118 research outputs found
The cytotoxic effect of slow Loris (nycticebus) venom, on human cancer cells
No full textWithin the Kingdom Mammalia, venom evolution is rare, occurring in only six orders. Arguably the most cryptic, and academically neglected venom occurs within primates among slow lorises (Nycticebus spp.). Venoms comprise novel biological compounds with a potential plethora of proteins and peptides available for utilisation in bio-medical research. We collected samples of slow loris saliva from eight captive-bred pygmy slow lorises (N. pygmaeus) at Paignton Zoo and Shaldon Wildlife Trust UK, given voluntarily as slow lorises chewed on Salimetrics children’s swabs. From January to March 2017, we employed MTT assays, and microscopy assessments to determine cell survival on human epidermal carcinoma cells (A431 line) after the application of concentrations of slow loris salivary venom. Cell survival from both male and female derived saliva was half that of untreated cells. Cytotoxic action is demonstrated in concentrations as low as 0.01% venom. Results demonstrate a cytotoxic effect with ensuing physiological damage on human cancer cells, demonstrating the cytotoxic action of slow loris saliva only, without the admixture of brachial gland exudate. We show that even captive-bred slow loris saliva harbours potentially dangerous substances, with functional applications towards slow loris husbandry. Knowledge of slow loris salivary venom increases understanding of the novel salivary composition and supports discussions of slow loris conservation by proposing a functional narrative to oppose the illegal pet trade, by contradicting their ‘cute and cuddly’ appeal. Evidence of salivary venom shows that cytotoxic effects can result even in the absence of a bite puncturing the skin, and further demonstrates their inappropriateness as pets
Iscrizione nei libri contabili obbligatori e circolazione dei debiti aziendali (con alcune considerazioni sui criteri di imputazione e di responsabilità tra diritto civile e diritto commerciale)
No full textThe author, inspired by a recent jurisprudential conflict emerged in the judgments passed by the Italian Supreme Court about the legal interpretation of the section 2560, paragraph 2 c.c. (which states the assumption of the company debts), examines the most important and recent Italian theories about the legal framework of the company and shows how the different solutions to the issue are dictated by a different concept of the subjective imputation criteria and the liability for breach of contract
The sticky tasty: the nutritional content of the exudativorous diet of the Javan slow loris in a lowland forest
No full textPlant exudates are an important food source for many primates. The Critically Endangered Javan slow loris (Nycticebus javanicus) was previously found to prefer Acacia decurrens exudate in an anthropogenically disturbed site, while its feeding habits in secondary natural forest remain unknown. Knowledge of the chemical characteristics of the plant exudates that Javan slow lorises consume is limited, especially with respect to those that they feed on in natural forests. As plant exudates may contain plant secondary metabolites (PSM), which are considered unpalatable in high concentrations, differences in PSM composition may drive feeding preferences. This research aims firstly to confirm exudate consumption by the Javan slow loris in a lowland tropical forest in Central Java, and secondly to identify the chemical characteristics of the exudates consumed. We followed wild slow lorises in Kemuning Forest, Central Java and observed their behaviour. We investigated the gum-producing trees that were utilized by the slow lorises by tapping the exudates and examining their nutritional and PSM contents. We found that exudates are the predominant food source for the Javan slow loris in this lowland forest, and that their nutritional contents are similar to those of exudates consumed by lorises in anthropogenically disturbed areas. Significant differences in polysaccharide and flavonoid contents were found between consumed and unconsumed exudates. Knowledge of the diet of the Javan slow loris is crucial to its conservation, and our findings confirm the importance of exudates in its diet. We also highlight the need to preserve natural slow loris habitat, and to manage the diets of these species in captivity. The results of this study indicate that plant exudates should constitute a significant portion of the diet of captive slow lorises, and that the presence of exudate-producing trees is vital in areas into which slow lorises are to be translocated. © 2021, The Author(s), under exclusive licence to Japan Monkey Centre
Development of cooperation of 9th grade students in the biology topic of "How a new organism is created?
