textObjective: To compare the effectiveness and safety of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine, through real-world data. Background: Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have been tested extensively in several clinical trials for both episodic and chronic migraine, showing high effectiveness, safety, and tolerability; however, there are no prospective real-world studies intending to compare their efficacy and safety. Methods: This is a prospective observational cohort study comparing the effectiveness and safety profiles of galcanezumab, fremanezumab, and erenumab for the treatment of chronic and episodic migraine. We enrolled 140 patients at the Headache Centre of University Federico II of Naples, with a history of multiple failed treatments with validated migraine preventatives. Framenezumab, erenumab, or galcanezumab were administered for 12 months. The mean monthly days with headache, Migraine Disability Assessment (MIDAS) score, and adverse events were evaluated during the run-in period and every 3 months by reviewing standardized paper patient headache diaries. Results: We found a mean reduction of migraine monthly days from baseline of -12.0 (-9.8, -14.1) in the galcanezumab group, -12.3 (-10.2, -14.3) in the fremanezumab group, and -10.8 (-8.5, -13.1) in the erenumab group (for all, p < 0.001). We found a mean reduction of MIDAS score of -32.6 (-26.6, -38.5) in the galcanezumab group, -33.4 (-28.0, -38.9) in the fremanezumab group, and -29.2 (-23.0, -35.4) in the erenumab group (for all, p < 0.001). We found no significant differences between mAbs in the reduction of mean monthly days with headache and MIDAS score. We found a more rapid effect of galcanezumab and erenumab compared to fremanezumab in medication overuse headache patients after 3 months of treatment (-10.8 and -11.1 vs. -4.0 days; p = 0.029). Conclusion: Our results confirm the therapeutic benefits of anti-CGRP mAbs. There is no evidence that suggests that one antibody may be superior to the others in terms of effectiveness, both in chronic and episodic patients
Joachimite Bibliography 2017
No full textThis annotated bibliography details the publications dedicated to the life and works of Joachim of Fiore, to the development of his hermeneutics and to the influence of his works on other authors. For the latter, the bibliography includes only the studies that show a consistent interest in the figure and the thought of Joachim. Studies concerned with Joachimite authors that show no interest in the analysis of Joachim’s influence on their thinking have not been included. The entries are ordered alphabetically by the surname of the author. Each study is presented with a comment to highlight the content of interest
Joachimite Bibliography 2018
No full textThis annotated bibliography details the publications dedicated to the life and works of Joachim of Fiore, to the development of his hermeneutics and to the influence of his works on other authors. For the latter, the bibliography includes only the studies that show a consistent interest in the figure and the thought of Joachim. Studies concerned with Joachimite authors that show no interest in the analysis of Joachim’s influence on their thinking have not been included. The entries are ordered alphabetically by the surname of the author. Each study is presented with a comment to highlight the content of interest
Joachimite Bibliography 2015
No full textThis annotated bibliography details the publications dedicated to the life and works of Joachim of Fiore, to the development of his hermeneutics and to the influence of his works on other authors. For the latter, the bibliography includes only the studies that show a consistent interest in the figure and the thought of Joachim. Studies concerned with Joachimite authors that show no interest in the analysis of Joachim’s influence on their thinking have not been included. The entries are ordered alphabetically by the surname of the author. Each study is presented with a comment to highlight the content of interest
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