34 research outputs found
The impact of surgical delay on resectability of colorectal cancer: an international prospective cohort study
No full textAim: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. Methods: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January–April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. Results: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P< 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90–1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69–1.27, P = 0.672). Longer delays were not associated with poorer outcomes. Conclusion: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease.COVIDSurg Collaborative : (Royal Adelaide Hospital, H.M Kroon ... T Sammour) ... et al
Genotypic Comparison of Pasteurella multocida from Healthy Animals at Entry to the Feedlots with That and from Bovine Respiratory Disease-Affected Animals during the Fattening Period
No full textAuthor Contributions: Conceptualization, D.C., A.I.V. and J.F.F.-G.; methodology, D.C., A.I.V. and J.F.F.-G.; software, C.S. and J.F.F.-G.; validation, D.C., A.I.V. and J.F.F.-G.; formal analysis, J.M.C.B. and C.S.; investigation, J.M.C.B. and C.S.; resources, Á.G.M., A.D.G., L.D. and D.C.; data curation, J.M.C.B., C.S., Á.G.M., A.D.G., D.C., A.I.V. and J.F.F.-G.; writing—original draft preparation, D.C. and J.F.F.-G.; writing—review and editing, J.M.C.B., C.S., Á.G.M., A.D.G., D.C., A.I.V., L.D. and J.F.F.-G.; visualization, D.C., A.I.V. and J.F.F.-G.; supervision, D.C.; project administration, D.C.; funding acquisition, D.C. and L.D. All authors have read and agreed to the published version of the manuscript.The aim of this study was to investigate the possible genotypic differences between commensal Pasteurella multocida isolates from apparently healthy animals (AHA) at the time of entry to feedlots and those from BRD-affected animals (BRD-AA). A total of 20 batches of beef calves in seven feedlots were followed-up during the fattening period. P. multocida was isolated from 28.1% of AHA and 22.9% of BRD-AA. All isolates belonged to the A: L3 genotype. Most isolates from clinical cases (81.0%) grouped into a PFGE cluster were significantly associated with BRD cases (OR, 24.9; 95% CI, 6.4–96.2). The whole genomes of 14 isolates representative of the pulsotypes most frequently detected in BRD-AA and AHA were sequenced and compared with 53 bovine genomes belonging to the identified ST13, ST79, and ST80 genotypes for a global comparison. No differences were found in the virulence-associated gene content between sequence types (STs) globally or between BRD-AA and AHA isolates in this study. Significantly, ST79 isolates harbored ARGs, conferring resistance to different antimicrobials, including macrolides and tetracyclines, which are commonly used for the treatment of BRD. Two Spanish ST79 isolates carried an ICE highly similar to ICE Tn7407, which was recently detected in Germany, suggesting that ST79 P. multocida isolates in Europe and North America may be associated with different ICEs.Universidad Complutense de MadridBanco de SantanderDepto. de Sanidad AnimalFac. de VeterinariaCentro de Vigilancia Sanitaria Veterinaria (VISAVET)TRUEpu
First Report of Lactococcus petauri in the Pumpkinseed (Lepomis gibbosus) from Candia Lake (Northwestern Italy)
No full textAuthor Contributions: Conceptualization, P.P., S.C., and M.P.; methodology, F.B., S.C., P.P., and M.P.; formal analysis, F.B., S.C., A.Z., and T.B.L.; investigation, S.C., P.P., and P.L.A.; resources, M.P.; data curation, P.P.; writing—original draft preparation, F.B., P.P., S.C., and M.P.; writing—review and editing, P.P., J.F.F.-G., and M.P.; supervision, S.C. and P.P.; project administration, M.P.; funding acquisition, M.P. All authors have read and agreed to the published version of the manuscript.Lactococcus petauri has emerged as a pathogen affecting farmed fish. In this case report, L. petauri was isolated from Lepomis gibbosus captured in Lake Candia, located in Piedmont, Northwestern Italy. Initially identified as L. garvieae using conventional methods like RAPID 32 ID STREP and MALDI-TOF, molecular analysis based on sequencing of the 16S-23S rRNA internal transcribed spacer region (ITS) confirmed it as L. petauri. The study also assessed the isolated strain’s pathogenicity by examining hemolysin and capsule cluster genes, revealing only hemolysin 2 amplicon; notably, the fish exhibited no lesions or pathological alterations. The L. petauri strain from this study displayed resistance to several antibiotics, being sensitive only to ampicillin, amoxicillin, florfenicol, and G-penicillin. This research provides new insights into host range of L. petauri and raises awareness of potential public health implications, particularly concerning zoonotic potential.
