1,720,957 research outputs found
Sclerosi Laterale Amiotrofica: SOD1 è implicata nel danno cellulare anche nei casi sporadici
No full textAmyotrophic Lateral Sclerosis: SOD1 is also involved in sporadic cases’ cellular damage
Amyotrophic Lateral Sclerosis (ALS) is a multifactorial pathology characterized by a progressive loss of motor
neurons. In 20% of cases the presentation is familiar and it is related to specific and predisposing genetic
factors. Mutations in sod1 gene have been identified in 2% of familiar cases which are likely to cause the mutated
protein to gain toxic properties for cells. The analysis of post-mortem nervous tissues of sporadic ALS
patients showed that oxidized SOD1 wild type (wt) protein has the same alterations as the mutated one. Sporadic
ALS patients’ peripheral tissues, especially lymphocytes, have been demonstrated as reliable models of
pathophysiological alterations of the disease and their use leads to remove the variability of data due to post
mortem degradation of the tissues. Our study, through peripheral lymphocytes’ analysis, demonstrates the
presence of misfolded and oxidized SOD1wt protein in sporadic ALS cases as well and examines its expression
in cellular compartments. The correlation between biological data and clinical parameters shows how
different SOD1 localizations could influence disease duration
Applicazione della tecnica perfusione MRI nella valutazione del grado di malignità dei gliomi cerebrali
No full textIn the cerebral gliomas clinical practice, correct grading is really important. Establishing the correct lesion’s malignancy
degree has relevant clinical implications, in terms of outcome and therapeutic strategies.
Histopathologicalogical evaluation of cerebral gliomas sometime is difficult because of the impossibility of surgery
or sampling mistakes, and imaging study with Magnetic Resonance provides morphological important information,
but not so reliable for malignancy. During last years, there has been a considerable development of advanced RM techniques, which completes anatomy information, providing precious indications about the functionality
of the investigated lesions. Perfusion represents the direct measure of the microvascularization of a tissue
and can be used as a marker of imaging to estimate the tumor angiogenesis and the degree of malignancy.
Our work aimed at evaluating the role of MR perfusion in establishing the correct grade of cerebral gliomas: we
analysed perfusion maps of 22 patients affected by low grade or high grade gliomas, with or without histological
confirmation, and after that we compared among tumor degrees II, III, IV and between simplified grade (low grade
gliomas and high grade gliomas) with the main parameters of perfusion CBV (Cerbral Blood Volume) e CBF (Cerebral
Blood Flow). A positive correlation has been found out between the two parameters and between the parameters
and the cancer degree and this means that the bigger the degree of malignancy, the greater the perfusion is. This
agrees with the histological datum that shows that the more consistent the vascularization, the more malignant the
lesion is. It has been possible distinguishing between high grade gliomas and low grade gliomas throw the perfusion
parameters, but it has not been possible to make a distinction between II/III and III/IV, because of the low
number of patients suffering from grade III gliomas. Therefore, perfusion MR study might represent a useful instrument
for the differential diagnosis between HGG and LGG, with relevant implications in the follow-up too. It’s
still necessary to evaluate the discriminating power of the technique in the intermediate grade tumor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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