No full textSadarbības pilnveidošana 9. klases skolēniem bioloģijas tematā "Kā rodas jauns organisms?". Autors: Gustavs Loris. Darba vadītāja: Vad. pētn. Dr. paed. Rita Birziņa. Diplomdarbs, 42 lappuses, 5 attēli, 4 tabulas, 29 literatūras avoti, 9 pielikumi. Latviešu valodā. Darba mērķis ir noskaidrot, vai ar strukturētu pieeju 9. klases skolēni bioloģijas tematā "Kā rodas jauns organisms?" uzrādīs augstāku akadēmisko sniegumu un sadarbības prasmes grupu darbā. Darba metodes veido pedagoģiskais novērojums, kritērijos balstīts akadēmiskā snieguma vērtējums un aptauja. Ir secināts, ka uzdevumā ar sadarbību noteicošiem elementiem, konkrētām darba lomām skolēni uzrāda augstāku akadēmisko sniegumu un labākas sadarbības prasmes darba izstrādē, kā arī skolēniem ir augstāka skaidrība un atbildība par savu veicamo uzdevumu. Būtiskus izaicinājumus sagādā nepietiekamas sadarbībai pakārtotās prasmes, galvenokārt, komunikācijas prasmes, kuras ir attīstāmas ilgākā laika posmā.Development of cooperation of 9th grade students in the biology topic of "How a new organism is created?". Author: Gustavs Loris. Supervisor: Sen. res. Dr. paed. Rita Birziņa. Diploma thesis, 42 pages, 5 figures, 4 tables, 29 references, 9 attachments. In Latvian. Aim of this thesis is to find out, whether with structured approach 9th grade students will show higher academic achievement and cooperation skills in group work in the biology topic of "How a new organism is created?". Methods comprise pedagogic observation, academic achievement assessment based in criteria, and a survey. It is concluded that in a group task with cooperation promoting elements students show higher academic achievement and better cooperation skills during work, also the students have greater clarity and responsibility in their specific task. Significant challenges are posed by insufficient cooperation subordinate skills, as communication skills, which are to be developed in a longer period of time
Impact of Unsteady Wakes on the Secondary Flows of a High-Speed Low-Pressure Turbine Cascade
No full texteditorial reviewedThe aerodynamics of a high-speed low-pressure turbine (LPT) cascade were investigated under steady and unsteady inlet flows. The tests were performed at outlet Mach (M) and Reynolds numbers (Re) of 0.90 and 70k, respectively. Unsteady wakes were simulated by means of a wake generator equipped with bars. A bar reduced frequency (f+) of ∼0.95 was used for the unsteady case. The inlet flow field was characterized in terms of the total pressure profile and incidence. The blade aerodynamics at midspan and the secondary flow region were investigated by means of pneumatic taps and hot-film sensors. The latter provided a novel view into the impact of the secondary flows on the heat transfer topology on the blade suction side (SS). The cascade performance was quantified in terms of the outlet flow angle and losses by means of a directional multi-hole probe. The results report the phase-averaged impact of unsteady wakes on the secondary flow structures in an open test case high-speed LPT geometry
Effects of Periodic Incoming Wakes on the Aerodynamics of a High-Speed Low-Pressure Turbine Cascade
No full texteditorial reviewedThe influence of unsteady wakes incoming from the upstream stages is of high relevance in modern high-speed, low-pressure turbines (LPT) operating at transonic exit Mach numbers and low Reynolds numbers for their potential to trigger transition and influence the separation of the boundary layer on the blade suction side. The aim of this paper is the experimental characterization of the influence of incoming wakes on the 2D aerodynamics of a high-speed LPT cascade operating at a low Reynolds number and transonic exit Mach number. A detailed analysis of the status of the flow along the blade under investigation and its impact on the profile loss are presented for a range of Mach numbers from 0.70 to 0.95 and Reynolds numbers from 70k to 120k under steady and unsteady inflow conditions. Tests were conducted at on- and off-design engine realistic conditions in the VKI S-1/C wind tunnel on the SPLEEN C1 transonic cascade. The wakes incoming from an upstream blade row have been replicated using a set of rotating bars, which shed wakes at an engine-representative reduced frequency (f+=0.95) and flow coefficient (Φ=0.80). A set of densely instrumented traversable blades were used to sample the surface pressure distributions. The development of the boundary layers along the blade suction side is examined through quasi-wall shear stress obtained with surface-mounted hot-film sensors. Wake traverses were carried out downstream of the cascade with a miniaturized L-shaped five-hole probe to characterize the blade losses. The introduction of periodic incoming wakes promotes variations in the flow topology over the blade. The effect on the suction side separation bubble is shown to depend on the exit flow conditions. At low Mach numbers, the incoming wakes determine a reduction in the size of the bubble; in contrast, this effect is not registered as the exit Mach number increases. Consistently, a high dependence of the unsteady wake effect on the profile loss on the exit Reynolds and Mach numbers is demonstrated.Clean Sk
La Pedagogía de Loris Malaguzzi.: Por una "nueva" idea de infancia
No full textL’articolo illustra gli elementi essenziali che contraddistinguono il pensiero di Loris Malaguzzi inquadrando il contributo di questo Autore nell’ambito della recente storia della pedagogia dell’infanzia italiana con particolare riferimento alle realtà dell’asilo nido e della scuola dell’infanzia. In particolare, nell’articolo si delineeranno gli elementi di novità che hanno modificato in modo permanente il nostro modo d’intendere l’infanzia (e la sua educazione) soprattutto a partire dagli apporti delle teorie costruttiviste, da Piaget fino a Vygotskij, Bruner e Gardner. Da questa analisi emerge il profilo culturale di un Autore ricco e complesso, che ha saputo innovare la didattica per l’infanzia attraverso una pluralità di prospettive: da quella metodologica a quella politica, da quella della gestione degli spazi educativi fino agli orizzonti dell’educazione estetica, della creatività e della valorizzazione del gioco simbolico.