Key Contribution: L. petauri is reported for the first time in fish species in Italy; in particular, it is reported in wild pumpkinseed capture in Lake Candia located in Piedmont.Città Metropolitana di Torino (Italia)Depto. de Sanidad AnimalFac. de VeterinariaTRUEpu
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
No full textSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
No full textDelaying surgery for patients with a previous SARS-CoV-2 infection
No full textLetter to the EditorJames C Glasbey ... Brooke-Smith M ... Dudi-Venkata ...Kroon HM, Sammour T ... (COVIDSurg Collaborative
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
No full textBackground Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restrictions. Methods This international, prospective, cohort study enrolled 20 006 adult (>= 18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10middot0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16-30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0middot6% non-operation rate (26 of 4521), moderate lockdowns with a 5middot5% rate (201 of 3646; adjusted hazard ratio [HR] 0middot81, 95% CI 0middot77-0middot84; p<0middot0001), and full lockdowns with a 15middot0% rate (1775 of 11 827; HR 0middot51, 0middot50-0middot53; p<0middot0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0middot84, 95% CI 0middot80-0middot88; p<0middot001), and full lockdowns (0middot57, 0middot54-0middot60; p<0middot001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9middot1%] of 4521 in light restrictions, 317 [10middot4%] of 3646 in moderate lockdowns, 2001 [23middot8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies to protect elective staff and services.Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. Copyright (c) 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license
Modelagem da dinâmica populacional e social de Sotalia guianensis (Cetacea: Delphinidae)
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Ecologia, Florianópolis, 2011Sistemas complexos têm fascinado cientistas com sua auto-organização e propriedades emergentes. Este é um estudo em longo prazo de dois aspectos de um sistema biológico auto-organizado: a dinâmica populacional e social de Sotalia guianensis, um delfinídeo endêmico do oeste do Atlântico. A população de boto-cinza do Banco dos Abrolhos, costa leste do Brasil, oferece-se como uma boa oportunidade para modelagem de tais dinâmicas, através do tempo e espaço. Isso porque (1) o monitoramento sistemático estende-se por mais de oito anos (2002-2009), tornando evidentes mudanças demográficas de uma população aberta; e (2) porque a área de estudo abrange um hábitat altamente heterogêneo, em um gradiente de águas estuarinas internas a recifes de coral distantes da costa, o que torna a estratificação do uso do hábitat uma hipótese plausível. Em suma, este estudo tem um objetivo duplo: abordar como a população muda ao longo do tempo, fornecendo uma série de estimativas de parâmetros demográficos; e como estas mudanças afetam a estrutura social, do nível individual aos padrões da rede de interações da população. Primeiramente, o experimento de longo-prazo de marcação-recaptura (Cormack-Jolly-Seber e Desenho Robusto de Pollock) revelou uma população pequena, composta por indivíduos residentes e que temporariamente deixam ou passam pela área de estudo. Taxas de sobrevivência foram altas e constantes, o que é esperado para animais cuja expectativa de vida é muito maior que a duração do estudo. Estimativas de abundância flutuaram, possivelmente devido ao balanço entrada-saída de indivíduos, mas nenhuma tendência foi detectada. O esforço de amostragem atual apresentou alta probabilidade de detecção de declínios abruptos, uma situação mais confortável que a muitas outras populações de cetáceos. Embora ainda não sensível a variações sutis, o monitoramento poderá identificá-las com esforço adicional plausível (mais três anos). Estas mudanças populacionais encontraram-se refletidas no padrão de interações sociais. A partir da sugestão de um modelo conceitual de topologia de redes sociais de delfinídeos, uma abordagem espaço-temporal testou a estrutura da rede social de S. guianensis. Esta foi organizada em subconjuntos de indivíduos densamente conectados. O uso do espaço não pode ser atribuído