38,793 research outputs found
[Telegram from E. F. Simms to Odelia R. Staiti - October 3, 1933]
No full textTelegram from E. F. Simms to Odelia R. Staiti, offering sympathy regarding the recent passing of her husband, Henry T. Staiti
Final isotope heater locations and masking pattern -- Passive Seismic Experiment Package Central Station
No full textThe parametric studies have been completed. Since the thermal characteristics of the three configurations were so similar, the selection was primarily based upon mechanical considerations. A unique rectangular masking pattern has been found which, within the assumptions discussed, satisfy the specified thermal plate average temperature limits, of -65 F to +140 F.prepared by R. J. Simms
Deed from F. R. and Sue Simms to Henry R. Partridge, Coosa County, Alabama, June 5, 1868
No full textAn item from the papers of Barrie Lucien Holt. These papers cover Holt's life as a capitalist, planter, financier and Quartermaster General of the Alabama National Guard. Holt was an organizer and majority shareholder in the Prattville Cotton Mills and Banking Company, as well as a partner in D.M. Snow and Company which owned a hardware store and engaged in money-lending
Letter from Carl Hayden to F. R. Goodman, County Engineer
No full textLetter from Carl Hayden to F. R. Goodman regarding the construction of new roads
Letter from Carl Hayden to F. R. Goodman
No full textLetter from Carl T. Hayden to F. R. Goodman concerning the purchase of Bright Angel Trail and construction of an approach road to the park
Letter from F. R. Goodman to Carl Hayden
No full textLetter from F. R. Goodman to Carl T. Hayden asking for clarification about the agreement to construct an approach road to the par
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
F. R. Leavis: The Creative University
No full textThis is a critical introduction to the educational thought of F. R. Leavis (1895-1978), the greatest English literary critic of the twentieth century, providing the first in-depth examination of Leavis's ideas in relation to contemporary mass higher education. During the course of a long, prolific and controversial academic career, which saw him take issue with figures such as Wittgenstein, T. S. Eliot and C. P. Snow, Leavis became one of the most articulate advocates for the idea of the university as 'a centre of consciousness and human responsibility' in the face of what he saw as the relentless technological drive of civilisation. With the journal Scrutiny which he co-founded, as well as his critical writings, Leavis became a decisive influence on generations of teachers in Britain and overseas. Widely misrepresented as narrowly elitist, his ideas about 'the creative university', with their radical, student-centred approach to teaching, constitute a powerful resource for a higher education system grappling with the contradictory demands of continuity and change. Based on original research, the study provides an overview of Leavis's life, work and heritage and his educational world view, and a comprehensive exploration of Leavis's pedagogy from theoretical and practical perspectives. It also includes a first-hand account by the author of being taught by Leavis in person
The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances
No full textSerotonin receptor (5-HTR) agonists that target 5-HT(4(a))R and 5-HT(1A)R can reverse mu-opioid receptor (mu-OR)-evoked respiratory depression. Here, we have tested whether such rescuing by serotonin agonists also applies to the cardiovascular system. In working heart-brainstem preparations in situ, we have recorded phrenic nerve activity, thoracic sympathetic chain activity (SCA), vascular resistance and heart rate (HR) and in conscious rats, diaphragmatic electromyogram, arterial blood pressure (BP) and HR via radio-telemetry. In addition, the distribution of 5-HT(4(a))R and 5-HT(1A)R in ponto-medullary cardiorespiratory networks was identified using histochemistry. Systemic administration of the mu-OR agonist fentanyl in situ decreased HR, vascular resistance, SCA and phrenic nerve activity. Subsequent application of the 5-HT(1A)R agonist 8-OH-DPAT further enhanced bradycardia, but partially compensated the decrease in vascular resistance, sympathetic activity and restored breathing. By contrast, the 5-HT(4(a))R agonist RS67333 further decreased vascular resistance, HR and sympathetic activity, but partially rescued breathing. In conscious rats, administration of remifentanyl caused severe respiratory depression, a decrease in mean BP accompanied by pronounced bradyarrhythmia. 8-OH-DPAT restored breathing and prevented the bradyarrhythmia; however, BP and HR remained below baseline. In contrast, RS67333 further suppressed cardiovascular functions in vivo and only partially recovered breathing in some cases. The better recovery of mu-OR cardiorespiratory disturbance by 5-HT(1A)R than 5-HT(4(a))R is supported by the finding that 5-HT(1A)R was more densely expressed in key brainstem nuclei for cardiorespiratory control compared with 5-HT(4(a))R. We conclude that during treatment of severe pain, 5-HT(1A)R agonists may provide a useful tool to counteract opioid-mediated cardiorespiratory disturbances.British Heart Foundation [RG/07/006/23634]; Wellcome Trust [074570
Recommended from our members
Memories of Robert F. Heizer (1915ñ1979)
No full textThe Pioneers section of the Journal features personal reflections on major figures in the study of the indigenous
cultures of the region. Neither obituary nor memorial, Pioneers shares candid recollections that convey insight into the
personalities and the cultural context of anthropology that shaped the scholarship of these pioneers.
Pioneers began with the 2015 issue, and in these first few years the focus has tilted toward the Great Basin rather
than interior and coastal California. This decision was based on the existence of a similar effort, ìSands of Time,î in
the journal California Archaeology that does an admirable job of remembering some of the early scholars of California
anthropology. Perhaps it is time to broaden our geographic range for the JCGBA Pioneers section, and to also remind
readers that the subject matter is anthropology, not just archaeology. The Pioneers sections in the 2016 issues of the
Journal featuring Isabel Kelly and Julian Steward remind us of the intellectual breadth of these pioneers. If you have
suggestions regarding a potential Pioneer, and the names and contact information for those who may wish to share a
recollection, please contact Steven Simms ([email protected])
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