Da questa analisi ne emerge il volto di un innovatore geniale e produttivo, capace di intrecciare i linguaggi dell’educazione con quelli della cultura, del sapere tecnico con quello umanistico, senza divaricazioni, e con uno sguardo sempre attento a cogliere le potenzialità dell’infanzia, in chiave attuale e futura, immaginando così il volto di un nuovo bambino, più adeguato ad un mondo in transizione e in movimento.The article illustrates the essential elements that distinguish the thought of Loris Malaguzzi framing the contribution of this Author within the recent history of the Early Childhood Education and Care in Italy with particular reference to the pre-school sector. In particular, the contribution will outline the elements of novelty that have permanently changed the way we understand childhood (and its education), especially from the contributions of constructivist theories (Piaget Vygotskij, Bruner, Gardner). From this analysis the cultural profile of a rich and complex Author stands out, who has been able to innovate teaching for children through a plurality of perspectives: from methodological to political, from the management of educational spaces to the horizons of aesthetic education, creativity and the enhancement of symbolic play.
From this analysis emerges the face of a brilliant and productive innovator, able to intertwine the languages of education with those of culture, of technical knowledge with the humanistic one, in a unitary perspective, and with an always careful look to grasp the potential of childhood, in a current and future key, thus imagining the face of a new child, more appropriate to a world in transition and movement.El artículo ilustra los elementos esenciales que distinguen el pensamiento de Loris Malaguzzi enmarcándolo en el contexto de la historia reciente de la pedagogía infantil italiana con especial referencia al sector preescolar. En particular, la contribución describirá los elementos novedosos que han cambiado permanentemente nuestra forma de entender la infancia (y su educación), especialmente a partir de los aportes de las teorías constructivistas (Piaget Vygotskij, Bruner, Gardner). De este análisis emerge el perfil cultural de un autor rico y complejo, que ha sido capaz de innovar la enseñanza para niños a través de una pluralidad de perspectivas: de metodológica a política, desde la gestión de espacios educativos hasta los horizontes de la educación. estética, de la creatividad y de la valorización del juego simbólico.
De este análisis surge el rostro de un innovador brillante y productivo, capaz de entrelazar las lenguas de la educación con las de la cultura, del conocimiento técnico con el humanístico, en una perspectiva unitaria, y con una mirada siempre cuidadosa para captar el potencial de la infancia, en clave actual y futura, imaginando así el rostro de un nuevo niño, más apropiado para un mundo en transición y movimiento
La pedagogia di Loris Malaguzzi. : Per una ‘nuova’ idea di bambino
No full textThe article illustrates the essential elements that distinguish the thought of Loris Malaguzzi framing the contribution of this Author within the recent history of the Early Childhood Education and Care in Italy with particular reference to the pre-school sector. In particular, the contribution will outline the elements of novelty that have permanently changed the way we understand childhood (and its education), especially from the contributions of constructivist theories (Piaget Vygotskij, Bruner, Gardner). From this analysis the cultural profile of a rich and complex Author stands out, who has been able to innovate teaching for children through a plurality of perspectives: from methodological to political, from the management of educational spaces to the horizons of aesthetic education, creativity and the enhancement of symbolic play.
From this analysis emerges the face of a brilliant and productive innovator, able to intertwine the languages of education with those of culture, of technical knowledge with the humanistic one, in a unitary perspective, and with an always careful look to grasp the potential of childhood, in a current and future key, thus imagining the face of a new child, more appropriate to a world in transition and movement.El artículo ilustra los elementos esenciales que distinguen el pensamiento de Loris Malaguzzi enmarcándolo en el contexto de la historia reciente de la pedagogía infantil italiana con especial referencia al sector preescolar. En particular, la contribución describirá los elementos novedosos que han cambiado permanentemente nuestra forma de entender la infancia (y su educación), especialmente a partir de los aportes de las teorías constructivistas (Piaget Vygotskij, Bruner, Gardner). De este análisis emerge el perfil cultural de un autor rico y complejo, que ha sido capaz de innovar la enseñanza para niños a través de una pluralidad de perspectivas: de metodológica a política, desde la gestión de espacios educativos hasta los horizontes de la educación. estética, de la creatividad y de la valorización del juego simbólico.