à emergência destes três módulos. Por outro lado, o turnover de indivíduos na população foi o fator determinante da separação temporal das interações sociais em módulos. Dentro da escala temporal do turnover, a população seguiu uma dinâmica de fissão-fusão, caracterizada pela maioria das interações casuais e poucas associações preferidas. Os principais produtos do trabalho são como seguem: (1) Foi atestado um corpo analítico robusto, baseado em modelos de população aberta e fechada, para estimativa de diversos parâmetros demográficos baseado em dados de foto-identificação; (2) Fica salientado que fatores não-sociais podem afetar consideravelmente redes sociais não-humanas, portanto, devem ser levadas em consideração para um retrato fidedigno de sociedades com dinâmica de fissão-fusão. Tais resultados se baseam no tempo como maior fator de causa de mudança e auto-organização deste sistema complexo. Os mesmos podem inspirar pesquisa adicional, que terá implicações tanto aplicadas quanto teóricas. No primeiro caso, as análises demográficas podem ser aplicadas às demais populações de S. guianensis, para permitir comparação padronizada futura. Tal esforço conjunto permitirá uma definição adequada do status da espécie e, portanto, aperfeiçoamento dos esforços de conservação. Por fim, o modelo conceitual de redes sociais pode gerar novas hipóteses testáveis. Reconhecer os determinantes da topologia das redes sociais é um importante passo na identificação dos mecanismos atuando nos sistemas sociais. Este esforço contribui, em última instância, para abordar como características ambientais e biológicas têm interagido, moldando as diversas estruturas e dinâmicas sociais encontradas em Delphinidae.Complex systems have fascinated researchers for their self-organization and emergent properties. Here, we present a long-term study of two aspects of a biological self-organizing system: the population and social dynamics of Sotalia guianensis, an endemic delphinid of western Atlantic. The population of Guiana dolphins in the Abrolhos Bank, eastern Brazil, offers a fine opportunity for modeling such dynamics through the time and space. This is because (1) the systematic monitoring spanned for eight years (2002-2009) making demographic changes of an open population evident; and (2) the studied area encompassed a highly heterogenic habitat, in a gradient from protected inner river to offshore coral reefs, which makes a stratification of the habitat use a plausible hypothesis. In summary, this study has a twofold aim: to address how the population changes, providing a set of demographic parameter estimates, and how such changes affect the social structure, from pairwise association level to the whole population network patterns. Firstly, the long-term mark-recapture experiment (Cormack-Jolly-Seber and Pollock's Robust Design) revealed a small population, comprised of resident dolphins and individuals that temporarily leave or pass through the study area. Survival rates were high and constant, expected for animals whose life spans extend the study duration. Abundance estimates fluctuated, possibly due to balance of additions and deletions, but were no trend was detected. The current monitoring effort had high probability of detect abrupt population declines, which is a better situation than that for many other monitored cetacean stocks. Although not sensitive yet to subtle declines, the monitoring would identify such trends with feasible additional effort (additional three years). These population changes were found reflected in the patterns of social interaction. A conceptual framework for social network topology of delphinids was suggested, and had predictions tested by combining spatial, temporal and demographic approaches. The social network of Guiana dolphins was structured into a modular architecture as predicted, and the individuals' space use overlap could not be assigned as a major force driven such topology. However, the turnover of individuals in the population has temporally split the associations into the three network modules. Within the turnover temporal scale, the population followed a fission-fusion dynamics, as characterized by most fluid acquaintances and few preferred associations. Therefore, the principal outcomes of this study are as follows: (1) a robust baseline, based on open and closed population modeling, for estimating several demographic parameters was further attested to photo identification data; (2) It was highlighted that non-social factors can greatly affect non-human association networks, and should be accounted for an apposite portrayal of societies with different degrees of fission-fusion dynamics. Such results pointed the time as one of the major factors affecting the self-organization of our studied complex system. They also might inspire further research, which has both applied and theoretical implications. On the former, the suggested demographic analytical guideline may be applied to other S. guianensis populations to allow further comparisons. Such synergistic efforts will allow a reliable definition of conservation status of this species, and optimize conservation efforts. Finally, the theoretical framework of social networks may encourage new working hypothesis. Recognizing determinants of network topology is an important step towards the identification of mechanisms driving social systems. This effort, ultimately, contributes to address how environmental and biological characteristics have interacted and shaped the diversified social structure and dynamics of Delphinidae
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
No full textAim The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. Methods This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. Results Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. Conclusion One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study
No full text4826sinonenoneAkowuah E., Benson R.A., Caruana E.J., Chetty G., Edwards J., Forlani S., Gradinariu G., Murphy G.J., Oo A.Y., Patel A.J., Ridley B., Rogers L.J., Sanders J., Tyson N., Vaja R., Siaw-Acheampong K., Argus L., Chaudhry D., Dawson B.E., Glasbey J.C., Gujjuri R.R., Jones C.S., Kamarajah S.K., Khatri C., Keatley J.M., Lawday S., Li E., Mann H., Marson E.J., Mclean K.A., Picciochi M., Taylor E.H., Tiwari A., Simoes J.F., Trout I.M., Venn M.L., Wilkin R.J., Bhangu A., Nepogodiev D., Dajti I., Gjata A., Boccalatte L., Modolo M.M., Cox D., Pockney P., Townend P., Aigner F., Kronberger I., Hossain K., VanRamshorst G., Lawani I., Ataide G., Baiocchi G., Buarque I., Gohar M., Slavchev M., Agarwal A., Brar A., Martin J., Olivos M., Calvache J., Perez Rivera C.J., Hadzibegovic A.D., Kopjar T., Mihanovic J., Klat J., Novysedlak R., Christensen P., El-Hussuna A., Batista S., Lincango E., Emile S.H., Mengesha M.G., Hailu D.S., Tamiru H., Kauppila J., Laukkarinen J., Arnaud A., Albertsmeiers M., Lederhuber H., Loffler M., Tabiri S., Metallidis S., Tsoulfas G., Lorena M.A., Grecinos G., Mersich T., Wettstein D., Ghosh D., Kembuan G., Brouk P., Khosravi M., Mozafari M., Adil A., Mohan H.M., Zmora O., Fiore M., Gallo G., Pata F., Pellino G., Satoi S., Ayasra F., Chaar M., Fakhradiyev I.R., Jamal M., Elhadi M., Gulla A., Roslani A., Martinez L., Ramos De La Medina A., Outani O., Jonker P., Kruijff S., Noltes M., Steinkamp P., van der Plas W., Ademuyiwa A., Osinaike B., Seyi-olajide J., Williams E., Pejkova S., Augestad K.M., Soreide K., Al Balushi Z., Qureshi A., Sayyed R., Mohsen Daraghmeh M.A., Abukhalaf S., Cukier M., Gomez H., Shu S., Vasquez X., Parreno-Sacdalan M.D., Major P., Azevedo J., Cunha M., Santos I., Zarour A., Bonci E.-A., Negoi I., Efetov S., Litvin A., Ntirenganya F., AlAmeer E., Radenkovic D., Hong Xiang F.K., Hoe C.M., Chi Yong J.N., Moore R., Nhlabathi N., Colino R.B., Bravo A.M., Minaya-Bravo A., Jayarajah U., Wickramasinghe D., Elmujtaba M., Jebril W., Rutegard M., Sund M., Isik A., Leventoglu S., Abbott T.E., Benson R., Caruna E., Chakrabortee S., Demetriades A., Desai A., Drake T.D., Edwards J.G., Evans J.P., Ford S., Fotopoulou C., Griffiths E., Hutchinson P., Jenkinson M.D., Khan T., Knight S., Kolias A., Leung E., McKay S., Norman L., Ots R., Raghavan V., Roberts K., Schache A., Shaw R., Shaw K., Smart N., Stewart G., Sundar S., Vimalchandran D., Wright N., Alshryda S., Alser O., Breen K., Ganly I., Kaafarani H., Kendall B., Mashbari H., Al Naggar H., Mazingi D., Simoes J.F.F., Dajti I., Valenzuela J.I., Boccalatte L.A., Gemelli N.A., Smith D.E., Dudi-Venkata N.N., Kroon H.M., Sammour T., Roberts M., Mitchell D., Lah K., Pearce A., Morton