548 research outputs found
Memoire au Parlement de la Grande Bretagne, [electronic resource] : Ou expose rapide et succinct des faits, dans l'affaire de Francois-Simon Comte de Pfaff, des barons de pfaffenhoffen, libres et immediate du saint-empire-romain, chevalier d'honneur de l'ordre souverain de malte, trefoncier de la tres-illustre eglise souveraine de liege, &c. &c. &c. contre le gouvernement britannique. Tendant a obtenir une commision militaire, composee d'Hommes d'etat probes & impartiaux, pour examiner la valeur de ses titres en reclamation, sur le departement de la guerre.
No full textSigned at end: F.S. Comte de Pfaff de Pfaffenhoffen.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
'Kristen Hovers At The Edge': First Chapter of 'I Know How To Live': The Life of Kristen Pfaff (with an afterword by Jason Pfaff).
No full textOpening chapter of biography of Kristen Pfaff by Guy Mankowski. ‘Mankowski, through painstaking research, has given a powerful voice to one of our lesser understood musical forces. A brilliant, alternative look at the 90s music scene.’ Lucy Nichol, author of The 27 Club. </p
Pfaff, D. Estrogens and brain function
No full textDonald W. Pfaff. Estrogens and brain function: neural analysis of a hormone-controlled mammalian reproductive behavior
By integrating a vast array of empirical findings, this book advances the frontier of knowledge about estrogen’s effects on nerve cells and behavior. Systematically examining the effects of estrogen on the neural circuitry underlying reproductive behavior, the author uses electrophysiological, neuroanatomical, and neuroendocrine experimental techniques to develop a complete analysis of the mechanisms for essential mammalian mating behavior.
Based on an extensive research program, Estrogens and Brain Function traces the pathways that control lordosis behavior. This book also describes the anatomical basis of hormonal accumulations in the brain and illustrates how these hormones alter neural circuits. Both the methods and the results delineated here promise to have an important impact on future investigations of brain mechanisms of mental and behavioral states.https://digitalcommons.rockefeller.edu/ru-authors/1147/thumbnail.jp
Auxiliary Linear Problem, Difference Fay Identities and Dispersionless Limit of Pfaff-Toda Hierarchy
No full textRecently the study of Fay-type identities revealed some new features of the DKP hierarchy (also known as ''the coupled KP hierarchy'' and ''the Pfaff lattice''). Those results are now extended to a Toda version of the DKP hierarchy (tentatively called ''the Pfaff-Toda hierarchy''). Firstly, an auxiliary linear problem of this hierarchy is constructed. Unlike the case of the DKP hierarchy, building blocks of the auxiliary linear problem are difference operators. A set of evolution equations for dressing operators of the wave functions are also obtained. Secondly, a system of Fay-like identities (difference Fay identities) are derived. They give a generating functional expression of auxiliary linear equations. Thirdly, these difference Fay identities have well defined dispersionless limit (dispersionless Hirota equations). As in the case of the DKP hierarchy, an elliptic curve is hidden in these dispersionless Hirota equations. This curve is a kind of spectral curve, whose defining equation is identified with the characteristic equation of a subset of all auxiliary linear equations. The other auxiliary linear equations are related to quasi-classical deformations of this elliptic spectral curve.The author is grateful to Ralf Willox and Saburo Kakei for useful information and comments. This work is partly supported by Grant-in-Aid for Scientific Research No. 19540179 and No. 21540218 from the Japan Society for the Promotion of Science
Peacekeeping and the Just War Tradition
No full textMajor Tony Pfaff, a former Assistant Professor of Philosophy at the United States Military Academy, addresses an important source of much of the confusion that currently surrounds many of the Operations Other Than War (OOTW) that the military finds itself participating in with increasing frequency. The author points out that, though the source of this confusion is primarily ethical, it has important operational implications as well. In the Just War Tradition, as well as the Law of War, there has always been a tension between winning and fighting well, and the peacekeeping environment does not change this. Commonly, the resolution of this tension is expressed in the maxim: always use the least amount of force necessary to achieve the military objective. This maxim applies, regardless of what environment one is in. The author\u27s contention is, however, that the understanding of necessary is radically different in the peacekeeping environment than it is in more conventional operations. Failure to understand this results in a great deal of confusion as soldiers try to apply an ethic designed for dealing with enemies in environments where there are none.https://press.armywarcollege.edu/monographs/1128/thumbnail.jp
Constructing and classifying fully irreducible outer automorphisms of free groups
No full textThe main theorem of this document emulates, in the context of Out(F_r) theory, a mapping class group theorem (by H. Masur and J. Smillie) that determines precisely which index lists arise from pseudo-Anosov mapping classes. Since the ideal Whitehead graph gives a finer invariant in the analogous setting of a fully irreducible outer automorphisms of free groups, we instead focus on determining which of the twenty-one connected, loop-free, five-vertex graphs are ideal Whitehead graphs of ageometric, fully irreducible outer automorphisms of free groups in rank three. Our main theorem accomplishes this by showing that there are precisely eighteen graphs arising as such. We also give a method for identifying certain complications called periodic Nielsen paths, prove the existence of conveniently decomposed representatives of ageometric, fully irreducible outer automorphisms of free groups having connected, (2r-1)-vertex ideal Whitehead graphs, and prove a criterion for identifying representatives of ageometric, fully irreducible outer automorphisms of free groups. The strategies we use for constructing fully irreducible outer automorphisms of free groups, as well as our identification and decomposition techniques, can be used to extend our main theorem, as they are valid in any rank. Our methods of proof rely primarily on Bestvina-Feighn-Handel train track theory and the theory of attracting laminations.Ph. D.Includes bibliographical referencesby Catherine Pfaf
The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
Addition Aux Observations Rapides Du Comte De Pfaff De Pfaffenhoffen, Sur La Dictature De Sa Requête A La Diète
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Jahrbuch für Kulturpolitik 2023/24: Kultur(en) der Digitalität
No full textDer Diskurs um eine Kultur der Digitalität und die damit verbundenen Transformationen bestimmen das Feld der Kultur(politik): Wie ist der Kultursektor im Bereich der Digitalität aufgestellt? Und welche Rahmenbedingungen braucht es, um kulturelle Praxis digital zu qualifizieren und Infrastrukturen zukunftsfähig zu gestalten? Die Beiträger*innen zeigen Chancen, Risiken, Herausforderungen und Handlungsoptionen für Kulturakteur*innen im digitalen Zeitalter auf. Darüber hinaus ziehen sie Rückschlüsse auf die aktuelle Verfasstheit kultureller Praxis und Infrastrukturen und stellen Möglichkeiten für deren Weiterentwicklung dar
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