De este análisis surge el rostro de un innovador brillante y productivo, capaz de entrelazar las lenguas de la educación con las de la cultura, del conocimiento técnico con el humanístico, en una perspectiva unitaria, y con una mirada siempre cuidadosa para captar el potencial de la infancia, en clave actual y futura, imaginando así el rostro de un nuevo niño, más apropiado para un mundo en transición y movimiento.L’articolo illustra gli elementi essenziali che contraddistinguono il pensiero di Loris Malaguzzi inquadrando il contributo di questo Autore nell’ambito della recente storia della pedagogia dell’infanzia italiana con particolare riferimento alle realtà dell’asilo nido e della scuola dell’infanzia. In particolare, nell’articolo si delineeranno gli elementi di novità che hanno modificato in modo permanente il nostro modo d’intendere l’infanzia (e la sua educazione) soprattutto a partire dagli apporti delle teorie costruttiviste, da Piaget fino a Vygotskij, Bruner e Gardner. Da questa analisi emerge il profilo culturale di un Autore ricco e complesso, che ha saputo innovare la didattica per l’infanzia attraverso una pluralità di prospettive: da quella metodologica a quella politica, da quella della gestione degli spazi educativi fino agli orizzonti dell’educazione estetica, della creatività e della valorizzazione del gioco simbolico.
Da questa analisi ne emerge il volto di un innovatore geniale e produttivo, capace di intrecciare i linguaggi dell’educazione con quelli della cultura, del sapere tecnico con quello umanistico, senza divaricazioni, e con uno sguardo sempre attento a cogliere le potenzialità dell’infanzia, in chiave attuale e futura, immaginando così il volto di un nuovo bambino, più adeguato ad un mondo in transizione e in movimento
EFFECTS OF PERIODIC INCOMING WAKES ON THE AERODYNAMICS OF A HIGH-SPEED LOW-PRESSURE TURBINE CASCADE
No full textThe influence of the unsteady wakes incoming from the upstream stages is of high relevance in modern high-speed low pressure turbines operating at transonic exit Mach numbers and low-Reynolds numbers, for their potential to trigger transition and influence the separation of the boundary layer on the blade suction side. The aim of this paper is the experimental characterization of the influence of incoming wakes on the 2D aerodynamics of a high speed LPT cascade operating at low-Reynolds and transonic exit Mach number. A detailed analysis of the status of the flow along the blade under investigation and its impact on the profile losses are presented for a range of Mach number from 0.70 to 0.95 and Reynolds number from 70,000 to 120,000 under steady and unsteady inflow conditions. Test were conducted at on- and off-design engine realistic conditions in the VKI S-1/C wind tunnel on the SPLEEN C1 transonic cascade. The wakes incoming from an upstream blade row have been replicated using a set of rotating bars, which shed wakes
at engine representative reduced frequency (=0.95) and flow coefficient (Φ=0.80). A set of densely instrumented traversable blades were used to sample the surface pressure distributions. The development
of the boundary layers along the blade suction side is examined through quasi-wall shear stress obtained with surface-mounted hot-film sensors. Wake traverses were carried out downstream of the cascade with a miniaturized L-shaped 5-hole probe to characterize the blade losses. The introduction of periodic incoming wakes promotes variations in the flow topology over the blade. The effect on the suction side separation bubble is shown to depend on the exit flow conditions. At low
Mach numbers the incoming wakes determine a reduction in the size of the bubble, in contrast this effect is not registered as the exit Mach number increases. Consistently, a high dependence of the unsteady wake effect on the profile losses on the exit Reynolds and Mach numbers is demonstrated
IMPACT OF UNSTEADY WAKES ON THE SECONDARY FLOWS OF A HIGH-SPEED LOW-PRESSURE TURBINE CASCADE
No full text<p>The aerodynamics of a high-speed low-pressure turbine (LPT) cascade was investigated under steady and unsteady flow conditions. The tests were performed at outlet Mach (M) and Reynolds numbers (Re) of 0.90 and 70k, respectively. Unsteady wakes were simulated by means of a wake generator equipped with bars. The bar reduced frequency () for the unsteady case was ~0.95. The inlet flow field was characterized in terms of the total pressure profile and incidence. The blade aerodynamics at the midspan and secondary flow region was investigated by means of pneumatic taps and hot-film sensors. The latter provided a novel view into the impact of the secondary flows on the heat-transfer topology on the blade suction side (SS). The cascade performance was quantified in terms<br>
of outlet flow angle and losses by means of a directional multi-hole probe. The results report the phase-<br>
averaged impact of unsteady wakes on the secondary flow structures in an open test case high-speed LPT geometry.</p>
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