A., Dawson A.C., Drane A., Sharpin C., Nataraja R.M., Pacilli M., Cox D.R.A., Muralidharan V., Riddiough G.E., Clarke E.M., Jamel W., Qin K.R., Pockney P., Cope D., Egoroff N., Lott N., Putnis S., De Robles S., Ang Z., Mitteregger M., Uranitsch S., Stiegler M., Seitinger G., Aigner F., Lumenta D.B., Nischwitz S.P., Richtig E., Pau M., Srekl-Filzmaier P., Eibinger N., Michelitsch B., Fediuk M., Papinutti A., Seidel G., Kahn J., Cohnert T.U., Messner F., Ofner D., Presl J., Varga M., Weitzendorfer M., Emmanuel K., Binder A.D., Zimmermann M., Holawe S., Nkenke E., Grimm C., Kranawetter M., Rahman Mitul A., Islam N., Karim S., Komen N., Ang E., De Praetere H., Tollens T., Schols G., Smets C., Haenen L., Quintens J., Van Belle K., Van Ramshorst G.H., Pattyn P., Desender L., Martens T., Van de putte D., Lerut P., Grimonprez A., Janssen M., De Smul G., Wallaert P., Van den Eynde J., Oosterlinck W., Van den Eynde R., Sermon A., Boeckxstaens A., Cordonnier A., De Coster J., Jaekers J., Politis C., Miserez M., Duchateau N., De Gheldere C., Flamey N., Christiano A., Guidi B., Minussi A.L., Castro S., Okoba W., Maldonado F.H.R., Oliveira P., Baldasso T., Santos L., Gomes G.M.A., Buarque I.L., Pol-Fachin L., Bezerra T.S., Barros A.V., da Silva A.M.R., Leite A.L.S., Silvestre D.W.A., Ferro C.C., Araujo M.S., Lopes L.M., Damasceno P.D., Araujo D.H.S., Laporte G., Salem M.C., Guimaraes-Filho M.A.C., Nacif L., Flumignan R.L.G., Nakano L.C.U., Kuramoto D.A.B., Aidar A.L.S., Pereda M.R., Correia R.M., Santos B.C., Carvalho A.A., Amorim J.E., Guedes Neto H.J., Areias L.L., Sousa A.F., Flumignan C.D.Q., Lustre W.G., Moreno D.H., Barros N., Baptista-Silva J.C.C., Matos L.L., Kowaski L.P., Kulcsar M.A.V., Nunes K.S., Teixeira M.F., Nunes R.L., Ijichi T.R., Kim N.J., Marreiro A., Muller B., Barakat Awada J., Baiocchi G., Kowalski L.P., Vartanian J.G., Makdissi F.B., Aguiar S., Marques N., Carvalho G.B., Marques T.M.D.M., Abdallah E.A., Zurstrassen C.E., Gross J.L., Zequi S.C., Goncalves B.T., Santos S.S., Duprat J.P., Coimbra F.J.F., Cicco R., Takeda F., Cecconello I., Ribeiro U., Gatti A., Oliva R., Nardi C., Slavchev M., Atanasov B., Belev N., Dell A., Bigam D., Dajani K., Al Riyami S., Martin J., Cheng D., Yang H., Fayad A., Carrier F.M., Amzallag E., Desroches J., Ruel M., Caminsky N.G., Boutros M., Moon J., Wong E.G., Vanounou T., Pelletier J., Wong S., Girsowicz E., Bayne J., Obrand D., Gill H., Steinmetz O., MacKenzie K., Lukaszewski M., Jamjoum G., Richebe P., Verdonck O., Discepola S., Godin N., Idrissi M., Briatico D., Sharma S., Talwar G., Bailey K., Lecluyse V., Cote G., Demyttenaere S., Garfinkle R., Kouyoumdjian A., Dumitra S., Khwaja K., Luo L., Berry G., Liberman A.S., Schmid S., Spicer J., Al Farsi M., Abou-Khalil J., Couture E., Mohammadi S., Tremblay H., Gagne N., Bergeron A., Turgeon A., Costerousse O., Bellemare D., Babin C., Blier C., Wood M.L., Persad A., Groot G., Pham H., D'Aragon F., Carbonneau E., Bouchard M., Masse M., Pesant F., Heroux J., Karanicolas P., Hallet J., Nadler A., Nathens A., Ko M., Brar A., Mayson K., Kidane B., Srinathan S., Escudero M.I., Reyes J.T., Modolo M.M., Ramirez Nieto P., Sepulveda R., Bolbaran A., Molero A., Ruiz I., Reyes G.P., Salas R., Suazo C., Munoz R., Grasset E., Inzunza M., Besser N., Irarrazaval M.J., Jarry C., Bellolio F., Romero Manqui C.A., Ruiz Esquide M., Fuentes T., Campos J., Perez Rivera C.J., Cabrera P.A., Pinilla R.E., Guevara O., Jimenez Ramirez L.J., Velasquez Cuasquen B.G., Herrera Mora D.R., Bonilla A., Diaz S., Manrique E., Facundo H., Velez Bernal J.L., Angel J., Garcia M., Guzman L., Lehmann C., Cervera S., Trujillo Sanchez L.M., Guevara R., Valbuena D., Suarez L., Jimenez G., Velandia A., Vargas J., Espinosa J., Rey S., Mendoza Quevedo J., Calvache J.A., Orozco-Chamorro C.M., Sanchez-Gomez T.A., Rojas-Tejada D.A., Mihanovic J., Bakmaz B., Rakvin I., Sulen N., Andabaka T., Luksic I., Mamic M., Martinek L., Skrovina M., Zatecky J., Peteja M., Kristensen H.O., Mekhael M., Christensen P., Westh L., Smith H., Haugstvedt A.F., Jonsson M.L., Crespo A., Batista S., Rodriguez-Abreu J., Tactuk N., Diaz-Delgado P.J., Rivas R., Sarmiento-Bobadilla J.A., Ashoush F., Samir Abdelaal A., Qatora M.S., Elsayed Hewalla M.E., Metwalli M., Atta R., 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